Relationship between NfkB signaling and epigeneteic signaling in malignant lymphoma.

• Project/Area Number: 16K09865
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: International University of Health and Welfare (2017-2018); National Cancer Center Japan (2016)
• Principal Investigator: Kobayashi Yukio 国際医療福祉大学, 医学部, 教授 (50240734)
• Co-Investigator(Kenkyū-buntansha): 野本 順子 国際医療福祉大学, 医学部ゲノム医学研究所, 助手 (30601322) ; 福原 傑 国立研究開発法人国立がん研究センター, 中央病院, 医員 (70445295) ; 棟方 理 国立研究開発法人国立がん研究センター, 中央病院, 医員 (80601319) ; 前島 亜希子 国立研究開発法人国立がん研究センター, 中央病院, 医員 (90342906)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: BCR / NFkB / target sequence / ALK gene / MYD88 gene / CD79B gene / びまん性大細胞Bリンパ腫 / 晩期再発 / 免疫サーベイランス / Class I抗体 / Class II抗体 / 癌 / 内科

Outline of Final Research Achievements

We performed target sequences of 18 pairs of primary and relapsed DLBCL cases. Among them, 9 pairs had common mutations in MYD88, CD79B, RHOA, TNFRSF14, PIM,MLL2, CREBBP, PRDM1, MEF2B genes.Some common characteristics might be shared in a subgroup of pts with limited-stage DLBCL who developed LR; they had non-GCB type, mutation in both or either of CD79B and MYD88 and specific extranodal diseases. Especially, at least four pts were considered to have MCD type with co-mutation of CD79B and MYD88.
The mechanisms of localized relapse(LR) were considered heterogeneous. In addition to the well-known mechanism of relapse with indolent BCL components, acquiring functions associated with immune evasion were speculated in limited pts. Immunodeficiency by aging might also be associated with LR because median age at LR was 71 years, relatively old. Other mechanisms of LR, such as gene alteration involving other than PD-L1 must exist although not revealed in our study.

Academic Significance and Societal Importance of the Research Achievements

悪性リンパ腫の検体で実用上、問題なく遺伝子検査ができる系を確立した。悪性リンパ腫では、個々の遺伝子変異に応じた治療薬が１：１で見つかるわけではない。しかし、悪性リンパ腫の発症に関する遺伝子群（パスウェイ）がわかってきており、そのパスウェイごとには、阻害剤が発見されてきている。
この研究は、将来的には、個別化治療の元になり、より副作用がない、より効果のある治療薬が選択できる元となると考えられる。事実、限局性の病変で、長年の後に再発している例では、将来はそのパスウェイに応じた治療薬で維持療法を行うようになるかもしれない。

Research Products

• [Journal Article] Early disease progression in patients with localized NK/T-cell lymphoma treated with concurrent chemoradiotherapy. (2018)
  • Author(s): Yamaguchi M, Suzuki R, Kim SJ, Ko YH, Oguchi M, Asano N, Miyazaki K, Terui Y, Kubota N, Maeda T, Kobayashi Y, Amaki J, Soejima T, Saito B, Shimoda E, Fukuhara N, Tsukamoto N, Shimada K, Choi I, Utsumi T, Ejima Y, Kim WS, Katayama N.
  • Journal Title: Cancer Sci Volume: - Issue: 6 Pages: 2056-2062
  • DOI: 10.1111/cas.13597
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gene Expression Profile Signature of Aggressive Waldenstrom Macroglobulinemia with Chromosome 6q Deletion (2018)
  • Author(s): Sekiguchi, N. Nomoto, J. Nagata, A. Kiyota, M. Fukuda, I. Yamada, K. Takezako, N. Kobayashi, Y.
  • Journal Title: Biomed Res Int Volume: 2018 Pages: 6728128-6728128
  • DOI: 10.1155/2018/6728128
  • Peer Reviewed / Open Access
• [Journal Article] Double-Expressor Lymphoma Is Associated with Poor Outcomes after Allogeneic Hematopoietic Cell Transplantation (2018)
  • Author(s): Kawashima, I. Inamoto, Y. Maeshima, A. M. Nomoto, J. Tajima, K. Honda, T. Shichijo, T. Kawajiri, A. Takemura, T. Onishi, A. Ito, A. Tanaka, T. Fuji, S. Kurosawa, S. Kim, S. W. Maruyama, D. Tobinai, K. Kobayashi, Y. Fukuda, T.
