Investigation of ghrelin effects on gut hormones and glucose metabolism using transgenic mice
| Project/Area Number |
16K09807
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
有安 宏之 和歌山県立医科大学, 医学部, 講師 (50378650)
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| Research Collaborator |
Iwakura Hiroshi
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | グレリン / トランスジェニックマウス / 糖代謝 / 消化管ホルモン / 糖尿病 / 遺伝子改変動物 / 応用動物 |
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| Outline of Final Research Achievements |
Subcutaneous injection of ghrelin resulted in no significant changes in plasma GLP1 levels in wild type mice. Addition of ghrelin or desacyl ghrelin on primary cultured epithelial cells of mouse small intestine showed no significant effects on GIP, preproglucagon, PYY, and CCK mRNA levels. There were no significant changes in plasma GIP and GLP-1 levels and intestinal GIP, preproglucagon, PYY, and CCK mRNA levels in SAP-ghrelin transgenic mice. In conclusion, we could not find any evidence that ghrelin or desacyl ghrelin has effects on the expression or secretion of gastrointestinal hormones.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の検討により、グレリンあるいはデスアシルグレリンのGIP、GLP-1、CCK、PYYといった消化管ホルモンに与える影響は、存在したとしても大きくないことが判明した。一方で、デスアシルグレリンの慢性過剰状態はやはり耐糖能を改善することが確認された。以上の結果は、グレリンあるいはデスアシルグレリンの臨床応用を考える際の、消化管ホルモンを介した耐糖能への影響を確認したという意味で、学術的また社会的にも意義のある結果であると考えられた。
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Reduced Expression of Mismatch Repair Genes MSH6/MSH2 Directly Promotes Pituitary Tumor Growth via the ATR-Chk1 Pathway2018
Author(s)
Uraki S, Ariyasu H, Doi A, Kawai S, Takeshima K, Morita S, Fukai J, Fujita K, Furuta H, Nishi M, Sugano K, Inoshita N, Nakao N, Yamada S, Akamizu T
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Journal Title
J Clin Endocrinol Metab
Volume: 103
Issue: 3
Pages: 1171-1179
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC2017
Author(s)
Hadjidaniel MD, Muthugounder S, Hung LT, Sheard MA, Shirinbak S, Chan RY, Nakata R, Borriello L, Malvar J, Kennedy RJ, Iwakura H, Akamizu T, Sposto R, Shimada H, DeClerck YA, Asgharzadeh S
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Journal Title
Oncotarget
Volume: 8
Issue: 53
Pages: 91516-91529
DOI
Related Report
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[Journal Article] Changes in Energy Metabolism After Continuous Positive Airway Pressure for Obstructive Sleep Apnea2016
Author(s)
Tachikawa R, Ikeda K, Minami T, Matsumoto T, Hamada S, Murase K, Tanizawa K, Inouchi M, Oga T, Akamizu T, Mishima M, Chin K
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Journal Title
Am J Respir Crit Care Med
Volume: 194
Pages: 729-738
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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