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Evaluation of the pathogenesis of hypersomnolence and psychosis disorders caused by auto-antibodies

Research Project

Project/Area Number 16K10203
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionAkita University

Principal Investigator

Kanbayashi Takashi  秋田大学, 医学系研究科, 准教授 (50323150)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords睡眠覚醒障害 / 抗NMDA受容体脳炎 / orexin / narcolepsy / NMDA encephalitis / AQP4 antibody / GFAP / ナルコレプシー / NMDA受容体脳炎 / 精神生理学 / オレキシン
Outline of Final Research Achievements

Of the 36 NMO cases, 28 were positive for AQP4 antibody, 8 were negative, and 2 were negative for MOG. Orexin levels were relatively high in MOG positive cases. In both cases where both antibodies were negative, improvement in orexin levels after treatment was poor.
NMDAR antibody was positive in 14 out of 169 cases. Seven of the 14 cases had encephalitis and were initially diagnosed with tension disease. The other 7 cases were cases of only mental symptoms without neurological symptoms, and psychiatric diagnosis was 3 cases of tension disorders, 2 cases of short-term mental disorders and 2 cases of schizophrenia. In 25 sleep disorders, 6 positive cases were found. 5 were narcolepsy and 1 was recurrent hypersomnia in these 6 positive cases.

Academic Significance and Societal Importance of the Research Achievements

オレキシン神経障害を来して、過眠症状を示すNMO36症例のうちで、AQP4抗体陽性例は28例と大部分を占めている。NMOの国際診断基準の中核症状の1つにも過眠症状があげられており、頻度が高いことは妥当な結果と思われる。NMDAR抗体が精神症状のみの7例で陽性であったことは特筆すべきことであり、統合失調症と考えられていた症例のうちで、僅かではあるが神経抗体により症状が発現している症例が存在することになる。睡眠障害に精神症状を呈した症例でも陽性例があり、抗体による精神症状の発現は希有な物ではないと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (68 results)

All 2019 2018 2017 2016

All Journal Article (41 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 24 results,  Open Access: 10 results) Presentation (26 results) (of which Int'l Joint Research: 7 results,  Invited: 6 results) Book (1 results)

  • [Journal Article] Normal CSF orexin levels in the patients with hypersomnolence following HPV vaccination2019

    • Author(s)
      Imanishi, A., Kanbayashi, T., Sagawa, Y. et al.
    • Journal Title

      Sleep Biol. Rhythms

      Volume: 17 Issue: 2 Pages: 259

    • DOI

      10.1007/s41105-019-00210-7

    • NAID

      40021864121

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of symptomatic narcolepsy or hypersomnia: an analysis of 182 consecutive cases with neurological disorders associated with hypersomnolence2019

    • Author(s)
      Ono, H., Kanbayashi, T., Imanishi, A. et al.
    • Journal Title

      Sleep Biol. Rhythms

      Volume: 17 Issue: 1 Pages: 123-140

    • DOI

      10.1007/s41105-018-0186-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical significance of assaying anti-MOG antibody in cerebrospinal fluid in MOG-antibody-associated diseases: A case report.2019

    • Author(s)
      Aoe S, Kume K, Takata T, Touge T, Kaneko K, Nakashima I, Deguchi K, Masaki T.
    • Journal Title

      Mult Scler Relat Disord.

      Volume: 28 Pages: 165-166

    • DOI

      10.1016/j.jocn.2019.03.066

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement of cerebrospinal fluid orexin-A (hypocretin-1) by enzyme-linked immunosorbent assay: A comparison with radioimmunoassay.2018

    • Author(s)
      Ono T, Kanbayashi T, Yoshizawa K, Nishino S, Shimizu T
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 72 Issue: 11 Pages: 849-850

    • DOI

      10.1111/pcn.12780

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Fluctuating CSF hypocretin-1 levels in mild brain trauma-induced Kleine-Levin syndrome.2018

    • Author(s)
      Usuda M, Kodaira M, Ogawa Y, Kanbayashi T, Yanagisawa S, Sekijima Y.
    • Journal Title

      J Neurol Sci.

      Volume: 391 Pages: 10-11

    • DOI

      10.1016/j.jns.2018.05.011

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid orexin-A levels in systemic lupus erythematosus patients presenting with excessive daytime sleepiness.2018

    • Author(s)
      Suzuki K, Miyamoto M, Miyamoto T, Matsubara T, Inoue Y, Iijima M, Mizuno S, Horie J, Hirata K, Shimizu T, Kanbayashi T.
    • Journal Title

      Lupus.

