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Analysis on molecular mechanism of mesangial proliferative glomerulonephritis

Research Project

Project/Area Number 16K10060
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionThe University of Tokyo

Principal Investigator

Tsurumi Haruko  東京大学, 医学部附属病院, 登録研究員 (20632269)

Co-Investigator(Kenkyū-buntansha) 張田 豊  東京大学, 医学部附属病院, 准教授 (10451866)
服部 元史  東京女子医科大学, 医学部, 教授 (50192274)
神田 祥一郎  東京大学, 医学部附属病院, 助教 (60632651)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords糸球体腎炎 / メサンギウム細胞 / 膜性増殖性糸球体腎炎 / 細胞・組織
Outline of Final Research Achievements

In kidney, glomerular injury results in proliferation and aberrant migration of mesangial cells, which is the pathological characteristic of mesangial proliferative glomerulonephritis. To date, molecular changes that occur in mesangial cells during glomerular injury and their association with the pathogenesis of glomerulonephritis remain largely unclear. We identified expression of a novel molecule(X) in mesangial cells in vivo and in vitro. In kidney tissues from some patients with mesangioproliferative glomerulonephritis, expression of X in glomerlar mesangium was altered. In cultured mesangial cells, X was localized in intracellular vesicles, and involved in endocytosis of extracellular matrix. These result suggested the involvement of novel molecules in pathogenesis of glomerulonephritis.

Academic Significance and Societal Importance of the Research Achievements

小児の腎臓病の代表である糸球体腎炎がどのようにして発症し進展するのかについては不明な点が多い。この研究ではメサンギウム細胞が病的な刺激に応じてどのように変化するのかを明らかにすることで腎炎の発症メカニズムの解明を目指した。メサンギウム細胞に存在する分子を新たに同定し、その分子の発現が一部の腎炎患者で変化すること、またその分子の機能がメサンギウム部分の変化に関連する可能性が示唆された。糸球体腎炎の発症に関連する変化を明らかにした。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Application of next-generation sequencing technology to diagnosis and treatment of focal segmental glomerulosclerosis2018

    • Author(s)
      Harita Yutaka
    • Journal Title

      Clin Exp Nephrol.

      Volume: 印刷中 Issue: 3 Pages: 491-500

    • DOI

      10.1007/s10157-017-1449-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 腎疾患に対する遺伝子診断2018

    • Author(s)
      張田豊
    • Journal Title

      小児科

      Volume: 59 Pages: 1379-1385

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 小児腎疾患における遺伝子診断の実際2018

    • Author(s)
      張田豊
    • Journal Title

      日本小児腎不全学会雑誌

      Volume: 38 Pages: 28-33

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 遺伝子から見た嚢胞性腎疾患2018

    • Author(s)
      張田豊
    • Journal Title

      じん

      Volume: 40 Pages: 4-8

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Amnionless-mediated glycosylation is crucial for cell surface targeting of cubilin in renal and intestinal cells2018

    • Author(s)
      Udagawa Tomohiro、Harita Yutaka、Miura Kenichiro、Mitsui Jun、Ode Koji L.、Morishita Shinichi、Urae Seiya、Kanda Shoichiro、Kajiho Yuko、Tsurumi Haruko、Ueda Hiroki R.、Tsuji Shoji、Saito Akihiko、Oka Akira
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 2351-2351

    • DOI

      10.1038/s41598-018-20731-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered expression of Crb2 in podocytes expands a variation of CRB2 mutations in steroid-resistant nephrotic syndrome.2017

    • Author(s)
      Udagawa T, Jo T, Yanagihara T, Shimizu A, Mitsui J, Tsuji S, Morishita S, Onai R, Miura K, Kanda S, Kajiho Y, Tsurumi H, Oka A, Hattori M, Harita Y.
    • Journal Title

      Pediatric Nephrology

      Volume: 32 Issue: 5 Pages: 801-809

    • DOI

      10.1007/s00467-016-3549-4

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 蛋白尿・ネフローゼの発症機序2018

    • Author(s)
      張田豊
    • Organizer
      北海道小児腎臓病研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Pathogenic mechanism of childhood idiopathic nephrotic syndrome2018

    • Author(s)
      Yutaka Harita
    • Organizer
      ISN FRONTIERS MEETINGS
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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