  • Journal Title: Biol Blood Marrow Transplant Volume: 24 Issue: 2 Pages: 294-399
  • DOI: 10.1016/j.bbmt.2017.10.013
  • Peer Reviewed / Open Access
• [Journal Article] Partial deletion of the ALK gene in ALK-positive anaplastic large cell lymphoma (2018)
  • Author(s): Fukuhara Suguru、Nomoto Junko、Kim Sung-Won、Taniguchi Hirokazu、Miyagi Maeshima Akiko、Tobinai Kensei、Kobayashi Yukio
  • Journal Title: Hematological Oncology Volume: 36 Issue: 1 Pages: 150-158
  • DOI: 10.1002/hon.2455
  • Peer Reviewed / Open Access
• [Journal Article] Phase I study of panobinostat and 5-azacitidine in Japanese patients with myelodysplastic syndrome or chronic myelomonocytic leukemia (2018)
  • Author(s): Kobayashi, Y. Munakata, W. Ogura, M. Uchida, T. Taniwaki, M. Kobayashi, T. Shimada, F. Yonemura, M. Matsuoka, F. Tajima, T. Yakushijin, K. Minami, H.
  • Journal Title: Int J Hematol Volume: 107 Issue: 1 Pages: 83-91
  • DOI: 10.1007/s12185-017-2327-9
  • Peer Reviewed / Open Access
• [Journal Article] Expression pattern of PD-L1 and PD-L2 in classical Hodgkin lymphoma, primary mediastinal large B-cell lymphoma, and gray zone lymphoma (2018)
  • Author(s): Tanaka Yosuke、Maeshima Akiko Miyagi、Nomoto Junko、Makita Shinichi、Fukuhara Suguru、Munakata Wataru、Maruyama Dai、Tobinai Kensei、Kobayashi Yukio
  • Journal Title: European Journal of Haematology Volume: 100 Issue: 5 Pages: 511-517
  • DOI: 10.1111/ejh.13033
  • Peer Reviewed / Open Access
• [Journal Article] Follow-up of a randomised phase II study of chemotherapy alone or in combination with mogamulizumab in newly diagnosed aggressive adult T-cell leukaemia-lymphoma: impact on allogeneic haematopoietic stem cell transplantation (2018)
  • Author(s): Ishida T、Jo T、Takemoto S、Suzushima H、Suehiro Y、Choi I、Yoshimitsu M、Saburi Y、Nosaka K、Utsunomiya A、Kobayashi Y、Yamamoto K、Fujiwara H、Ishitsuka K、Yoshida S、Taira N、Imada K、Kato K、Moriuchi Y、Yoshimura K、Takahashi T、Tobinai K、Ueda R
  • Journal Title: British Journal of Haematology Volume: 印刷中 Issue: 3 Pages: 479-483
  • DOI: 10.1111/bjh.15123
  • Peer Reviewed / Open Access
• [Journal Article] Deeper molecular response is a predictive factor for treatment-free remission after imatinib discontinuation in patients with chronic phase chronic myeloid leukemia: the JALSG-STIM213 study (2017)
  • Author(s): Takahashi Naoto、Miyata Yasuhiko、Kobayashi Shinichi、Usuki Kensuke、Matsumura Itaru、Minami Yosuke、Usui Noriko、Fukuda Tetsuya、Kobayashi Yukio、Kiyoi Hitoshi、et al.
  • Journal Title: Int J Hematol Volume: 107 Issue: 2 Pages: 185-193
  • DOI: 10.1007/s12185-017-2334-x
  • Peer Reviewed / Open Access
• [Journal Article] High-dose methotrexate therapy significantly improved survival of adult acute lymphoblastic leukemia: a phase III study by JALSG (2017)
  • Author(s): Sakura T、Hayakawa F、Sugiura I、Murayama T、Imai K、Usui N、Fujisawa S、Yamauchi T、Yujiri T、Kakihana K、Ito Y、Kanamori H、Ueda Y、Miyata Y、Kurokawa M、Asou N、Ohnishi K、Ohtake S、Kobayashi Y、Matsuo K、Kiyoi H、Miyazaki Y、Naoe T
  • Journal Title: Leukemia Volume: 32 Issue: 3 Pages: 626-632
  • DOI: 10.1038/leu.2017.283
  • Peer Reviewed / Open Access
• [Journal Article] Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia. (2017)
  • Author(s): Togasaki E, Takeda J, Yoshida K, Shiozawa Y, Takeuchi M, Kiyoi H, Ohnishi K, Ohtake S, Asou N, Kobayashi Y, Miyazaki Y, Miyano S, Ogawa S, Matsumura I, Nakaseko C, Naoe T.