      Volume: 11 Issue: 11 Pages: 1847-1853

    • DOI

      10.1177/0961203318778767

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orexin/hypocretin levels in the cerebrospinal fluid and characteristics of patients with myotonic dystrophy type 1 with excessive daytime sleepiness2018

    • Author(s)
      Omori Yuki、Kanbayashi Takashi、Imanishi Aya、Tsutsui Ko、Sagawa Yohei、Kikuchi Yuka S、Takeshima Masahiro、Yoshizawa Kazuhisa、Uemura Sachiko、Shimizu Tetsuo
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: Volume 14 Pages: 451-457

    • DOI

      10.2147/ndt.s158651

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【睡眠障害と精神科医療】 過眠症の診断と治療2018

    • Author(s)
      大森 佑貴, 神林 崇
    • Journal Title

      日本精神科病院協会雑誌

      Volume: 37(8) Pages: 840-845

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 社会学 女性の睡眠負債2018

    • Author(s)
      小野 太輔, 大倉 睦美, 神林 崇
    • Journal Title

      睡眠医療

      Volume: 12(3) Pages: 319-324

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 抗Ma2抗体陽性であり、精巣腫瘍を認めた症候性ナルコレプシー患者の一例2018

    • Author(s)
      今西 彩, 成田 恵理子, 池田 祐介, 山辺 拓也, 神林 崇, 清水 徹男
    • Journal Title

      睡眠医療

      Volume: 12(1) Pages: 85-89

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orexin/hypocretin levels in the cerebrospinal fluid and characteristics of patients with myotonic dystrophy type 1 with excessive daytime sleepiness.2018

    • Author(s)
      Omori Y, Kanbayashi T, Imanishi A, Tsutsui K, Sagawa Y, Kikuchi YS, Takeshima M, Yoshizawa K, Uemura S, Shimizu T.
    • Journal Title

      Neuropsychiatr Dis Treat

      Volume: 14 Pages: 451-457

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Experience with a Dual Orexin Receptor Antagonist, Suvorexant (Belsomra) in Japan.2018

    • Author(s)
      Ono H, Kanbayashi T, Iwaki S, Takahashi J, Imanishi A, Sagawa Y, Tsutsui K, Omori Y, Nishino S, Shimizu T.
    • Journal Title

      J Sleep Disord Med Care

      Volume: 1(1)

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Low dose of aripiprazole advanced sleep rhythm and reduced nocturnal sleep time in the patients with delayed sleep phase syndrome: an open-labeled clinical observation2018

    • Author(s)
      Omori Y, Kanbayashi T, Sagawa Y, Imanishi A, Tsutsui K, Takahashi Y, Takeshima M, Takaki M, Nishino S, Shimizu T.
    • Journal Title

      Neuropsychiatr Dis Treat in press

      Volume: ー

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Continuous intrathecal orexin delivery inhibits cataplexy in a murine model of narcolepsy2018

    • Author(s)
      Kaushik MK, Aritake K, Imanishi A, Kanbayashi T, Ichikawa T, Shimizu T, Urade Y, Yanagisawa M.
    • Journal Title

      PNSA in press

      Volume: ー

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cerebrospinal fluid orexin-A levels in systemic lupus erythaematosus patients presenting with excessive daytime sleepiness2018

    • Author(s)
      Suzuki K, Miyamoto M, Miyamoto T, Matsubara T, Inoue Y, Iijima M, Mizuno S, Horie J, Hirata K, Shimizu T, Kanbayashi T.
    • Journal Title

      Lupus in press

      Volume: ー

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] N-Methyl-D-aspartate receptor antibody could be a cause of catatonic symptoms in psychiatric patients: case reports and methods for detection.2017

    • Author(s)
      Tsutsui K, Kanbayashi T, Takaki M, Omori Y, Imai Y, Nishino S, Tanaka K, Shimizu T.
    • Journal Title

      Neuropsychiatric Dis Treat.

