Basical study on the Ghrelin's protective effect against the Radiation Injury.
| Project/Area Number |
16K09814
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 元康 獨協医科大学, 医学部, 助教 (20418891)
細田 洋司 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (40359807)
御船 弘治 久留米大学, 医学部, 准教授 (70174117)
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| Research Collaborator |
NASU saori
KOJIMA masayasu
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | グレリン / 放射線障害 / 血球障害 / ラジオイムノアッセイ / 骨髄抑制 / 放射線宿酔 / アポトーシス / 放射線 / 生体防護 / ペプチドホルモン |
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| Outline of Final Research Achievements |
In mice, exposed to 3 Gy of X-ray irradiation, iv-administration of ghrelin significantly diminished a“decline-ratio”of WBC and RBC number in peripheral blood. This finding indicated a protective effect of ghrelin against the blood cell damage by the“myelo-suppressive dose” of whole body irradiation. Administration of ghrelin significantly and dose-dependently increased the survival-ratio of cultured human PBL irradiated by 3 Gy of X-ray. This finding indicated a direct effect of ghrelin on the PBL which have been reported to possess a classical ghrelin receptor (GHSR1a). Intravenous administration of ghrelin suppressed the PICA (kaolin-ingestion behaviour correlating emetic action) of mice indicating an anti-emetic effect against radiation sickness. Production and the secretion of ghrelin increased upon 3 Gy X-ray exposure in mice. These findings indicated that the administration of ghrelin might be one of the therapeutic candidates against the radiation-injury.
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| Academic Significance and Societal Importance of the Research Achievements |
脳腸ホルモン「グレリン」の分泌が、放射線障害を受けたマウスの体内で一過性に増加して、同ホルモンが放射線障害を抑制する可能性について報告した。グレリンには、各種の生体防御作用が既に報告されているが、今回のわれわれの報告で、放射線障害に対するグレリンを用いた治療の可能性が示された。グレリンには各種の誘導体（ghrelin-mimetrics）が作成されており、これらを用いた放射線障害への新たな治療戦略の可能性が、本研究を通じて示された。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] The Emerging Role of FOXL2 in Regulating the Transcriptional Activation Function of Estrogen Receptor β: An Insight Into Ovarian Folliculogenesis.2017
Author(s)
Hirano M, Wada-Hiraike O, Fu H, Akino N, Isono W, Sakurabashi A, Fukuda T, Morita Y, Tanikawa M, Miyamoto Y, Nishi Y, Yanase T, Harada M, Oishi H, Yano T, Koga K, Oda K, Kawana K, Fujii T, Osuga Y.
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Journal Title
Reprod Sci
Volume: 24
Issue: 1
Pages: 133-141
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Association of miR-146aC>G, miR-149C>T, miR-196a2T>C, and miR-499A>G polymorphisms with risk of recurrent implantation failure in Korean women.2016
Author(s)
Cho SH, Chung KW, Kim JO, Jang H, Yoo JK, Choi Y, Ko JJ, Kim JH, Nishi Y, Yanase T, Lee WS, Kim NK.
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Journal Title
Eur J Obstet Gynecol Reprod Biol
Volume: 202
Pages: 14-19
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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