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Detection of cerebral microvascular lesions using 7T MRI in patients with Neuro-Behcet disease

Research Project

Project/Area Number 16K10292
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionIwate Medical University

Principal Investigator

SASAKI NOBUHITO  岩手医科大学, 医学部, 講師 (50382601)

Co-Investigator(Kenkyū-buntansha) 水野 昌宣  岩手医科大学, 医学部, 特任講師 (70382603)
佐々木 真理  岩手医科大学, 医歯薬総合研究所, 教授 (80205864)
及川 侑芳  岩手医科大学, 医学部, 任期付助教 (40781563)
中村 豊  岩手医科大学, 医学部, 准教授 (60328614)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords神経ベーチェット病 / 微小血管病変 / 慢性神経ベーチェット病 / 脳微小血管病変 / ベーチェット病 / 中枢神経ベーチェット / 神経Behcet病 / 7TeslaMRI / 脳血管炎 / 放射線診断
Outline of Final Research Achievements

We prospectively examined 12 patients with Behcet disease (BD), including four with Neuro-Behcet disease (NBD), using a 7 T MRI scanner. High-resolution twodimensional T2-weighted images and high-resolution threedimensional T1-weighted images (T1WIs) before and after the administration of contrast agents were obtained. On the high-resolution T1WIs obtained at 7T,minutepunctate/linear hyperintense lesions in subcortical and/or cortical areas were found in three (75%) NBD patients and one (12.5%) BD patient. Further, the minute punctate enhanced lesions in these areas were found on contrastenhanced T1WIs in 2(50%) NBD patients. These findings suggesting microvascular thrombi or inflammation were significantly more frequent in NBD than in BD patients. High-resolution T1WIs obtained at 7 T can detect minute lesions, indicating intracerebral microvascular lesions in patients. Further studies are needed in order to increase the number of case series.

Academic Significance and Societal Importance of the Research Achievements

希少疾患である神経BDについて7TeslaMRIで撮像した。 微小血管病変を検出できた。同病変は髄質動静脈の分布に一致しておりBD症例では認められない所見であったことから神経BDの特異的な所見である可能性がある。新しい知見をを示された。但し症例数が少なく今後の研究課題である。慢性神経BDのこれまで報告と同様に髄液中サイトカイン高値を認めまた小脳萎縮を認めた。慢性型初期病変については今後の検討課題として残された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (7 results)

All 2019 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Detecting lenticulostriate artery lesions in patients with acute ischemic stroke using high-resolution MRA at 7T.2019

    • Author(s)
      Miyazawa H, Natori T, Kameda H, Sasaki M, Ohba H, Narumi S, Ito K, Sato M, Suzuki T, Tsuda K, Yoshioka K, Terayama Y
    • Journal Title

      International Journal of Stroke

      Volume: 14 Issue: 3 Pages: 290-297

    • DOI

      10.1177/1747493018806163

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Lenticulostriate Arteries Changes by 7 T Magnetic Resonance Angiography in Type 2 Diabetes2018

    • Author(s)
      Yashiro Satoshi、Kameda Hiroyuki、Chida Ai、Todate Yusuke、Hasegawa Yutaka、Nagasawa Kan、Uwano Ikuko、Sasaki Makoto、Ogasawara Kuniaki、Ishigaki Yasushi
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 25 Issue: 10 Pages: 1067-1075

    • DOI

      10.5551/jat.43869

    • NAID

      130007494189

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2018-10-01
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of the genetic variants of GLCCI1 on clinical features of asthmatic patients.2018

    • Author(s)
      Chiba S, Nakamura Y, Mizuno T, Abe K, Horii Y, Nagashima H, Sasaki N, Kanno H, Tanita T, Yamauchi K.
    • Journal Title

      The Clinical Respiratory Journal

      Volume: 12 Issue: 3 Pages: 1166-1173

    • DOI

      10.1111/crj.12647

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preoperative Cerebral Oxygen Extraction Fraction Imaging Generated from 7T MR Quantitative Susceptibility Mapping Predicts Development of Cerebral Hyperperfusion following Carotid Endarterectomy.2017

    • Author(s)
      Nomura JI, Uwano I, Sasaki M, Kudo K, Yamashita F, Ito K, Fujiwara S, Kobayashi M, Ogasawara K.
    • Journal Title

      AJNR Am J Neuroradiol.

      Volume: 38(12) Issue: 12 Pages: 499-505

    • DOI

      10.3174/ajnr.a5390

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A phosphatidylinositol 3-kinase inhibitor strongly suppressed pulmonary vascular remodeling of allergic vasculitis in a murine model2016

    • Author(s)
      Oikawa Y, Sasaki N, Niisato M, Nakamura Y, Yamauchi K
    • Journal Title

      Exp Lung Res

      Volume: 17 Issue: 3 Pages: 1-10

    • DOI

      10.3109/01902148.2016.1157226

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Incidence and Baseline Characteristics of Exacerbation in Patients with Interstitial Pneumonia with Autoimmune Features: A Single Center Large-Scale Cross-Sectional Cohort Study2018

    • Author(s)
      Okinori Murata, Nobuhito Sasaki and Makoto Maemondo
    • Organizer
      2018 ACR/ARHP Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Rapamycin strongly suppressed Pulmonary Vascular Remodeling in a Murine Model of Allergic Vasculitis2017

    • Author(s)
      Nobuhito Sasaki
    • Organizer
      The 18th International Vasculitis and ANCA Workshop
    • Place of Presentation
      Tokyo
    • Year and Date
      2017-03-25
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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