      Volume: 13 Pages: 339-345

    • DOI

      10.2147/ndt.s125800

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Residual effects of eszopiclone and placebo in healthy elderly subjects: a randomized double-blind study2017

    • Author(s)
      Takahashi Jun、Kanbayashi Takashi、Ito Uemura Sachiko、Sagawa Youhei、Tsutsui Kou、Takahashi Yuya、Omori Yuki、Imanishi Aya、Takeshima Masahiro、Satake Masahiro、Shimizu Tetsuo
    • Journal Title

      Sleep and Biological Rhythms

      Volume: 15 Issue: 3 Pages: 235-241

    • DOI

      10.1007/s41105-017-0101-2

    • NAID

      40021252525

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute effects of zaleplon on daytime functions on the following day: psychomotor and physical performances, arousal levels and mood2017

    • Author(s)
      ITO W, KANBAYASHI T, SHIMIZU K, UEMURA SI, WAKASA M, INOUE Y, SHIMIZU T, NISHINO S
    • Journal Title

      Gazzetta Medica Italiana Archivio per le Scienze Mediche

      Volume: 176(5) Pages: 257-64

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 「精神医学」への手紙 うつ病へのアリピプラゾールの増強療法の効果が「中折れ」したときの対応2017

    • Author(s)
      神林 崇、大森 佑貴
    • Journal Title

      精神医学

      Volume: 59(10) Pages: 979-981

    • NAID

      40021339499

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 抑うつ症状を伴う睡眠相後退症候群に対するaripiprazoleの有効性の単群試験による検討2017

    • Author(s)
      大森 佑貴, 神林 崇, 高木 学, 筒井 幸, 高橋 裕哉, 佐川 洋平, 今西 彩, 高橋 淳, 小野 太輔, 清水 徹男
    • Journal Title

      精神科治療学

      Volume: 32(6) Pages: 831-834

    • NAID

      40021246081

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 睡眠障害診療29のエッセンス  過眠障害 過眠症診療の実際2017

    • Author(s)
      小野 太輔, 神林 崇
    • Journal Title

      医学のあゆみ 別冊

      Volume: ー Pages: 121-126

    • Related Report
      2017 Research-status Report
  • [Journal Article] 【精神医学症候群(第2版)-不安症から秩序破壊的・衝動制御・素行症まで-】 睡眠-覚醒障害群 ナルコレプシー2017

    • Author(s)
      大森 佑貴, 今西 彩, 竹越 結生, 神林 崇, 清水 徹男
    • Journal Title

      日本臨床別冊

      Volume: ー Pages: 367-373

    • Related Report
      2017 Research-status Report
  • [Journal Article] 【オレキシン受容体拮抗薬の臨床的意義と今後への期待】 オレキシンと過眠症2017

    • Author(s)
      佐川 洋平, 神林 崇
    • Journal Title

      睡眠医療

      Volume: 11(1) Pages: 27-34

    • Related Report
      2017 Research-status Report
  • [Journal Article] 【睡眠障害:超高齢社会における実態とその対策】 高齢不眠症患者への薬物療法2017

    • Author(s)
      和田 大和, 澤田 将幸, 黒田 健治, 神林 崇
    • Journal Title

      Pharma Medica

      Volume: 35(3) Pages: 39-43

    • Related Report
      2017 Research-status Report
  • [Journal Article] 【分子精神医学の最前線】2017

    • Author(s)
      小野 太輔, 神林 崇, 佐川 洋平, 今西 彩, 清水 徹男
    • Journal Title

      オレキシン精神科

      Volume: 30(1) Pages: 68-74

    • Related Report
      2017 Research-status Report
  • [Journal Article] Anti-Inflammatory Therapy and Immunotherapy Were Partially Effective in a Patient With Anti-N-Methyl-D-Aspartate Receptor Antibodies and a Special Subgroup of Treatment-Resistant Schizophrenia.2016

    • Author(s)
      Senda M, Bessho K, Oshima E, Sakamoto S, Tanaka K, Tsutsui K, Kanbayashi T,Takaki M, Yoshimura B.
    • Journal Title

      J Clin Psychopharmacol.

      Volume: 36 Issue: 1 Pages: 92-93

    • DOI

      10.1097/jcp.0000000000000439

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decline of CSF Orexin (Hypocretin) Levels in Prader-Willi Syndrome.2016

    • Author(s)
      Mayu Omokawa, Tadayuki Ayabe, Toshiro Nagai, Aya Imanishi, Ayumi Omokawa, Seiji Nishino, Yohei Sagawa, Tetsuo Shimizu, Takashi Kanbayashi.
    • Journal Title

      American Journal of Medical Genetics part A

      Volume: 170 Issue: 5 Pages: 1181-1186

    • DOI

      10.1002/ajmg.a.37542

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hypocretin-1 levels in the cerebrospinal fluid of patients with Percheron artery infarction with or without midbrain involvement.2016

