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Neural correlates of the oxytocin in the treatment of autism spectrum disorder based on aberrant neural network hypothesis

Research Project

Project/Area Number 16K10206
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionUniversity of Fukui

Principal Investigator

Takahashi Tetsuya  福井大学, 学術研究院医学系部門, 客員准教授 (00377459)

Co-Investigator(Kenkyū-buntansha) 菊知 充  金沢大学, 子どものこころの発達研究センター, 教授 (00377384)
平石 博敏  浜松医科大学, 光尖端医学教育研究センター, 特任研究員 (40643789)
山西 輝也  福井工業大学, 環境情報学部, 教授 (50298387)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords自閉症スぺクトラム障害 / 神経ネットワーク / GABA神経活動 / 脳磁図 / オキシトシン / ネットワーク解析 / 自閉症スペクトラム障害 / 神経ネットワーク解析 / 自閉性スペクトラム障害 / GABA神経 / 自閉性障害 / 非線形・グラフ解析
Outline of Final Research Achievements

GABAergic dysfunction plays a crucial role in the pathogenesis of aberrant neural network hypothesis in autism spectrum disorder (ASD). The perinatal excitatory-to-inhibitory shift of GABA is mediated by oxytocin. The deficit of this oxytocin-mediated GABA inhibition reportedly associates with the prevalence of ASD. Therefore, oxytocin has been receiving great attention as a neuroprotective agent of ASD.
Gamma-band oscillatory activity is reportedly involved in mediating GABAergic activity. Additionally, complex network theory is a useful approach in understanding brain network. This research aimed to elucidate therapeutic mechanisms of oxytocin in ASD using MEG with newly developed analysis methods.

Academic Significance and Societal Importance of the Research Achievements

本研究課題で開発した、dynamical phase synchronization analysis(Nobukawa et al., 2018)は動的な位相同期現象を複雑性理論によって定量化するものであり、またtemporal-scale-specific fractal analysis(Nobukawa et al., 2019)は複数の時間軸を用いて、時系列上の複雑性を定量化するものである。
これらの解析法は、神経ネットワーク特性に新たな視点をもたらす先駆的な解析法であり、今後精神疾患における神経ネットワーク異常を理解する上で重要な役割を果たすと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Changes in functional connectivity dynamics with aging: A dynamical phase synchronization approach2019

    • Author(s)
      Sou Nobukawa, Mitsuru Kikuchi, Tetsuya Takahashi
    • Journal Title

      NeuroImage

      Volume: 188 Pages: 357-368

    • DOI

      10.1016/j.neuroimage.2018.12.008

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atypical temporal-scale-specific fractal changes in Alzheimer's disease EEG and their relevance to cognitive decline2019

    • Author(s)
      Sou Nobukawa, Teruya Yamanishi, Haruhiko Nishimura, Yuji Wada, Mitsuru Kikuchi, Tetsuya Takahashi
    • Journal Title

      Cognitive Neurodynamics

      Volume: 13 Issue: 1 Pages: 1-11

    • DOI

      10.1007/s11571-018-9509-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abnormal functional connectivity of high-frequency rhythms in drug-naïve schizophrenia.2018

    • Author(s)
      Takahashi T, Goto T, Nobukawa S, Tanaka Y, Kikuchi M, Higashima M, Wada Y.
    • Journal Title

      Clin Neurophysiol.

      Volume: 129 Issue: 1 Pages: 222-231

    • DOI

      10.1016/j.clinph.2017.11.004

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Band-specific atypical functional connectivity pattern in childhood autism spectrum disorder.2017

    • Author(s)
      Takahashi T, Yamanishi T, Nobukawa S, Kasakawa S, Yoshimura Y, Hiraishi H, Hasegawa C, Ikeda T, Hirosawa T, Munesue T, Higashida H, Minabe Y, Kikuchi M.
    • Journal Title

      Clin Neurophysiol.

      Volume: 128 Issue: 8 Pages: 45-50

    • DOI

      10.1016/j.clinph.2017.05.010

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Band-specific atypical functional connectivity pattern in childhood autism spectrum disorder2017

    • Author(s)
      Tetsuya Takahashi, Teruya Yamanishi, Sou Nobukawa, Shinya Kasakawa, Yuko Yoshimura, Hirotoshi Hiraishi, Chiaki Hasegawa, Takashi Ikeda, Tetsu Hirosawa, Toshio Munesue, Haruhiro Higashida, Yoshio Minabe, Mitsuru Kikuchi
    • Journal Title

      Clinical Neurophysiology

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] How to characterize complex brain networks2019

    • Author(s)
      Tetsuya Takahashi
    • Organizer
      Mechanism of Brain and Mind 19th Winter Workshop
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Childhood Brain Signal Complexity and Connectivity2018

    • Author(s)
      T Takahashi, T Ikeda, C Hasegawa, Y Yoshimura, Nobukawa, Y Minabe, M Kikuchi
    • Organizer
      The 21st International Conference on Biomagnetism
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 神経ネットワークダイナミクスから探る精神疾患のメカニズム2017

    • Author(s)
      高橋哲也
    • Organizer
      第17回Kフォーラム
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Increasing Signal Variability During Development and Its Relevance to Autism Spectrum Disorders2017

    • Author(s)
      Tetsuya Takahashi
    • Organizer
      World Federation of Societies of Biological Psychiatry
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Emerging Field of E/MEG Analyses on Neural Network-Complexity and Connectivity-2017

    • Author(s)
      Tetsuya Takahashi
    • Organizer
      Germany-Hong Kong Joint Workshop at the Hong Kong Baptist University
    • Related Report
      2017 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 生体信号処理装置、生体信号処理システム、および制御プログラム2017

    • Inventor(s)
      高橋哲也
    • Industrial Property Rights Holder
      高橋哲也
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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