  • Journal Title: Blood Cancer J. Volume: 7 Issue: 4 Pages: 2017-2017
  • DOI: 10.1038/bcj.2017.36
  • Peer Reviewed / Open Access
• [Journal Article] Azacitidine-induced acute lung injury in a patient with therapy-related myelodysplastic syndrome (2017)
  • Author(s): Makita Shinichi、Munakata Wataru、Watabe Daisuke、Maeshima Akiko Miyagi、Taniguchi Hirokazu、Toyoda Kosuke、Yamauchi Nobuhiko、Fukuhara Suguru、Maruyama Dai、Kobayashi Yukio、Tobinai Kensei
  • Journal Title: Journal of International Medical Research Volume: 45 Issue: 2 Pages: 886-893
  • DOI: 10.1177/0300060517698331
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of clinicopathologic characteristics of gastric follicular lymphomas and duodenal follicular lymphomas (2017)
  • Author(s): Maeshima Akiko Miyagi、Taniguchi Hirokazu、Suzuki Tomotaka、Yuda Sayako、Toyoda Kosuke、Yamauchi Nobuhiko、Makita Shinichi、Fukuhara Suguru、Munakata Wataru、Maruyama Dai、Kobayashi Yukio、Saito Yutaka、Tobinai Kensei
  • Journal Title: Human Pathology Volume: 65 Pages: 201-208
  • DOI: 10.1016/j.humpath.2017.04.025
  • Peer Reviewed
• [Journal Article] Mogamulizumab for relapsed adult T-cell leukemia-lymphoma: Updated follow-up analysis of phase I and II studies (2017)
  • Author(s): Ishida Takashi、Utsunomiya Atae、Jo Tatsuro、Yamamoto Kazuhito、Kato Koji、Yoshida Shinichiro、Takemoto Shigeki、Suzushima Hitoshi、Kobayashi Yukio、Imaizumi Yoshitaka、Yoshimura Kenichi、Kawamura Kouichi、Takahashi Takeshi、Tobinai Kensei、Ueda Ryuzo
  • Journal Title: Cancer Science Volume: 108 Issue: 10 Pages: 2022-2029
  • DOI: 10.1111/cas.13343
  • Peer Reviewed / Open Access
• [Journal Article] Distribution of malignant lymphomas in the anterior mediastinum: a single-institution study of 76 cases in Japan, 1997?2016 (2017)
  • Author(s): Maeshima Akiko Miyagi、Taniguchi Hirokazu、Suzuki Tomotaka、Yuda Sayako、Toyoda Kosuke、Yamauchi Nobuhiko、Makita Shinichi、Fukuhara Suguru、Munakata Wataru、Maruyama Dai、Kobayashi Yukio、Tobinai Kensei
  • Journal Title: International Journal of Hematology Volume: 106 Issue: 5 Pages: 675-680
  • DOI: 10.1007/s12185-017-2331-0
  • Peer Reviewed
• [Journal Article] Prolonged lymphocytopenia after bendamustine therapy in patients with relapsed or refractory indolent B-cell and mantle cell lymphoma (2017)
  • Author(s): Saito H、Maruyama D、Maeshima A M、Makita S、Kitahara H、Miyamoto K、Fukuhara S、Munakata W、Suzuki T、Kobayashi Y、Taniguchi H、Tobinai K
  • Journal Title: Blood Cancer Journal Volume: 7 Issue: 11 Pages: e620-e620
  • DOI: 10.1038/bcj.2017.100
  • Peer Reviewed / Open Access
• [Journal Article] A new peptide vaccine OCV-501: in vitro pharmacology and phase 1 study in patients with acute myeloid leukemia (2017)
  • Author(s): Kobayashi Yukio、Sakura Toru、Miyawaki Shuichi、Toga Kazuyuki、Sogo Shinji、Heike Yuji
  • Journal Title: Cancer Immunology, Immunotherapy Volume: 66 Issue: 7 Pages: 851-863
  • DOI: 10.1007/s00262-017-1981-3
  • Peer Reviewed / Open Access