    • Author(s)
      Suzuki K, Miyamoto T, Miyamoto M, Maeda H, Nokura K, Tohyama J, Hirata K, Shimizu T, Kanbayashi T.
    • Journal Title

      Medicine (Baltimore)

      Volume: 95(29) Issue: 29 Pages: e4281-e4281

    • DOI

      10.1097/md.0000000000004281

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] NEUROPSYCHOLOGICAL CORRELATES OF REGIONAL CEREBRAL BLOOD FLOW IN ALZHEIMER'S DISEASE USING CORRELATION IMAGING PLOTS.2016

    • Author(s)
      Takano D, Yamazaki T, Nagata K, Kanbayashi T, Shimizu T.
    • Journal Title

      秋田医学

      Volume: 43(2) Pages: 65-78

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【小児内分泌学の進歩2016】 糖代謝異常・肥満 プラダー・ウィリ症候群の日中過眠は視床下部のオレキシン機能低下が原因である.2016

    • Author(s)
      綾部 匡之,面川 真由,大戸 佑二,村上 信行,井原 裕,神林 崇,永井 敏郎
    • Journal Title

      ホルモンと臨床

      Volume: 63(1) Pages: 37-40

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 精神症状を呈した再発性多発軟骨炎の1例.2016

    • Author(s)
      大森 佑貴, 草薙 宏明, 筒井 幸, 高橋 淳, 安宅 慶一郎, 奈良 瑞穂, 利川 嘉明, 大谷 隆浩, 高橋 聡, 齋藤 英知, 神林 崇, 清水 徹男
    • Journal Title

      精神科治療学

      Volume: 31(2) Pages: 247-253

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 睡眠障害と関連した心・身疾患の豆知識(第8回) 中枢性過眠症と神経免疫疾患 脱髄性疾患および抗AQP4抗体,抗Ma2抗体,抗NMDA受容体抗体による脳症.2016

    • Author(s)
      今西 彩,神林 崇,久保田 弘樹,筒井 幸,佐川 洋平,竹島 正浩,大森 佑貴,高橋 裕哉,小野 太輔,清水 徹男
    • Journal Title

      睡眠医療

      Volume: 10(4) Pages: 591-597

    • NAID

      40021051244

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【分子精神医学の最前線】 オレキシン.2016

    • Author(s)
      小野 太輔,神林 崇,佐川 洋平,今西 彩,清水 徹男
    • Journal Title

      精神科

      Volume: 30(1) Pages: 68-74

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【統合失調症のベストプラクティス】 (第II部)各論 統合失調症との類縁/鑑別病態再検討 統合失調症と抗NMDA受容体脳炎との鑑別.2016

    • Author(s)
      筒井 幸,神林 崇,田中 惠子,清水 徹男
    • Journal Title

      精神科治療学

      Volume: 31supl Pages: 377-380

    • Related Report
      2016 Research-status Report
  • [Journal Article] オレキシン研究の進歩と睡眠医療への貢献.2016

    • Author(s)
      小野 宏晃,岡島 義,上村 佐知子,神林 崇
    • Journal Title

      日本臨床生理学会雑誌

      Volume: 46(3) Pages: 107-114

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【睡眠障害と臨床検査】 過眠症の基礎と検査.2016

    • Author(s)
      大森 佑貴,神林 崇,今西 彩,山田 康子,清水 徹男
    • Journal Title

      臨床検査

      Volume: 60(9) Pages: 940-945

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【睡眠障害:超高齢社会における実態とその対策】 高齢不眠症患者への薬物療法.2016

    • Author(s)
      和田 大和,澤田 将幸,黒田 健治,神林 崇
    • Journal Title

      Pharma Medica

      Volume: 35(3) Pages: 39-43

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【抗NMDA受容体脳炎】 抗NMDA受容体脳炎の概念.2016

    • Author(s)
      筒井 幸,神林 崇,田中 惠子,清水 徹男
    • Journal Title

      精神科

      Volume: 28(6) Pages: 488-491

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【睡眠診療最前線 より良質な眠りを届けるために】 睡眠薬の特徴 オレキシン受容体拮抗薬登場で選択肢が広がる.2016

    • Author(s)
      和田 大和,吉田 祥,黒田 健治,神林 崇
    • Journal Title

      メディカル朝日

      Volume: 45(2) Pages: 16-17

    • Related Report
      2016 Research-status Report
  • [Journal Article] 【職場のメンタルヘルスの不調に気づく】 知っておくとタメになる、専門医の対応 「職場の不眠」への対応.2016

