Upgrading of diagnostic functional imaging using integrated PET/MRI scanner system

• Project/Area Number: 16K10356
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Fukushima Medical University
• Principal Investigator: Ito Hiroshi 福島県立医科大学, 医学部, 教授 (20360357)
• Co-Investigator(Kenkyū-buntansha): 久保 均 福島県立医科大学, 公私立大学の部局等, 教授 (00325292) ; 富永 英之 福島県立医科大学, 公私立大学の部局等, 准教授 (00393348) ; 村上 丈伸 福島県立医科大学, 医学部, 助教 (00403428)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: PET/MRI / FDG / 認知症 / 体動補正 / 部分容積効果補正 / PET / MRI / brain / dementia / アルツハイマー病 / 放射線 / 神経科学

Outline of Final Research Achievements

Upgrading of measurement of glucose metabolism in the brain using integrated PET/MRI scanner system were applied. Using simultaneously acquired PET and MRI images by PET/MRI scanner system, the partial volume correction of PET images for brain atrophy could be performed in which the coregistration of PET and MR images could be avoid. All brain regions showed increases in uptake by partial volume correction, however, almost no changes in uptake were observed in the cerebellum and parahippocampal gyrus which showed highest gray matter fractions. The real-time motion correction of PET images using simultaneously measured MRI images could be performed by PET/MRI. The real-time motion correction revealed increasing accuracy of diagnostic imaging for dementia. Since the motion of head during PET scanning could not be avoid in patients with dementia and related neurodegenerative diseases, such real-time motion correction system might be useful.

Academic Significance and Societal Importance of the Research Achievements

認知症における画像診断は、SPECTによる脳血流評価とMRIによる脳形態の評価が臨床で行われているが、今後はPETを用いた脳内ブドウ糖消費量測定による脳神経機能の評価と脳内βアミロイド蓄積および脳内タウ蓄積の測定による脳病理変化の評価が行われるようになる。このような状況において、近年開発され普及し始めている同時収集型PET/MRI 装置を用いてこれらの測定を高精度化し、認知症の画像診断の高度化を図ることは意義のあることと思われる。本研究の成果は認知症のPET/MRI装置を用いた新たな総合画像診断学を確立していく上での礎となりうるものである。