• [Journal Article] Treatments and outcomes of patients with extranodal natural killer/T-cell lymphoma diagnosed between 2000 and 2013: a cooperative study in Japan (2017)
  • Author(s): Yamaguchi M, Suzuki R, Oguchi M, Asano N, Amaki J, Akiba T, Maeda T, Itasaka S, Kubota N, Saito Y, Kobayashi Y, Itami J, Ueda K, Miyazaki K, Ii N, Tomita N, Sekiguchi N, Takizawa J, Saito B, Murayama T, Ando T, Wada H, Hyo R, Ejima Y, Hasegawa M, Katayama N
  • Journal Title: J Clin Oncol Volume: 35 Issue: 1 Pages: 32-39
  • DOI: 10.1200/jco.2016.68.1619
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] FUS-ERG gene fusion in isolated myeloid sarcoma showing uncommon clinical features. (2016)
  • Author(s): Ueda R, Maruyama D, Nomoto J, Maeshima AM, Fukuhara S, Kitahara H, Miyamoto K, Munakata W, Suzuki T, Taniguchi H, Kobayashi Y, Tobinai K.
  • Journal Title: Oxf Med Case Reports. Volume: 1 Issue: 1 Pages: 4-8
  • DOI: 10.1093/omcr/omv070
  • Peer Reviewed / Open Access
• [Journal Article] Disseminated herpes zoster infection initially presenting with abdominal pain in three lymphoma patients undergoing conventional chemotherapy. (2016)
  • Author(s): Okuma HS, Kobayashi Y, Makita S, Kitahara H, Fukuhara S, Munakata W, Suzuki T, Maruyama D, Tobinai K.
  • Journal Title: Oncolgy Letters Volume: 12 Issue: 2 Pages: 809-814
  • DOI: 10.3892/ol.2016.4683
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinical features and outcomes of 139 Japanese patients with Hodgkin lymphoma. (2016)
  • Author(s): Makita S, Maruyama D, Maeshima AM, Taniguchi H, Miyamoto KI, Kitahara H, Fukuhara S, Munakata W, Kobayashi Y, Itami J, Tobinai K.
  • Journal Title: Int J Hematol. Volume: 印刷中 Issue: 2 Pages: 236-244
  • DOI: 10.1007/s12185-016-2007-1
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinicopathological prognostic factors of 24 patients with B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. (2016)
  • Author(s): Miyamoto KI, Kobayashi Y, Maeshima AM, Taniguchi H, Nomoto J, Kitahara H, Fukuhara S, Munakata W, Maruyama D, Tobinai K.
  • Journal Title: Int J Hematol. Volume: 印刷中 Issue: 6 Pages: 693-702
  • DOI: 10.1007/s12185-016-1989-z
  • Peer Reviewed
• [Journal Article] Classical Hodgkin lymphoma primary refractory to brentuximab vedotin, with transformation to CD30-positive diffuse large B-cell lymphoma. (2016)
  • Author(s): Makita S, Maeshima AM, Taniguchi H, Kitahara H, Fukuhara S, Munakata W, Suzuki T, Maruyama D, Kobayashi Y, Tobinai K.
  • Journal Title: Int J Hematol. Volume: 印刷中 Issue: 3 Pages: 396-399
  • DOI: 10.1007/s12185-016-2018-y
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Clinicopathological features of histological transformation from extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue to diffuse large B-cell lymphoma: an analysis of 467 patients. (2016)
  • Author(s): Maeshima AM, Taniguchi H, Toyoda K, Yamauchi N, Makita S, Fukuhara S, Munakata W, Maruyama D, Kobayashi Y, Tobinai K.
