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Verification of depression onset mechanism by 2-hit stress model

Research Project

Project/Area Number 16K10194
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionTokyo Medical University

Principal Investigator

INOUE TAKESHI  東京医科大学, 医学部, 主任教授 (70250438)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords小児期虐待 / いじめ / 反すう / 睡眠 / 職業性ストレス / プレゼンティズム / うつ病 / 認知機能 / 小児期養育体験 / 特性不安 / 感情気質 / 自尊感情 / ネグレクト / 主観的社会的地位 / 神経症的特質 / 対人関係敏感性 / 虐待 / パーソナリティ / ストレス / 不安
Outline of Final Research Achievements

We collected data of psychosocial factors of a large number of general adults, and analyzed the effects of childhood experiences, personality traits, adult stress, and sleep on depressive symptoms, anxiety symptoms, subjective health, QOL, and presentism by multivariate analysis. Statistical analyses were conducted to clarify the moderator and mediator effects of these factors. Childhood abuse, childhood parenting (care and overprotection), and being bullied affected anxiety symptoms, depressive symptoms, and well-being through self-esteem, trait anxiety, neuroticism, affective temperament, and interpersonal sensitivity. It affected the sense of health. Moreover, subjective social status has influenced the mediating action of these personality traits. It also became clear that occupational stress is influenced by childhood experiences, resilience, neuroticism and clonotype, and that the effect of occupational stress on the presentism is mediated by the influence on sleep.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果から、現在社会問題となっている小児期の虐待や育児放棄、いじめが将来の成人の精神保健や職業性ストレスに影響を与えることが明らかになった。したがって、小児期の育児・教育の支援が我が国の精神保健と産業衛生改善につながること示唆される。さらに、この影響は様々なパーソナリティ特性を介した間接効果でもあることから、思春期・青年期におけるパーソナリティ特性の評価に基づいて介入を行うことが、事後に小児期虐待・育児放棄の影響を回復するきっかけになることも示唆される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (29 results)

All 2019 2018 2017 2016

All Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 15 results,  Open Access: 6 results) Presentation (13 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] Associations between cognitive impairment and quality of life in euthymic bipolar patients2019

    • Author(s)
      Toyoshima Kuniyoshi、Kako Yuki、Toyomaki Atsuhito、Shimizu Yusuke、Tanaka Teruaki、Nakagawa Shin、Inoue Takeshi、Martinez-Aran Anabel、Vieta Eduard、Kusumi Ichiro
    • Journal Title

      Psychiatry Research

      Volume: 271 Pages: 510-515

    • DOI

      10.1016/j.psychres.2018.11.061

    • NAID

      120006776820

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Subjective social status via mediation of childhood parenting is associated with adulthood depression in non-clinical adult volunteers.2019

    • Author(s)
      Hayashida T, Higashiyama M, Sakuta K, Masuya J, Ichiki M, Kusumi I, Inoue T
    • Journal Title

      Psychiatry Research

      Volume: 274 Pages: 352-357

    • DOI

      10.1016/j.psychres.2019.02.061

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive assessment of the impact of life habits on sleep disturbance, chronotype, and daytime sleepiness among high-school students2018

    • Author(s)
      Shimura Akiyoshi、Hideo Sakai、Takaesu Yoshikazu、Nomura Ryota、Komada Yoko、Inoue Takeshi
    • Journal Title

      Sleep Medicine

      Volume: 44 Pages: 12-18

    • DOI

      10.1016/j.sleep.2017.10.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circadian Rhythm Sleep-Wake Disorders Predict Shorter Time to Relapse of Mood Episodes in Euthymic Patients With Bipolar Disorder2018

    • Author(s)
      Takaesu Yoshikazu、Inoue Yuichi、Ono Kotaro、Murakoshi Akiko、Futenma Kunihiro、Komada Yoko、Inoue Takeshi
    • Journal Title

      The Journal of Clinical Psychiatry

      Volume: 79 Issue: 1 Pages: 17m11565-17m11565

    • DOI

      10.4088/jcp.17m11565

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of trait anxiety, child maltreatment, and adulthood life events on depressive symptoms2018

    • Author(s)
      Uchida Yoshihiro、Takahashi Toshinao、Katayama Shigemasa、Masuya Jiro、Ichiki Masahiko、Tanabe Hajime、Kusumi Ichiro、Inoue Takeshi
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: 14 Pages: 3279-3287