    • Author(s)
      吉田 祥,神林 崇
    • Journal Title

      Modern Physician

      Volume: 36(1) Pages: 31-35

    • Related Report
      2016 Research-status Report
  • [Journal Article] Standby guardianship 患者の自己決定に基づく親権代行.2016

    • Author(s)
      石川 博康,猪股 良之,神林 崇,清水 徹男
    • Journal Title

      精神医学

      Volume: 58(1) Pages: 87-94

    • NAID

      40020707203

    • Related Report
      2016 Research-status Report
  • [Presentation] オレキシン測定を通して明らかになった症候性ナルコレプシーと 過眠症における臨床的特徴について2018

    • Author(s)
      神林崇
    • Organizer
      日本脳神経外科認知症学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 睡眠障害の神経生物学:動物実験から臨床研究 多発性硬化症、視神経脊髄炎での過眠症2018

    • Author(s)
      神林崇
    • Organizer
      日本睡眠学会定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Symptomatic Narcolepsy with Hypothlamic lesion and Orexin Deficiency2018

    • Author(s)
      Kanbayashi T.
    • Organizer
      2nd Sleep Congress of Asian Society of Sleep Medicine (ASSM 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Diagnosis of Orexin Deficient Symptomatic Narcolepsy (Including Cases Without Hypothlamic Lesion)2018

    • Author(s)
      Kanbayashi T.
    • Organizer
      2nd Sleep Congress of Asian Society of Sleep Medicine (ASSM 2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Symptomatic Narcolepsy with Hypothlamic lesion and Orexin Deficiency2018

    • Author(s)
      神林崇
    • Organizer
      2nd Congress of Asian Society of Sleep Medicine (ASSM 2018)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Neuro-immune diseases in symptomatic narcolepsy.2017

    • Author(s)
      Kanbayashi T
    • Organizer
      Society for neuroscience meeting
    • Place of Presentation
      ソウル
    • Year and Date
      2017-03-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 過眠症の診断と治療における最近の変遷 発達障害併存例の急増とDSM-5の新診断基準2017

    • Author(s)
      神林崇
    • Organizer
      日本睡眠学会2017
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Symptomatic narcolepsy among inherited disorders, such as myotonic dystrophy.2016

    • Author(s)
      Kanbayashi T, Ohmori Y, Imanishi A, et al.
    • Organizer
      Society for neuroscience meeting
    • Place of Presentation
      サンディエゴ
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経ベーチェット病による視床下部病変により髄液オレキシン低値を認めた41歳男性例.2016

    • Author(s)
      藤田 裕明, 鈴木 圭輔, 沼尾 文香, 渡邉 悠児, 永島 隆秀, 高嶋 良太郎, 宮本 雅之, 宮本 智之, 作田 英樹, 神林 崇, 平田 幸一
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Orexin受容体拮抗薬Suvorexantの使用経験(第2報) せん妄も含めて.2016

    • Author(s)
      小野 宏晃,高橋 淳,岩城 忍,今西 彩,佐川 洋平,木村 景,橋本 誠,小野 太輔,神林 崇,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] ナルコレプシーの情動脱力発作とその他のレム関連症状に対する5種の薬剤による治療の検討 最新のベンラファキシンも含めて(第2報).2016

    • Author(s)
      今西 彩,大森 佑貴,小野 太輔,高橋 淳,野澤 成大,小野 宏晃,佐川 洋平,筒井 幸,神林 崇,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 抗Ma2抗体陽性であった症候性ナルコレプシー患者の1例.2016

    • Author(s)
      今西 彩,成田 恵理子,池田 祐介,山辺 拓也,西田 晶子,大森 佑貴,平野 梨聖,倉澤 悠紀,神林 崇,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] マウス睡眠覚醒移行期の非侵襲的心拍呼吸活動記録2016

    • Author(s)
      佐藤 紳一,神林 崇,今西 彩,小野 宏晃,筒井 幸,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 体温と簡易脳波から見た硫黄泉の睡眠への効果.2016

    • Author(s)
      上村 佐知子,梶原 紗希,大貫 周悟,高橋 淳,神林 崇,佐竹 將宏,塩谷 隆信,清水 徹男,西野 精治
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Neuromyelitis optica spectrum disorderの抗MOG抗体とオレキシン値の検討.2016

    • Author(s)
      久保田 弘樹,今西 彩,矢野 珠巨,佐川 洋平,筒井 幸,小野 太輔,野澤 成大,神林 崇,高橋 勉,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 抑うつ症状を伴う睡眠相後退症候群に対するアリピプラゾールの有効性の検討:第2報.2016