Research Products

• [Journal Article] Imaging of Neuronal Activity in Awake Mice by Measurements of Flavoprotein Autofluorescence Corrected for Cerebral Blood Flow (2018)
  • Author(s): Takahashi Manami、Urushihata Takuya、Takuwa Hiroyuki、Sakata Kazumi、Takado Yuhei、Shimizu Eiji、Suhara Tetsuya、Higuchi Makoto、Ito Hiroshi
  • Journal Title: Frontiers in Neuroscience Volume: 11 Pages: 723-723
  • DOI: 10.3389/fnins.2017.00723
  • Peer Reviewed / Open Access
• [Journal Article] Water Diffusion in the Brain of Chronic Hypoperfusion Model Mice: A Study Considering the Effect of Blood Flow (2018)
  • Author(s): Urushihata Takuya、Takuwa Hiroyuki、 Seki Chie、 Tachibana Yasuhiko、Takahashi Manami、Jeff Kershaw、Takado Yuhei 、Aoki Ichio、Higuchi Makoto、Ito Hiroshi、Obata Takayuki
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 17 Issue: 4 Pages: 318-324
  • DOI: 10.2463/mrms.mp.2017-0149
  • NAID: 130007496873
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Neuromolecular basis of faded perception associated with unreality experience (2018)
  • Author(s): Yokokawa Keita、Ito Takehito、Takahata Keisuke、Takano Harumasa、Kimura Yasuyuki、Ichise Masanori、Ikoma Yoko、Isato Ayako、Zhang Ming-Rong、Kawamura Kazunori、Ito Hiroshi、Takahashi Hidehiko、Suhara Tetsuya、Yamada Makiko
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 8062-8062
  • DOI: 10.1038/s41598-018-26382-9
  • NAID: 120006551755
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of brain activity between motor imagery and mental rotation of the hand tasks: a functional magnetic resonance imaging study. (2018)
  • Author(s): Hamada H, Matsuzawa D, Sutoh C, Hirano Y, Chakraborty S, Ito H, Tsuji H, Obata T, Shimizu E.
  • Journal Title: Brain Imaging Behav, in press Volume: - Issue: 6 Pages: 1596-1606
  • DOI: 10.1007/s11682-017-9821-9
  • Peer Reviewed
• [Journal Article] Positron emission tomography of cerebral angiogenesis and TSPO expression in a mouse model of chronic hypoxia. (2017)
  • Author(s): Kanno I, Seki C, Takuwa H, Jin ZH, Boturyn D, Dumy P, Furukawa T, Saga T, Ito H, Masamoto K.
  • Journal Title: Journal of Cerebral Blood Flow and Metabolism Volume: 印刷中 Issue: 4 Pages: 687-696
  • DOI: 10.1177/0271678x16689800
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Measurement of psychological state changes at low dopamine transporter occupancy following a clinical dose of mazindol (2017)
  • Author(s): Yasuyuki Kimura, Jun Maeda, Makiko Yamada, Keisuke Takahata, Keita Yokokawa, Yoko Ikoma, Chie Seki, Hiroshi Ito, Makoto Higuchi, Tetsuya Suhara
  • Journal Title: Psychopharmacology Volume: 234 Issue: 3 Pages: 323-328
  • DOI: 10.1007/s00213-016-4464-x
  • Peer Reviewed
• [Journal Article] Changes in effective diffusivity for oxygen during neural activation and deactivation estimated from capillary diameter measured by two-photon laser microscope. (2017)
  • Author(s): Ito H, Takuwa H, Tajima Y, Kawaguchi H, Urushihata T, Taniguchi J, Ikoma Y, Seki C, Ibaraki M, Masamoto K, Kanno I.
  • Journal Title: J Physiol Sci. Volume: 67 Issue: 2 Pages: 325-330
  • DOI: 10.1007/s12576-016-0466-z
  • NAID: 40021113958
  • Peer Reviewed
• [Journal Article] Visual evaluation of kinetic characteristics of PET probe for neuroreceptors using a two-phase graphic plot analysis (2017)
  • Author(s): Ito H, Ikoma Y, Seki C, Kimura Y, Kawaguchi H, Takuwa H, Ichise M, Suhara T, Kanno I
  • Journal Title: Ann Nucl Med Volume: 31 Issue: 4 Pages: 273-282
  • DOI: 10.1007/s12149-017-1155-6
  • Peer Reviewed
• [Journal Article] Indications of success: Strategies for utilizing neuroimaging biomarkers in CNS drug discovery and development: CINP/JSNP working group report. (2017)
  • Author(s): Suhara T, Chaki S, Kimura H, Furusawa M, Matsumoto M, Ogura H, Negishi T, Saijo T, Higuchi M, Omura T, Watanabe R, Miyoshi S, Nakatani N, Yamamoto N, Liou SY, Takado Y, Maeda J, Okamoto Y, Okubo Y, Yamada M, Ito H, Walton NM, et al.
