Elucidation the promoter of ductus arteriosus remodeling in fetal sheep
| Project/Area Number |
16K10085
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北西 龍太 東北大学, 医学系研究科, 非常勤講師 (20436116)
埴田 卓志 東北大学, 大学病院, 助教 (30400360)
松田 直 東北大学, 医学系研究科, 非常勤講師 (50361100)
渡邊 真平 東北大学, 大学病院, 助手 (70509413)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 動脈管 / 内膜肥厚 / ヒツジ / 胎児 / 子宮内炎症 / 早産児 / 動脈管開存症 / 血管リモデリング / 炎症 |
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| Outline of Final Research Achievements |
The study was performed to make clear that the intrauterine inflammation could promote intimal thickening development of fetal ductus arteriosus using chronically instrumented premature fetal sheep. The fetuses were divided into two groups; control and inflammation groups (each n=5). After the autopsy, we carried out histological examination. The ratio (mean±SEM) of intimal thickening area to the cross-sectional area was compared between the two groups. There was no difference between the control (0.0372±0.0034) and inflammation group (0.0322±0.0032). Moreover, no difference was found between the two in the developmental score. The results could not suggest that the intrauterine inflammation would promote intimal thickening development of fetal ductus arteriosus.
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| Academic Significance and Societal Importance of the Research Achievements |
超早産児の予後を改善する上では動脈管の内膜肥厚を促進させる治療の開発がきわめて重要であるが，未だそのような臨床研究報告は国内外においてなされていない．本研究では子宮内炎症が動脈管の内膜組織を成熟させると仮定し検証を行ったが，証明することはできなかった．しかし結果から高乳酸血症をきたすような慢性的な低酸素により内膜肥厚が促進される可能性が示唆された．本研究は動脈管の内膜肥厚を促進させる治療を開発する臨床研究のための橋渡し的研究となった．
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Report
(4 results)
Research Products
(1 results)