    • DOI

      10.2147/ndt.s182783

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Affective temperaments play an important role in the relationship between child abuse and the diagnosis of bipolar disorder2018

    • Author(s)
      Toda Hiroyuki、Inoue Takeshi、Tanichi Masaaki、Saito Taku、Nakagawa Shin、Masuya Jiro、Tanabe Hajime、Yoshino Aihide、Kusumi Ichiro
    • Journal Title

      Psychiatry Research

      Volume: 262 Pages: 13-19

    • DOI

      10.1016/j.psychres.2018.01.040

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Circadian rhythm sleep-wake disorders as predictors for bipolar disorder in patients with remitted mood disorders2017

    • Author(s)
      Takaesu Yoshikazu、Inoue Yuichi、Ono Kotaro、Murakoshi Akiko、Futenma Kunihiro、Komada Yoko、Inoue Takeshi
    • Journal Title

      Journal of Affective Disorders

      Volume: 220 Pages: 57-61

    • DOI

      10.1016/j.jad.2017.05.041

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between suicide-related ideations and affective temperaments in the Japanese general adult population2017

    • Author(s)
      Mitsui Nobuyuki、Nakai Yukiei、Inoue Takeshi、Udo Niki、Kitagawa Kan、Wakatsuki Yumi、Kameyama Rie、Toyomaki Atsuhito、Ito Yoichi M.、Kitaichi Yuji、Nakagawa Shin、Kusumi Ichiro
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 6 Pages: e0179952-e0179952

    • DOI

      10.1371/journal.pone.0179952

    • NAID

      120006337771

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The mediator effect of personality traits on the relationship between childhood abuse and depressive symptoms in schizophrenia2017

    • Author(s)
      Okubo Ryo、Inoue Takeshi、Hashimoto Naoki、Suzukawa Akio、Tanabe Hajime、Oka Matsuhiko、Narita Hisashi、Ito Koki、Kako Yuki、Kusumi Ichiro
    • Journal Title

      Psychiatry Research

      Volume: 257 Pages: 126-131

    • DOI

      10.1016/j.psychres.2017.06.039

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Re-analysis of the association of temperature or sunshine with hyperthymic temperament using lithium levels of drinking water2017

    • Author(s)
      Matsuzaki Hideki、Terao Takeshi、Inoue Takeshi、Takaesu Yoshikazu、Ishii Nobuyoshi、Kohno Kentaro、Takeshima Minoru、Baba Hajime、Honma Hiroshi
    • Journal Title

      Journal of Affective Disorders

      Volume: 223 Pages: 126-129

    • DOI

      10.1016/j.jad.2017.07.039

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interpersonal sensitivity mediates the effects of child abuse and affective temperaments on depressive symptoms in the general adult population2017

    • Author(s)
      Otsuka Ayano、Takaesu Yoshikazu、Sato Mitsuhiko、Masuya Jiro、Ichiki Masahiko、Kusumi Ichiro、Inoue Takeshi
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: Volume 13 Pages: 2559-2568

    • DOI

      10.2147/ndt.s144788

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Childhood parental bonding affects adulthood trait anxiety through self-esteem2017

    • Author(s)
      Shimura A, Takaesu Y, Nakai Y, Murakoshi A, Ono Y, Matsumoto Y, Kusumi I, Inoue T
    • Journal Title

      Compr Psychiatry

      Volume: 74 Pages: 15-20

    • DOI

      10.1016/j.comppsych.2016.12.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associations among depressive symptoms, childhood abuse, neuroticism, and adult stressful life events in the general adult population2017

    • Author(s)
      Ono K, Takaesu Y, Nakai Y, Shimura A, Ono Y, Murakoshi A, Matsumoto Y, Tanabe H, Kusumi I, Inoue T
    • Journal Title

      Neuropsych. Dis. Treat.

      Volume: 13 Pages: 477-482

    • DOI

      10.2147/ndt.s128557

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The influence of parental care and overprotection, neuroticism and adult stressful life events on depressive symptoms in the general adult population2017

    • Author(s)
      Ono Y, Takaesu Y, Nakai Y, Ichiki M, Masuya J, Kusumi I, Inoue T
    • Journal Title

      J Affect Disord

      Volume: 217 Pages: 66-72

    • DOI

      10.1016/j.jad.2017.03.058

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] The influence of childhood abuse, adult life events, and affective temperaments on the well-being of the general, non-clinical adult population2016

    • Author(s)
      Kanai Y, Takaesu Y, Nakai Y, Ichiki M, Sato M, Matsumoto Y, Ishikawa J, Ono Y, Murakoshi A, Tanabe H, Kusumi I, Inoue T
    • Journal Title

      Neuropsych. Dis. Treat.

