An alpha7 nicotinic acetylcholine receptor in anorexia nervosa

• Project/Area Number: 16K10210
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Yokokura Masamichi 浜松医科大学, 医学部, 助教 (00529399)
• Co-Investigator(Kenkyū-buntansha): 間賀田 泰寛 浜松医科大学, 光尖端医学教育研究センター, 教授 (20209399) ; 尾内 康臣 浜松医科大学, 光尖端医学教育研究センター, 教授 (40436978) ; 和久田 智靖 浜松医科大学, 医学部附属病院, 講師 (80444355)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 神経性やせ症 / PET / α7ニコチン性アセチルコリン受容体 / 神経科学 / 精神科 / 神経性無食欲症

Outline of Final Research Achievements

Anorexia nervosa (AN) is a psychiatric disorder characterized by significantly low body weight, leading the high mortality rate. Cognitive impairments were reported to be associated with severity of AN. Recently, we can measure the in vivo alpha 7 nicotinic acetylcholine receptor (a7-nAChR), which is associated with cognitive function, using positron emission tomography (PET). Here, we aimed to investigate alterations of the a7-nAChR in patients with AN.
We recruited 19 healthy subjects (5 males and 14 females) in order to confirm the protocol of PET measurement. We selected 14 healthy female subjects from those healthy group. We recruited female patients with AN to compare those female healthy group. Female patients with AN could not underwent the PET measurement due to mechanical trouble.

Academic Significance and Societal Importance of the Research Achievements

神経性無食欲症(Anorexia Nervosa: AN)は低体重で死の危険が高い精神障害で、認知機能障害が症状と関連していると考えられている。本研究では健常者19名(男性5名、女性14名)をリクルートし、Positron Emission Tomographyを用いて、脳内で認知機能と関連するα7-nAChRの計測法を確立できた。その上で女性AN患者の撮像を試みたが、機械の不具合からAN患者の撮像には至れなかった。しかし上記の健常群において女性14名の撮像が終了しているので、今後は外部研究費を獲得してAN患者のリクルートを進めていきたい

Research Products

• [Journal Article] Depiction of microglial activation in aging and dementia: Positron emission tomography with [11C]DPA713 versus [11C](R)PK11195. (2016)
  • Author(s): Yokokura M, Terada T, Bunai T, Nakaizumi K, Takebayashi K, Iwata Y, Yoshikawa E, Futatsubashi M, Suzuki K, Mori N, Ouchi Y.
  • Journal Title: J Cereb Blood Flow Metab. Volume: 37 Issue: 3 Pages: 877-889
  • DOI: 10.1177/0271678x16646788
  • Peer Reviewed
• [Presentation] [11C](R)MeQAA PETによる統合失調症患者におけるα7ニコチン性アセチルコリン受容体の検討 (2018)
  • Author(s): 横倉 正倫、和久田 智靖、中泉 享子、加藤 康彦、亀野 陽亮、寺田 達弘、武内 智康、吉川 悦次、間賀田 泰寛、尾内 康臣、武井 教史、山末 英典
  • Organizer: 第41回日本神経科学大会
• [Presentation] Activated microglia increased in anorexia nervosa: a [11C]DPA713 PET study (2018)
  • Author(s): Yokokura M, Terada T, Bunai T, Nakaizumi K, Yasuhiko Kato, Futatsubashi M, Yoshikawa E, Yamasue H, Ouchi Y
  • Organizer: The 17th conference of peace through mind/brain science
  • Int'l Joint Research
• [Presentation] Activated microglia in attention-deficit/hyperactivity disorder: a positron emission tomography study (2018)
  • Author(s): Yokokura M, Yamasue H, Ouchi Y
  • Organizer: The world federation of society of biological psychiatry (WFSBP) 2018 KOBE
  • Int'l Joint Research
• [Presentation] Activated microglia increased in anorexia nervosa: a [11C]DPA713 PET study (2018)
  • Author(s): Yokokura M, Terada T, Bunai T, Nakaizumi K, Yasuhiko Kato, Futatsubashi M, Yoshikawa E, Ouchi Y
  • Organizer: The 17th conference of peace through mind/brain science
  • Int'l Joint Research
• [Presentation] 神経性やせ症におけるセロトニントランスポーターの検討：[11C]DASB PET study. (2017)
  • Author(s): 横倉 正倫、寺田 達弘、武内 智康、中泉 享子、二ツ橋 昌実、吉川 悦次、尾内 康臣
  • Organizer: 第113回日本精神神経学会学術総会
• [Presentation] Increased microglial activation in anorexia nervosa: a [11C]DPA713 PET study (2017)
  • Author(s): Yokokura M, Terada T, Bunai T, Nakaizumi K, Yasuhiko Kato, Futatsubashi M, Yoshikawa E, Ouchi Y
  • Organizer: Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Reduced serotonin transporter availability in anorexia nervosa: a [11C]DASB PET study (2016)
  • Author(s): 7．Yokokura M, Terada T, Bunai T, Nakaizumi K, Takebayashi K, Futatsubashi M, Yoshikawa E, Ouchi Y
  • Organizer: Neuroscience 2016
  • Place of Presentation: san diego
  • Year and Date: 2016-11-12
  • Int'l Joint Research