Interracial study of pathogenesis in type 1 diabetes by using a novel autoantigen INS-IGF2.

Research Project

Project/Area Number	16K09769
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Metabolomics
Research Institution	Osaka Medical College
Principal Investigator	Kanatsuna Norio 大阪医科大学, 医学部, 助教 (80738360)
Project Period (FY)	2016-04-01 – 2020-03-31
Project Status	Completed (Fiscal Year 2019)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	1型糖尿病 / INS-IGF2 / 膵島関連自己抗体 / HLA / 糖尿病 / 免疫学 / 内科
Outline of Final Research Achievements	The aim of this study was to determine INS-IGF2 autoantibodies in Japanese type 1 diabetes patients and controls, and compare with Swedish type 1 diabetes patients to clarify that INS-IGF2 autoimmunity contributes to type 1 diabetes. As a result, the levels of INS-IGF2 autoantibodies in Japanese type 1 diabetes patients were lower than in Japanese controls, although in Swedish type 1 diabetes patients were higher than in Swedish controls in previous reports.
Academic Significance and Societal Importance of the Research Achievements	日本人とスウェーデン人では1型糖尿病の発症メカニズムの一部が異なっている可能性を示す大変興味深い結果であり、今後、INS-IGF2に関するさらなる究明が必要と考えられた。今回の測定結果については、小集団に分類する、他の膵島関連自己抗体と抗INS-IGF2自己抗体との関係について調べる等、別の解析を追加することで、より詳細な検討を行う予定である。