      Volume: 12 Pages: 823-832

    • DOI

      10.2147/ndt.s100474

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] うつ病におけるパーソナリティとストレスの相互作用2018

    • Author(s)
      井上 猛
    • Organizer
      第15回日本うつ病学会総会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 夜型のクロノタイプを持つ者の早すぎる起床時刻はプレゼンティーイズムを招く2018

    • Author(s)
      志村哲祥、杉浦航、林田泰斗、大野浩太郎、岬昇平、古井裕司、井上 猛
    • Organizer
      第91回日本産業衛生学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 虐められた体験が、神経症的傾向を介して、うつ病患者のうつ症状に影響する2018

    • Author(s)
      館脩一郎、浅水美紀、黒川 達也、桝屋二郎、木内健二郎、片山成仁、井上猛
    • Organizer
      第15回日本うつ病学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小児期の被養育体験、特性不安、ライフイベントが抑うつ症状に与える複合的影響の検討2018

    • Author(s)
      林田泰斗、東山 幹、内田由寛、大野浩太郎、村越晶子、市来真彦、井上 猛
    • Organizer
      第114回日本精神神経学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小児期の被養育体験とレジリアンスが職業性ストレスに与える複合的影響の検討2018

    • Author(s)
      鮫島寛人、成瀬麻、志村哲祥、桝屋二郎、市来真彦、中島聡美、井上 猛
    • Organizer
      東京精神医学会第115回学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 精神医学と心身医学におけるストレス脆弱性の臨床的意義2017

    • Author(s)
      井上 猛
    • Organizer
      第58回日本心身医学会総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 一般成人におけるうつ症状に及ぼす、特性不安、小児期虐待、成人期ライフイベントの影響2017

    • Author(s)
      内田 由寛、高橋寿直、黒川達也、片山 成仁、井上 猛
    • Organizer
      第113回日本精神神経学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 小児期の虐待、感情気質、主観的社会的地位の抑うつ症状に与える複合的影響の検討2017

    • Author(s)
      東山 幹、高江洲義和、林田泰斗、井上 猛
    • Organizer
      第113回日本精神神経学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 主観的社会的地位が抑うつ症状に与える複合的影響の検討2017

    • Author(s)
      林田泰斗、高江洲義和、東山 幹、井上 猛
    • Organizer
      第113回日本精神神経学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 成人の抑うつ症状に対する小児期の両親の養育態度、対人関係敏感性、ライフイベントの相互作用の検討2017

    • Author(s)
      岩尾 紅子、高江洲 義和、市来 真彦、桝屋二郎、引場  智、高橋 伸忠、井上 猛
    • Organizer
      第14回日本うつ病学会総会/第17回日本認知療法・認知行動療法学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 一般成人におけるうつ症状と幼少期ストレス、神経症的特質、ライフイベントの関連2016

    • Author(s)
      大野 浩太郎、高江洲 義和、大塚 綾乃、瀧田千歌、市来真彦、井上 猛
    • Organizer
      第13回日本うつ病学会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-08-05
    • Related Report
      2016 Research-status Report
  • [Presentation] 一般成人における抑うつ症状に対する対人関係敏感性、小児期虐待、感情気質の複合的影響に関するパス解析2016

    • Author(s)
      大塚 綾乃、高江洲 義和、井上 猛
    • Organizer
      第13回日本うつ病学会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-08-05
    • Related Report
      2016 Research-status Report
  • [Presentation] 一般成人におけるうつ症状に対する両親の養育態度2016

    • Author(s)
      小野泰之、高江洲義和、村越晶子、志村哲祥、大塚綾乃、大野浩太郎、赤羽学爾、市来真彦、井上 猛
    • Organizer
      第46回日本神経精神薬理学会
    • Place of Presentation
      ソウル
    • Year and Date
      2016-07-02
    • Related Report
      2016 Research-status Report
  • [Book] 医師と患者・家族をつなぐ うつ病のABC;早期発見・早期治療のために2018

    • Author(s)
      井上 猛、小野泰之、大野浩太郎
    • Total Pages
      147
    • Publisher
      医薬ジャーナル社
    • ISBN
      9784753228560
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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