    • Author(s)
      大森 佑貴,神林 崇,筒井 幸,高橋 裕哉,佐川 洋平,今西 彩,高橋 淳,小野 太輔,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 過眠症状を伴う筋強直性ジストロフィーにおける脳脊髄液中オレキシン値の検討.2016

    • Author(s)
      大森 佑貴,今西 彩,神林 崇,筒井 幸,高橋 裕哉,佐川 洋平,高橋 淳,小野 太輔,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 無呼吸信号のFFT解析および心周期変動解析による呼吸努力の定量的解析.2016

    • Author(s)
      佐藤 紳一,西島 嗣生,遠藤 文代,神林 崇,山内 基夫,山城 義広,清水 徹男,櫻井 滋
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 睡眠から見たうつ病の病態と治療 うつ病相における過眠症状 夜間睡眠の延長と日中の過度の眠気.2016

    • Author(s)
      神林 崇,今西 彩,鈴木 りほ,池田 祐介,平野 梨聖,竹越 結生,佐々木 諒,藤原 大,佐藤 優真,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 睡眠障害と精神疾患の病態・治療上の接点 過眠症(i:夜間睡眠の延長、ii:日中の眠気)の治療薬.2016

    • Author(s)
      神林 崇,今西 彩,小野 太輔,佐川 洋平,野澤 成大,小野 宏晃,大森 佑貴,高橋 淳,高橋 裕哉,清水 徹男
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
  • [Presentation] A QUANTITATIVE METHOD FOR RESPIRATORY-EFFORT DETECTION BY POWER-SPECTRAL DENSITY ANALYSIS OF ON-MATTRESS PIEZOELECTRIC-SENSOR SIGNAL.2016

    • Author(s)
      Sato S, Nishijima T, Endou F, Kanbayashi T, Yamauchi M, Yamashiro Y, Shimizu T, Sakurai S.
    • Organizer
      The Annual Meeting of the Associated Professional Sleep Societies2016
    • Place of Presentation
      デンバー
    • Year and Date
      2016-06-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] SEVERAL COMPARATIVE TREATMENTS FOR REM RELATED SYMPTOMS AND NOCTURNAL SLEEP DISTURBANCES OF NARCOLEPTIC PATIENT.2016

    • Author(s)
      Imanishi A, Ohmori Y, Suzuki R, Kato N, Sagawa Y, Takahashi Y, Takahashi J, Tsutsui K, Kanbayashi T, Shimizu T.
    • Organizer
      The Annual Meeting of the Associated Professional Sleep Societies2016
    • Place of Presentation
      デンバー
    • Year and Date
      2016-06-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 抗Ma2抗体陽性であった症候性ナルコレプシーの1例2016

    • Author(s)
      成田 恵理子,今西 彩,池田 祐介,川辺 拓也,大森 佑貴,筒井 幸,佐川 洋平,高橋 淳,神林 崇,清水 徹男
    • Organizer
      第112回日本精神神経学会学術総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
  • [Presentation] カタレプシーを呈した急性デキストロメトルファン中毒の一例.2016

    • Author(s)
      高橋 淳,大森 佑貴,竹島 正浩,神林 崇,清水 徹男
    • Organizer
      第112回日本精神神経学会学術総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 睡眠相後退症候群と抑うつ症状の併存例へのアリピプラゾールの有効性.2016

    • Author(s)
      大森 佑貴,神林 崇,筒井 幸,高橋 裕哉,佐川 洋平,今西 彩,高橋 淳,佐藤 優真,佐々木 諒,清水 徹男
    • Organizer
      第112回日本精神神経学会学術総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
  • [Presentation] 精神症状を来す自己免疫性脳症 精神科領域における抗NMDA受容体抗体陽性例.2016

    • Author(s)
      筒井 幸,大森 佑貴,森 朱音,神林 崇,清水 徹男
    • Organizer
      第112回日本精神神経学会学術総会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report
  • [Book] Symptomatic Narcolepsy or Hypersomnolence with and Without Hypocretin (Orexin) Deficiency Narcolepsy, 2nd Edition: A Clinical Guide, Goswami M, edit. Chapter 92016

    • Author(s)
      Kanbayashi T, Imanishi A, Ohmori Y, Sagawa Y, Takahashi Y, Omokawa M, Sato M, Hishikawa Y, Shimizu T, and Nishino S.
    • Publisher
      Springer
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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