  • Journal Title: Br J Haematol Volume: 174 Issue: 6 Pages: 923-931
  • DOI: 10.1111/bjh.14153
  • Peer Reviewed
• [Journal Article] Prognostic significance of HLA class I and II expression in patients with diffuse large B cell lymphoma treated with standard chemoimmunotherapy. (2016)
  • Author(s): Tada K, Maeshima AM, Hiraoka N, Yamauchi N, Maruyama D, Kim SW, Watanabe T, Katayama N, Heike Y, Tobinai K, Kobayashi Y.
  • Journal Title: Cancer Immunol Immunother Volume: 65 Issue: 10 Pages: 1213-1222
  • DOI: 10.1007/s00262-016-1883-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Influence of the watch and wait strategy on clinical outcomes of patients with follicular lymphoma in the rituximab era. (2016)
  • Author(s): Yuda S, Maruyama D, Maeshima AM, Makita S, Kitahara H, Miyamoto KI, Fukuhara S, Munakata W, Suzuki T, Kobayashi Y, Tajima K, Taniguchi H, Tobinai K.
  • Journal Title: Ann Hematol Volume: 95 Issue: 12 Pages: 2017-2022
  • DOI: 10.1007/s00277-016-2800-1
  • Peer Reviewed
• [Journal Article] Impact of the double expression of MYC and BCL2 on outcomes of localized primary gastric diffuse large B-cell lymphoma patients in the rituximab era. (2016)
  • Author(s): Kawajiri A, Maruyama D, Maeshima AM, Nomoto J, Makita S, Kitahara H, Miyamoto K, Fukuhara S, Suzuki T, Munakata W, Tajima K, Itami J, Taniguchi H, Kobayashi Y, Tobinai K.
  • Journal Title: Blood Cancer J Volume: 6 Issue: 9 Pages: e477-e477
  • DOI: 10.1038/bcj.2016.88
  • Peer Reviewed
• [Journal Article] A retrospective analysis of combination chemotherapy consisting of cyclophosphamide, vincristine, prednisolone and procarbazine (C-MOPP) for pretreated aggressive non-Hodgkin lymphoma. (2015)
  • Author(s): Fukushima R, Kobayashi Y, Fukuhara S, Miyamoto K, Munakata W, Maruyama D, Kim S-W, Watanabe T, Taniguchi H, Maeshima A, Tobinai K.
  • Journal Title: J Chemothera. Volume: 19 Issue: 2 Pages: 1-7
  • DOI: 10.1080/1120009x.2015.1110898
  • Peer Reviewed
• [Presentation] 直腸がん化学療法中に心不全の増悪を契機に診断されたIgM-λ型ALアミロイドーシスの一例． (2018)
  • Author(s): 中世古知昭，小林幸夫，東ヶ崎絵美，野原素直，似鳥修弘，宮田直輝，海老沼浩利，樋口肇，谷口浩久，田村雄一，岡部輝雄，河村朗夫，畠清彦
  • Organizer: 第1回日本腫瘍循環器学会学術集会
• [Presentation] part3:lymphoma Research Advances. Current status in Japan. (2018)
  • Author(s): Yukio Kobayashi
  • Organizer: 6th international conference of FACO
  • Int'l Joint Research
• [Presentation] Genomics of limited-stage diffuse large B-cell lymphoma developing late relapse: analysis of gene alternations in paired primary and late-relapsed tumors by target sequencing. (2018)
  • Author(s): Tomotaka Suzuki, Suguru Fukuhara, Jyunko Nomoto, Satoshi Yamashita, Akiko Miyagi Maeshima, Yuta Ito, Shunsuke Hatta, Sayako Yuda, Shinichi Makita, Wataru Munakata, Tatsuya Suzuki, Dai, Maruyama, Hirokazu Taniguchi, Toshikazu Ushijima, Koji Izutu, Kensei Tobinai, Yukio Kobayashi.
  • Organizer: The 60th American Society of Hematology
  • Int'l Joint Research
• [Presentation] Incidence of risk factors of central nervous system relapse in localized extranodal NK/T-cell lymphoma, nasal type: analysis of NKEA study. (2018)
  • Author(s): Kana Miyazaki, Senzo Taguchi, Masahiko Oguchi, Ritsuro Suzuki, Naoko Asano, Yasuhito Terui, Nobuko Kubota, Yoshihiro Saito, Takeshi Maeda, Satoshi Itasaka, Yukio Kobayashi, Jun Itami, Jun Amaki, Takeshi Akiba, Tohru Murayama, Noriko Ii, Toshinori Soejima, Motoko Yamaguchi, Naoyuki Katayama.
