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Effects of return-to-work program on autonomic nervous system activity in workers on sick leave due to depression

Research Project

Project/Area Number 16K10254
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionYokohama City University

Principal Investigator

KISHIDA Ikuko  横浜市立大学, 医学研究科, 客員講師 (60464533)

Co-Investigator(Kenkyū-buntansha) 藤林 真美  摂南大学, スポーツ振興センター, 准教授 (40599396)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords気分障害 / リワークプログラム / 自律神経活動 / 統合失調症 / 抗精神病薬 / 薬理遺伝学 / 自律神経活動動態 / 心拍変動パワースペクトル解析 / 精神科リハビリテーション学
Outline of Final Research Achievements

Return-to-work (RTW) program have been executed in recent years. But the biological effect of RTW program is not clear yet. We evaluated the effect of RTW program on autonomic nervous system (ANS) activities and psychiatric symptoms of the workers on sick leave due to mental disorders. This study involves 104 Japanese workers on sick leave due to major depression or bipolar disorder. All of the participants received RTW program for 3 months in Yokohama City University Hospital. The ANS activity of participants was evaluated using heart rate variability at the beginning and ending of 3 months program. Psychiatric symptoms were evaluated by MADRS-J and SASS. Parasympathetic activity at the ending was significantly higher than that at the beginning (p=0.014). Psychiatric symptoms were significantly improved at the ending (p<0.001). This study revealed that RTW program is effective for improving both parasympathetic activity and psychiatric symptoms.

Academic Significance and Societal Importance of the Research Achievements

近年、長期休職者に占めるメンタル不全者の割合が増大しており、職域におけるリワーク対策が急務となっている。現在までにリワークプログラムを実施する医療機関が全国的に広がっているが、その効果を科学的に探索した研究は十分ではない。本研究では、気分障害患者を対象にしたリワークプログラムにより、疾患重症度のみならず、自律神経活動が有意に改善することが明らかになり、リワークプログラムの有効性を科学的に検証することができた。今後も、リワークプログラムを含めた精神科リハビリを施行することで、気分障害による長期休職者の復職率上昇の一助となることが期待できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2020 2019 2018 2017 2016

All Journal Article (8 results) (of which Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] The association of genetic polymorphisms in CYP1A2, UGT1A4, and ABCB1 with autonomic nervous system dysfunction in schizophrenia patients treated with olanzapine2020

    • Author(s)
      Hattori Saki、Suda Akira、Miyauchi Masatoshi、Shiraishi Yohko、Saeki Takashi、Fukushima Tadashi、Fujibayashi Mami、Tsujita Natsuki、Ishii Chie、Ishii Norio、Moritani Tosiho、Saigusa Yusuke、Kishida Ikuko
    • Journal Title

      BMC Psychiatry

      Volume: 20 Issue: 1 Pages: 72-72

    • DOI

      10.1186/s12888-020-02492-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A return to work program improves parasympathetic activity and psychiatric symptoms in workers on sick leave due to depression2019

    • Author(s)
      Hattori S, Kishida I, Suda, A, Kawanishi C, Miyauchi M, Shiraishi Y, Fujibayashi M, Trsujita N, Ishii C, Moritani T, Saigusa Y, Hirayasu Y
    • Journal Title

      Heliyon

      Volume: 5 Issue: 7 Pages: e02151-e02151

    • DOI

      10.1016/j.heliyon.2019.e02151

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of ABCB1 gene polymorphisms on autonomic nervous system activity during atypical antipsychotic treatment in schizophrenia2018

    • Author(s)
      Hattori Saki、Suda Akira、Kishida Ikuko、Miyauchi Masatoshi、Shiraishi Yohko、Fujibayashi Mami、Tsujita Natsuki、Ishii Chie、Ishii Norio、Moritani Toshio、Taguri Masataka、Hirayasu Yoshio
    • Journal Title

      BMC Psychiatry

      Volume: 18 Issue: 1 Pages: 231-231

    • DOI

      10.1186/s12888-018-1817-5

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between dysfunction of autonomic nervous system activity and mortality in schizophrenia2018

    • Author(s)
      Hattori Saki、Suda Akira、Kishida Ikuko、Miyauchi Masatoshi、Shiraishi Yohko、Fujibayashi Mami、Tsujita Natsuki、Ishii Chie、Ishii Norio、Moritani Toshio、Saigusa Yusuke、Hirayasu Yoshio
    • Journal Title

      Comprehensive Psychiatry

      Volume: 86 Pages: 119-122

    • DOI

      10.1016/j.comppsych.2018.08.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of long-acting injectable antipsychotics versus oral antipsychotics on autonomic nervous system activity in schizophrenic patients2018

    • Author(s)
      Suda Akira、Hattori Saki、Kishida Ikuko、Miyauchi Masatoshi、Shiraishi Yohko、Fujibayashi Mami、Tsujita Natsuki、Ishii Chie、Ishii Norio、Moritani Toshio、Hirayasu Yoshio
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: Volume 14 Pages: 2361-2366

    • DOI

      10.2147/ndt.s173617

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of four atypical antipsychotics on autonomic nervous system activity in schizophrenia2018

