| Project/Area Number |
16K09814
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 元康 獨協医科大学, 医学部, 助教 (20418891)
細田 洋司 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (40359807)
御船 弘治 久留米大学, 医学部, 准教授 (70174117)
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| Research Collaborator |
NASU saori
KOJIMA masayasu
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | グレリン / 放射線障害 / 血球障害 / ラジオイムノアッセイ / 骨髄抑制 / 放射線宿酔 / アポトーシス / 放射線 / 生体防護 / ペプチドホルモン |
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| Outline of Final Research Achievements |
In mice, exposed to 3 Gy of X-ray irradiation, iv-administration of ghrelin significantly diminished a“decline-ratio”of WBC and RBC number in peripheral blood. This finding indicated a protective effect of ghrelin against the blood cell damage by the“myelo-suppressive dose” of whole body irradiation. Administration of ghrelin significantly and dose-dependently increased the survival-ratio of cultured human PBL irradiated by 3 Gy of X-ray. This finding indicated a direct effect of ghrelin on the PBL which have been reported to possess a classical ghrelin receptor (GHSR1a). Intravenous administration of ghrelin suppressed the PICA (kaolin-ingestion behaviour correlating emetic action) of mice indicating an anti-emetic effect against radiation sickness. Production and the secretion of ghrelin increased upon 3 Gy X-ray exposure in mice. These findings indicated that the administration of ghrelin might be one of the therapeutic candidates against the radiation-injury.
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| Academic Significance and Societal Importance of the Research Achievements |
脳腸ホルモン「グレリン」の分泌が、放射線障害を受けたマウスの体内で一過性に増加して、同ホルモンが放射線障害を抑制する可能性について報告した。グレリンには、各種の生体防御作用が既に報告されているが、今回のわれわれの報告で、放射線障害に対するグレリンを用いた治療の可能性が示された。グレリンには各種の誘導体（ghrelin-mimetrics）が作成されており、これらを用いた放射線障害への新たな治療戦略の可能性が、本研究を通じて示された。
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