  • Organizer: The 60th American Society of Hematology
  • Int'l Joint Research
• [Presentation] CD56 is an unfavorable prognostic factor for acute promyelocytic leukemia: results by multivariate analysis in the JALSG-APL204 study. (2018)
  • Author(s): Akihiro Takeshita, Norio Asou, Yoshiko Atsuta, Hiroaki Furumaki, Toru Sakura, Yasunori Ueda, Masashi Sawa, Nobuaki Dobashi, Riko Suzuki, Yasuhiro Taniguchi, Masaru Nakagawa, Shigehisa Tamaki, Maki Hagiwara, Katsumichi HFujimaki, Yasuhissa Yokoyama, Hiroyuki Fujita, Masamitu Yanada, Yukio Kobayashi, et al.
  • Organizer: The 60th American Society of Hematology
  • Int'l Joint Research
• [Presentation] Phase Ib study of blinatumomab in Japanese adults with relapsed/refractory ALL. (2018)
  • Author(s): Yukio Kobayshi, John D Morris, Toru Sakura, Catherine A. Tuglus, Min Zhu, Toshihiro Miyamoto, Hiroatsu Iida.
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] Primary refractoryびまん性大細胞型B細胞性リンパ腫の臨床病理学的な検討 (2018)
  • Author(s): 鈴木智貴，丸山大，前島宮城亜希子，野本順子，田島絹子，伊藤勇太，八田俊介，油田さや子，蒔田真一，福原傑，棟方理，鈴木達也，谷口弘和，伊豆津宏二，小林幸夫，飛内賢正．
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] リツキシマブ治療後にCD20が陰転化した再発DLBCLの一例～CD20陰性化の機序に関する考察 (2018)
  • Author(s): 東ヶ崎絵美，中世古知昭, 小林幸夫, 相田真介, 照井康仁, 竹内賢吾, 畠清彦.
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] t(11;18)転座を有するMALTリンパ腫の方法指摘解析結果：長期フォローアップデータ． (2018)
  • Author(s): 豊田康佑，前島亜希子，野本順子，鈴木智貴，油田さや子，山内寛彦，谷口浩和，蒔田真一，福原傑，棟方理，丸山大，飛内賢正, 小林幸夫
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] 濾胞性リンパ腫からびまん性大細胞型リンパ腫への臨床的形質転換を判定するための評価指標． (2018)
  • Author(s): 七條敬文，丸山大，山内寛彦，前島亜希子，菅野雅人，田島絹子，油田さや子，鈴木智貴，豊田康祐，蒔田真一，福原傑，棟方理，鈴木達也，小林幸夫，谷口弘和，南陽介，伊豆津宏二，飛内賢正．
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] 限局期未治療眼付属期原発MALTリンパ腫患者の長期観察結果． (2018)
  • Author(s): 中井りつこ，丸山大，前島亜希子，田島絹子，伊藤勇太，八田俊介，油田さや子，鈴木智貴，蒔田真一，福原傑，棟方理，鈴木達也，伊丹純，鈴木茂伸，対口弘和，小林幸夫，飛内賢正，伊豆津宏二．
  • Organizer: 第80回日本血液学会学術集会
• [Presentation] ALLの治療戦略 (2018)
  • Author(s): 小林幸夫
  • Organizer: 第80回日本血液学会学術集会
  • Invited
• [Presentation] Characterization of MALT lymphoma with t(11;18): long-term follow-up (2018)
  • Author(s): K. Toyoda, AM. Maeshima, J. Nomoto, T. Suzuki, S. Yuda, N. Yamauchi, H. Taniguchi, S. Makita, S. Fukuhara, W. Munakata, D. Maruyama, K. Tobinai1 and Y. Kobayashi1
  • Organizer: EHA
  • Int'l Joint Research
• [Presentation] Comparison of Genetic Profiling of Primary Central Nervous System (CNS) Lymphoma before and after Extra-CNS Relapse (2017)
  • Author(s): Kosuke Toyoda, Junko Nomoto, Yasuji Miyakita, Yoshitaka Narita, Akiko Miyagi Maeshima, Nobuhiko Yamauchi, Suguru Fukuhara, Wataru Munakata, Dai Maruyama, Kensei Tobinai and Yukio Kobayashi