    • Author(s)
      Hattori Saki、Kishida Ikuko、Suda Akira、Miyauchi Masatoshi、Shiraishi Yohko、Fujibayashi Mami、Tsujita Natsuki、Ishii Chie、Ishii Norio、Moritani Toshio、Taguri Masataka、Hirayasu Yoshio
    • Journal Title

      Schizophrenia Research

      Volume: 193 Pages: 134-138

    • DOI

      10.1016/j.schres.2017.07.004

    • NAID

      130007901367

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations of ABCB1 gene polymorphisms with aripiprazole-induced autonomic nervous system dysfunction in schizophrenia2017

    • Author(s)
      Hattori Saki、Suda Akira、Kishida Ikuko、Miyauchi Masatoshi、Shiraishi Yohko、Fujibayashi Mami、Tsujita Natsuki、Ishii Chie、Ishii Norio、Moritani Toshio、Taguri Masataka、Hirayasu Yoshio
    • Journal Title

      Schizophrenia Research

      Volume: - Pages: 16-18

    • DOI

      10.1016/j.schres.2017.11.020

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 統合失調症患者のサルコペニア(筋量減少)の発生と座位中心の生活習慣との関連についての調査2017

    • Author(s)
      石井千惠, 岸田郁子, 茅沼弓子, 宮内雅利, 藤林真美, 武内玲, 柴田昌志, 森谷敏夫, 石井紀夫
    • Journal Title

      日本精神科神経科診療所協会ジャーナル

      Volume: 43 Pages: 4-9

    • Related Report
      2017 Research-status Report
  • [Presentation] リワークプログラム通所中の気分障害患者における自律神経活動動態調査2019

    • Author(s)
      岸田郁子, 服部早紀, 須田顕, 宮内雅利, 白石洋子, 石井千惠, 石井紀夫, 平安良雄
    • Organizer
      第115回日本精神神経学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Long term effects of smoking cessation in hospitalized schizophrenia patients2019

    • Author(s)
      Miyauchi M, Suda A, Hattori S, Shiraishi Y, Ishii C, Fujibayashi M, Moritani M, Kishida I
    • Organizer
      14th World Congress of Biological Psychiatry
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高齢の統合失調症患者の自律神経活動低下と生命予後の関連性について2019

    • Author(s)
      服部早紀, 須田顕, 岸田郁子, 宮内雅利, 白石洋子, 藤林真美, 辻田那月, 石井千恵, 平川和重, 俵美河, 福島瑞, 佐伯隆史, 森谷敏夫, 平安良雄
    • Organizer
      第 14 回日本統合失調症学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of four atypical antipsychotics on autonomic nervous system activity in schizophrenia2018

    • Author(s)
      Hattori S, Suda A, Kishida I, Miyauchi M, Shiraishi Y, Fujibayashi M, Tsujita N, Ishii C, Ishii N, Moritani T, Hirayasu Y
    • Organizer
      The 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] リワークにおける運動療法による状態不安の変化について2018

    • Author(s)
      茅沼弓子, 岸田郁子, 石井千恵, 藤林真実, 石井紀夫
    • Organizer
      第16回日本スポーツ精神医学会総会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] リワークプログラムが大うつ病性障害・双極性障害の患者の自律神経活動へもたらす影響について2018

    • Author(s)
      服部早紀, 須田顕, 岸田郁子, 宮内雅利, 白石洋子, 藤林真美, 辻田那月, 石井千恵, 石井 紀夫, 森谷敏夫, 平安良雄
    • Organizer
      第40回日本生物学的精神医学会・第61回日本神経化学会大会 合同年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 自律神経を知ろう!2018

    • Author(s)
      岸田郁子
    • Organizer
      第3回臨床自律神経機能Forum
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] リワークプログラム通所中の患者における自律神経活動動態調査2017

    • Author(s)
      服部早紀,須田顕,岸田郁子,宮内雅利,白石洋子, 藤林真美, 辻田那月, 石井千恵,石井紀夫,森谷敏夫,平安良雄
    • Organizer
      第39回 日本生物学的精神医学会・第47回 日本神経精神薬理学会 合同年会
    • Related Report
      2017 Research-status Report
  • [Presentation] 統合失調症患者の自律神経活動におけるCYP2D6遺伝子,ABCB1遺伝子の遺伝子多型の関与について2017

    • Author(s)
      服部早紀,須田顕, 岸田郁子,宮内雅利,白石洋子, 藤林真美, 辻田那月, 石井千恵,石井紀夫,森谷敏夫,平安良雄
    • Organizer
      第27回日本臨床精神神経薬理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] リワークプログラム通所中の気分障害患者における自律神経活動動態調査2016

    • Author(s)
      服部早紀, 岸田郁子, 藤林真美, 須田顕, 宮内雅利,石井千恵, 石井紀夫, 森谷敏夫, 平安良雄
    • Organizer
      第38回日本生物学的精神医学会
    • Place of Presentation
      福岡国際会議場 (福岡県福岡市)
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
  • [Book] 精神科レジデントハンドブック2017

    • Author(s)
      平安 良雄、横浜市立大学医学部精神医学教室
    • Total Pages
      310
    • Publisher
      中外医学社
    • ISBN
      9784498229006
    • Related Report
      2017 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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