MR Visualization of Treatment Margins Surrounding Liver Cancer in Radiotherapy

• Project/Area Number: 16K10332
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Cancer Center Japan
• Principal Investigator: Yamaguchi Masayuki 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 (90450577)
• Research Collaborator: Furuta Toshihiro ; Ohnuki Kazunobu
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 核磁気共鳴画像（MRI） / 肝がん / 放射線治療 / 画像診断 / 造影剤 / 核磁気共鳴画像（ＭＲＩ） / 核磁気共鳴画像（MRI) / 癌 / 放射線

Outline of Final Research Achievements

We invented an MRI technique that can clearly visualize liver cancers and surrounding liver tissues in the early period after radiotherapy had started. We utilized clinically-approved iron oxide-based contrast media. This technique may reduce the risk of local recurrence of cancer lesions as well as the risk of radiation-induced liver damage when using with image-guided radiotherapy. In this project, we investigated the mechanism of the visualization from cell-biological point-of-view and also performed preclinical experiments using an ultra-high field MRI system to show the feasibility of the technique in vivo.

Academic Significance and Societal Importance of the Research Achievements

放射線照射によって、本来細胞が持つ、酸化鉄を分解し排泄する機能に異常が生じることを初めて明らかにし、その分解や排泄の速度を調べる手法を考案した点で学術的な意義が大きい。肝がんの放射線治療成績の向上につながる知見が得られた点は、将来の患者利益につながる。また、酸化鉄製剤の新しい使用法を見出した点で、将来、関連領域の創薬につながる可能性もあり、社会的にも意義がある研究と考えられる。

Research Products

• [Journal Article] MR Visualization of Macrophages’ Damage in Response to X-Irradiation by Detecting Intracellular SPIO Deposition (2019)
  • Author(s): Masayuki Yamaguchi, Kazunobu Ohnuki, Kenji Hotta, Hirofumi Fujii
  • Journal Title: Proc. Intl. Soc. Mag. Reson. Med. Volume: 27 Pages: 4651-4651
  • Peer Reviewed
• [Journal Article] MR Signal Changes in Superparamagnetic Iron Oxide Nanoparticle-Labeled Macrophages in Response to X-Irradiation (2019)
  • Author(s): Masayuki Yamaguchi, Kazunobu Ohnuki, Kenji Hotta, Hirofumi Fujii
  • Journal Title: NMR in Biomedicine Volume: 印刷中
  • Peer Reviewed
• [Presentation] A Novel MRI Technique for the Visualization of Macrophage's Response to X-irradiation (2019)
  • Author(s): Masayuki Yamaguchi, Kazunobu Ohnuki, Kenji Hotta, Hirofumi Fujii
  • Organizer: 第78回日本医学放射線学会総会
• [Presentation] MR Visualization of Macrophages’ Damage in Response to X-Irradiation by Detecting Intracellular SPIO Deposition (2019)
  • Author(s): Masayuki Yamaguchi, Kazunobu Ohnuki, Kenji Hotta, Hirofumi Fujii
  • Organizer: ISMRM 27th Annual Meeting & Exhibition
  • Int'l Joint Research
• [Presentation] SPIONs標識マクロファージのX線照射に対する反応とMRI信号変化 (2018)
  • Author(s): 山口雅之
  • Organizer: 第22回NMRマイクロイメージング研究会
  • Invited
• [Presentation] 新たなクッパー細胞MRイメージング手法による 放射線肝障害領域の描出：ラット肝腫瘍モデルによる実験的検討 (2017)
  • Author(s): 古田寿宏、山口雅之、南 学、阿部修、藤井博史
  • Organizer: 第12回日本分子イメージング学会
  • Place of Presentation: 横浜港大さん橋ホール（神奈川県・横浜市）
  • Year and Date: 2017-05-25
• [Presentation] A new technique of SPIO-enhanced MRI: delayed recovery of T2*-weighted sugnai intensity as a novel diagnostic marker for visualization of irradiated liver parenchyma. (2017)
  • Author(s): Furuta T, Yamaguchi M, Minami M, Abe O, Fujii H
  • Organizer: ISMRM 25th Annual Meeting & Exhibition
  • Place of Presentation: Honolulu, HI, USA
  • Year and Date: 2017-04-22
  • Int'l Joint Research
• [Presentation] Visualization of irradiated liver parenchyma by observing delayed signal recovery on SPIO-enhanced MRI: an experimental study in a rat hepatoma model. (2017)
  • Author(s): Furuta T, Yamaguchi M, Minami M, Abe O, Fujii H.
  • Organizer: 第４５回日本磁気共鳴医学会大会
• [Presentation] A New Technique of SPIO-Enhanced MRI: Delayed Recovery of T2*-Weighted Signal Intensity as a Novel Diagnostic Marker for Visualization of Irradiated Liver Parenchyma. (2017)
  • Author(s): Furuta T, Yamaguchi M, Minami M, Abe O, Fujii H
  • Organizer: International Society for Magnetic Resonance in Medicine (ISMRM) 25th Annual Meeting & Exhibition
  • Int'l Joint Research