  • Organizer: Blood 2017 130:5135
  • Int'l Joint Research
• [Presentation] 2.Impact of the Double Expression of MYC and BCL2 on Outcomes of Primary Refractory Diffuse Large B-Cell Lymphoma Following R-CHOP Chemoimmunotherapy (2017)
  • Author(s): Tomotaka Suzuki, Dai Maruyama, Akiko Miyagi Maeshima, Kinuko Tajima, Yuta Ito, ShunsukeHatta, Sayako Yuda, Shinichi Makita, Suguru Fukuhara, Wataru Munakata, Tatsuya Suzuki, Hirokazu Taniguchi, Yukio Kobayashi, Koji Izutsu and Kensei Tobinai
  • Organizer: Blood 2017 130:2846
  • Int'l Joint Research
• [Presentation] 3.Improved Prognosis of Extranodal NK/T-Cell Lymphoma, Nasal Type (ENKL) of Nasal Origin but Not Extranasal Origin: An Analysis of NKEA Study (2017)
  • Author(s): M Yamaguchi, R Suzuki, K Miyazaki, J Amaki, J Takizawa, N Sekiguchi, S Inagaki, N Tomita, H Wada, Y Kobayashi, N Niitsu, T Ando, T Maeda, B Saito, H Matsuoka, R Sakai, N Kubota, Y Masaki, N Asano, M Oguchi and Ni Katayama
  • Organizer: Blood 2017 130:1518
  • Int'l Joint Research
• [Presentation] 4.Tamibarotene As Maintenance Therapy for Acute Promyelocytic Leukemia Improved Long Term Relapse-Free Survival: 7-Year Results from a Randomized Controlled Trial, JALSG-APL204 (2017)
  • Author(s): A Takeshita, N Asou, M Yanada, T Sakura, Y Ueda, M Sawa, N Dobashi, M Onizuka, Y Taniguchi, M Nakagawa, S Tamaki, M Hagihara, K Fujimaki, H Furumaki, H Fujita, N Usui, Y Kobayashi, H Kiyoi, S Ohtake, Y Atsuta, I Matsumura, T Naoe and Y Miyazaki
  • Organizer: Blood 2017 130:642
  • Int'l Joint Research
• [Presentation] Phase I Clinical Study of Intravenous Rigosertib in Japanese Patients with Myelodysplastic Syndromes(MDS) (2017)
  • Author(s): Kobayashi Y, et al.
  • Organizer: 日本血液学会
• [Presentation] Treatment guideline in Japan. (2016)
  • Author(s): Kobayashi Y
  • Organizer: JSCO
  • Place of Presentation: パシフィコ横浜, 横浜, 神奈川
  • Year and Date: 2016-10-20
  • Invited
• [Presentation] Treatment and outcomes of patients with NK/T-cell lymphoma diagnosed after 2000, NKEA study. (2016)
  • Author(s): Yamaguchi M, Suzuki R, Oguchi M, Asano N, Amaki J, Kubota N, Kobayashi Y, Ueda K, Miyazaki K, Tomita N, Sekiguchi N, Takizawa J, Saito B, Murayama T, Ando T, Wada H, Hyo R, Hasegawa M, Katayama N.
  • Organizer: JSH
  • Place of Presentation: パシフィコ横浜, 横浜, 神奈川
  • Year and Date: 2016-10-13
• [Presentation] Landscape of MDS genomes as revealed by whole genome sequencing. (2016)
  • Author(s): Nanny Y, Yoshida K, Kataoka K, Nagata Y, Yoshizato T, Kiguchi T, Dobashi N, Usuki K, Naoe T, Kobayashi Y, Kiyoi H, Chiba S, Asou N, Miyazaki Y, Tanaka Y, Chiba K, Shiraishi Y, Miyano S, Ogawa S.
