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Development of imaging bio-markers and prognosis prediction systems for cancer treatment using multi-layer CT

Research Project

Project/Area Number 16K10287
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKumamoto University

Principal Investigator

Nakaura Takeshi  熊本大学, 大学院生命科学研究部(医), 特任講師 (90437913)

Co-Investigator(Kenkyū-buntansha) 船間 芳憲  熊本大学, 大学院生命科学研究部(保), 教授 (30380992)
宇都宮 大輔  横浜市立大学, 医学研究科, 教授 (30571046)
木藤 雅文  熊本大学, 大学院生命科学研究部(医), 特任助教 (40744909)
平田 健一郎  熊本大学, 医学部附属病院, 非常勤診療医師 (60759562)
尾田 済太郎  熊本大学, 大学院生命科学研究部(医), 特任助教 (80571041)
幸 秀明  熊本大学, 医学部附属病院, 非常勤診療医師 (90710434)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
KeywordsDual Energy CT / 機械学習 / Texture解析 / Radiomics / エックス線・CT / がん治療効果判定
Outline of Final Research Achievements

Multi-layer detector CT was able to acquire iodine density and electron density images etc. in comparison with conventional CT, and could obtain a lot of useful information for the tumors. These basic reviews are published in leading journals such as European Radiology and European Journal of Radiology.
When applied to the differentiation of lung cancer based on these data, results superior to those of conventional CT are obtained, and it seems to be promising as an imaging biomarker. These were presented at home and abroad conferences. Prognostic evaluation for early lung cancer is still being collected for a very low recurrence rate.

Academic Significance and Societal Importance of the Research Achievements

多層検出器CTは日常臨床に導入されて日が浅く、その基本的な性能は広く認知されていなかったが、我々の検討で様々な領域に有用であることが証明された。また、機械学習の元データとしても有用性が高く、画像バイオマーカーとして有望なことについても解明できた。しかし、近年の早期癌の再発率の低下もあり、癌治療後の予後についてまでは研究期間内では証明する事ができなかった。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2018 2017

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Journal Article] Dual-layer DECT for multiphasic hepatic CT with 50 percent iodine load: a matched-pair comparison with a 120 kVp protocol.2018

    • Author(s)
      Nagayama Y, Nakaura T, Oda S, Utsunomiya D, Funama Y, Iyama Y, Taguchi N, Namimoto T, Yuki H, Kidoh M, Hirata K, Nakagawa M, Yamashita Y.
    • Journal Title

      European Radiology

      Volume: 28 Issue: 4 Pages: 1719-1730

    • DOI

      10.1007/s00330-017-5114-3

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual-layer dual-energy computed tomography for the assessment of hypovascular hepatic metastases: impact of closing k-edge on image quality and lesion detectability2018

    • Author(s)
      Nagayama Yasunori、Iyama Ayumi、Oda Seitaro、Taguchi Narumi、Nakaura Takeshi、Utsunomiya Daisuke、Kikuchi Yoko、Yamashita Yasuyuki
    • Journal Title

      European Radiology

      Volume: 印刷中 Issue: 6 Pages: 2837-2847

    • DOI

      10.1007/s00330-018-5789-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual-Layer Computed Tomography in Cardiovascular Imaging2018

    • Author(s)
      Nakaura T, Oda S,Utsunomiya D, Tokuyasu S,2 and Yasuyuki Yamashita1
    • Journal Title

      Cardiovasc Imaging Asia

      Volume: Apr;2(2) Issue: 2 Pages: 49-57

    • DOI

      10.22468/cvia.2018.00066

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Presentation] CT texture analysis to distinguish moderate/poor- and well differentiate adenocarcinoma of the lung: Usefulness of machine learning based on spectral CT imaging2018

    • Author(s)
      中浦猛
    • Organizer
      第77回放射線学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Dual/spectral CT: an overview of the current status for use in body imaging2018

    • Author(s)
      中浦猛
    • Organizer
      55th radiation society of Thailand meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CT texture analysis to distinguish moderate/poor- and well differentiate adenocarcinoma of the lung: Usefulness of machine learning based on spectral CT imaging2018

    • Author(s)
      中浦 猛
    • Organizer
      第77回放射線学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 日常臨床における iQon Spectral CTの有用性: 低電圧CTと比較して2017

    • Author(s)
      中浦 猛
    • Organizer
      第76回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2017-04-13
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Texture analysis / machine learning in evaluation of lung lesion2017

    • Author(s)
      中浦 猛
    • Organizer
      13th MDCT user meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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