Evaluation of the pathogenesis of hypersomnolence and psychosis disorders caused by auto-antibodies
| Project/Area Number |
16K10203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 睡眠覚醒障害 / 抗NMDA受容体脳炎 / orexin / narcolepsy / NMDA encephalitis / AQP4 antibody / GFAP / ナルコレプシー / NMDA受容体脳炎 / 精神生理学 / オレキシン |
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| Outline of Final Research Achievements |
Of the 36 NMO cases, 28 were positive for AQP4 antibody, 8 were negative, and 2 were negative for MOG. Orexin levels were relatively high in MOG positive cases. In both cases where both antibodies were negative, improvement in orexin levels after treatment was poor.
NMDAR antibody was positive in 14 out of 169 cases. Seven of the 14 cases had encephalitis and were initially diagnosed with tension disease. The other 7 cases were cases of only mental symptoms without neurological symptoms, and psychiatric diagnosis was 3 cases of tension disorders, 2 cases of short-term mental disorders and 2 cases of schizophrenia. In 25 sleep disorders, 6 positive cases were found. 5 were narcolepsy and 1 was recurrent hypersomnia in these 6 positive cases.
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| Academic Significance and Societal Importance of the Research Achievements |
オレキシン神経障害を来して、過眠症状を示すNMO36症例のうちで、AQP4抗体陽性例は28例と大部分を占めている。NMOの国際診断基準の中核症状の1つにも過眠症状があげられており、頻度が高いことは妥当な結果と思われる。NMDAR抗体が精神症状のみの7例で陽性であったことは特筆すべきことであり、統合失調症と考えられていた症例のうちで、僅かではあるが神経抗体により症状が発現している症例が存在することになる。睡眠障害に精神症状を呈した症例でも陽性例があり、抗体による精神症状の発現は希有な物ではないと考えられる。
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Cerebrospinal fluid orexin-A levels in systemic lupus erythematosus patients presenting with excessive daytime sleepiness.2018
Author(s)
Suzuki K, Miyamoto M, Miyamoto T, Matsubara T, Inoue Y, Iijima M, Mizuno S, Horie J, Hirata K, Shimizu T, Kanbayashi T.
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Journal Title
Lupus.
Volume: 11
Issue: 11
Pages: 1847-1853
DOI
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Peer Reviewed
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[Journal Article] Clinical Experience with a Dual Orexin Receptor Antagonist, Suvorexant (Belsomra) in Japan.2018
Author(s)
Ono H, Kanbayashi T, Iwaki S, Takahashi J, Imanishi A, Sagawa Y, Tsutsui K, Omori Y, Nishino S, Shimizu T.
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Journal Title
J Sleep Disord Med Care
Volume: 1(1)
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Peer Reviewed
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[Journal Article] Cerebrospinal fluid orexin-A levels in systemic lupus erythaematosus patients presenting with excessive daytime sleepiness2018
Author(s)
Suzuki K, Miyamoto M, Miyamoto T, Matsubara T, Inoue Y, Iijima M, Mizuno S, Horie J, Hirata K, Shimizu T, Kanbayashi T.
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Peer Reviewed
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[Journal Article] 精神症状を呈した再発性多発軟骨炎の1例．2016
Author(s)
大森 佑貴, 草薙 宏明, 筒井 幸, 高橋 淳, 安宅 慶一郎, 奈良 瑞穂, 利川 嘉明, 大谷 隆浩, 高橋 聡, 齋藤 英知, 神林 崇, 清水 徹男
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Journal Title
精神科治療学
Volume: 31(2)
Pages: 247-253
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Peer Reviewed
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[Presentation] 神経ベーチェット病による視床下部病変により髄液オレキシン低値を認めた41歳男性例．2016
Author(s)
藤田 裕明, 鈴木 圭輔, 沼尾 文香, 渡邉 悠児, 永島 隆秀, 高嶋 良太郎, 宮本 雅之, 宮本 智之, 作田 英樹, 神林 崇, 平田 幸一
Organizer
日本睡眠学会第41回定期学術集会
Place of Presentation
京王プラザホテル
Year and Date
2016-07-07
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[Book] Symptomatic Narcolepsy or Hypersomnolence with and Without Hypocretin (Orexin) Deficiency Narcolepsy, 2nd Edition: A Clinical Guide, Goswami M, edit. Chapter 92016
Author(s)
Kanbayashi T, Imanishi A, Ohmori Y, Sagawa Y, Takahashi Y, Omokawa M, Sato M, Hishikawa Y, Shimizu T, and Nishino S.
Publisher
Springer
Related Report