  • Organizer: JSH
  • Place of Presentation: パシフィコ横浜, 横浜, 神奈川
  • Year and Date: 2016-10-13
• [Presentation] Clonal evaluation following azacitidine therapy in patients with high-risk MDS. (2016)
  • Author(s): Takeda J, Yoshida K, Makishima H, Sanya Y, Shiozawa Y, Suzuki H, Shiraishi Y, Okuno Y, Chiba K, Miyano S, Sanada M, Kiguchi T, Dobashi N, Usuki K, Chiba S, Asou N, Miyazaki Y, Naoe T, Kiyoi H, Kobayashi Y, Ogawa S
  • Organizer: JSH
  • Place of Presentation: パシフィコ横浜, 横浜, 神奈川
  • Year and Date: 2016-10-13
• [Presentation] Somatic mutations in newly-diagnosed chronic myeloid leukemia detected by whole-exome sequencing. T (2016)
  • Author(s): Togasaki E, Takeda J, Yoshida K, Shiozawa Y, Takeuchi M, Iwama A, Sakaida E, Hirase C,Shiraishi Y, Chiba K, Tanaka Y, Kiyoi H, Ontake S, Asou N, Kobayashi Y, MiyazakiY, Miyano S, Ogawa S, Matumura I, Nakaseko C, Naoe T.
  • Organizer: JSH
  • Place of Presentation: パシフィコ横浜, 横浜, 神奈川
  • Year and Date: 2016-10-13
• [Presentation] Clinical features and prognosis of unselected patients with AML and RAEB-2: JALSG CS07 study. (2016)
  • Author(s): Miyazaki Y, Sakura T, Yanada M, Takase K, Imai K, Dobashi N, Aoyama Y, Sawa M, Itonaga H, Usuki K, Honda S, Ontake S, Kiyoi H, Onishi K, Kobayashi Y, Naoe T.
  • Organizer: JSH
  • Place of Presentation: パシフィコ横浜, 横浜, 神奈川
  • Year and Date: 2016-10-13
• [Presentation] Response to remission induction therapy can predict the prognosis in de novo AML patients. (2016)
  • Author(s): Ishiyama K, Ohtake S, Miyamura K, Kiyoi H, Miyazaki Y, Kobayashi Y, Usui N, Fujita H, Asou n, Miyawaki S, Naoe T.
  • Organizer: JSH
  • Place of Presentation: パシフィコ横浜, 横浜, 神奈川
  • Year and Date: 2016-10-13
• [Presentation] Azacitidine induced acute lung injury in a Japanes patient with MDS. (2016)
  • Author(s): Makita S, Munakata W, Wattage D, Maeshima AM, Taniguchi H, Toyoda K, Yamauchi N, H\Fukuhara S, Maruyama D, Kobayashi Y, Tobinai K.
  • Organizer: JSH
  • Place of Presentation: パシフィコ横浜, 横浜, 神奈川
  • Year and Date: 2016-10-13
• [Presentation] Long-term treatment by bosutinib in a phase I/II study in Japaness chronic myeloid leukemia patients. (2016)
  • Author(s): Nakaseko C, Takahashi N, Kobayashi Y, Miyamura K, Koide Y, Fujii Y, Onishi K.
  • Organizer: JSH
  • Place of Presentation: パシフィコ横浜, 横浜, 神奈川
  • Year and Date: 2016-10-13
• [Presentation] PDL1, PDL2 expression in Classical Hodgkin lymphoma, primary mediastinal large B cell lymphoma, and lymphoma with intermediate characteristics between Classical Hodgkin lymphoma and primary mediastinal large B cell lymphoma (2016)
  • Author(s): Tanaka Y, Maeshima AM, Nomoto J, Makita S, Fukuhara S, Munakata W, Maruyama D, Tobinai K, Kobayashi Y.
  • Organizer: 2016 ASH Meeting on Lymphoma Biology
  • Place of Presentation: The Broadmoor, Colorado Springs, CO, USA
  • Year and Date: 2016-06-18
  • Int'l Joint Research
• [Book] 造血器腫瘍診療ガイドライン 2018年版 (2018)
  • Author(s): 一般社団法人 日本血液学会
  • Total Pages: 420
  • Publisher: 金原出版
  • ISBN: 9784307101929
• [Book] 脱メチル化薬を用いた悪性腫瘍治療の展望 エピゲノム研究修飾の全体像の理解から先制・個別化医療へ． (2016)
  • Author(s): 小林幸夫
  • Publisher: 羊土社