  • Journal Title: Int J Neuropsychopharmacol. Volume: 20(4) Pages: 285-294
  • DOI: 10.1093/ijnp/pyw111
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Normative data of dopaminergic neurotransmission functions in substantia nigra measured with MRI and PET: Neuromelanin, dopamine synthesis, dopamine transporters, and dopamine D2 receptors (2017)
  • Author(s): Ito H, Kawaguchi H, Kodaka F, Takuwa H, Ikoma Y, Shimada H, Kimura Y, Seki C, Kubo H, Ishii S, Takano H, Suhara T
  • Journal Title: Neuroimage Volume: 158 Pages: 12-17
  • DOI: 10.1016/j.neuroimage.2017.06.066
  • Peer Reviewed
• [Journal Article] Possible role of organic cation transporters in the distribution of [11C]sulpiride, a dopamine D2 receptor antagonist (2017)
  • Author(s): Takano H, Ito S, Zhang X, Ito H, Zhang MR, Suzuki H, Maeda K, Kusuhara H, Suhara T, Sugiyama Y
  • Journal Title: J Pharm Sci Volume: 106 Issue: 9 Pages: 2558-2565
  • DOI: 10.1016/j.xphs.2017.05.006
  • Peer Reviewed
• [Journal Article] Effects of point spread function-based image reconstruction on neuroreceptor binding in positron emission tomography study with [11C]FLB 457 (2016)
  • Author(s): Thongpraparn T, Ikoma Y, Shiraishi T, Yamaya T, Ito H
  • Journal Title: Radiol Phys Technol Volume: 9 Issue: 1 Pages: 127-137
  • DOI: 10.1007/s12194-015-0343-0
  • Peer Reviewed
• [Journal Article] Principal component analysis of multimodal neuromelanin MRI and dopamine transporter PET data provides a specific metric for the nigral dopaminergic neuronal density (2016)
  • Author(s): Kawaguchi H, Shimada H, Kodaka F, Suzuki M, Shinotoh H, Hirano S, Kershaw J, Inoue Y, Nakamura M, Sasai T, Kobayashi M, Suhara T, Ito H
  • Journal Title: PLoS One Volume: 11 Issue: 3 Pages: e0151191-e0151191
  • DOI: 10.1371/journal.pone.0151191
  • Peer Reviewed
• [Journal Article] Impact of spillover from white matter by partial volume effect on quantification of amyloid deposition with [11C]PiB PET (2016)
  • Author(s): Matsubara K, Ibaraki M, Shimada H, Ikoma Y, Suhara T, Kinoshita T, Ito H
  • Journal Title: Neuroimage Volume: 143 Pages: 316-324
  • DOI: 10.1016/j.neuroimage.2016.09.028
  • Peer Reviewed
• [Journal Article] Optimized workflow and imaging protocols for whole-body oncologic PET/MRI (2016)
  • Author(s): Ishii S, Hara T, Nanbu T, Suenaga H, Sugawara S, Kuroiwa D, Sekino H, Miyajima M, Kubo H, Oriuchi N, Ito H
  • Journal Title: Jpn J Radiol Volume: 34 Pages: 754-762
  • NAID: 50010139079
  • Peer Reviewed
• [Journal Article] ここまで進んだ核医学の最新型装置 PET/MRIによる診断と今後の展望 (2016)
  • Author(s): 伊藤 浩
  • Journal Title: 新医療 Volume: 43 Pages: 29-32
• [Journal Article] 核医学機器の進歩 PET/MRIの有用性と技術的展望 (2016)
  • Author(s): 伊藤 浩、石井士朗、南部武幸、久保 均、宮嶋正之、関野啓史、黒岩大地、末永博紀、菅原茂耕、長谷川 靖、橋本直人、織内 昇
  • Journal Title: Rad Fan Volume: 14 Pages: 28-30
• [Presentation] 福島県立医科大学におけるサイクロトロンの利用状況と今後の予定 (2018)
  • Author(s): 伊藤 浩
  • Organizer: 第8回南東北原子力シンポジウム
  • Invited
• [Presentation] ＰＥＴ核医学エキスパートセミナー 臨床1 脳神経 (2018)
  • Author(s): 伊藤 浩
  • Organizer: 第18回日本核医学会春季大会
  • Invited
• [Presentation] Correction of partial volume effect of cerebral glucose metabolism images measured by PET/MRI (2018)
  • Author(s): Ito H, Nambu T, Matsubara K, Kubo H, Oriuchi N, Ishii S
  • Organizer: SNMMI 2018 Annual Meeting
  • Int'l Joint Research
• [Presentation] ニューロイメージングプラットフォームにおけるO-15標識ガスPET文献データベースの作成 (2018)
  • Author(s): 伊藤 浩、松原佳亮、茨木正信、石井士朗、上野賢一、正木信夫、柏岡秀紀
  • Organizer: 第58回日本核医学会学術総会
• [Presentation] 核医学3：脳 神経変性疾患の核医学診断 (2017)
  • Author(s): 伊藤 浩
  • Organizer: 第76回日本医学放射線学会総会
  • Invited
• [Presentation] PET診断：押さえたいポイント．PET/MRIの臨床応用 (2017)
  • Author(s): 伊藤 浩
  • Organizer: 第53回日本医学放射線学会秋季臨床大会
  • Invited
• [Presentation] PET/MRIを用いた脳グルコース代謝画像の部分容積効果補正 (2017)
  • Author(s): 伊藤 浩、石井士朗、菅原茂耕、末永博紀、黒岩大地、関野啓史、宮嶋正之、長谷川 靖、橋本直人、南部武幸、久保 均、織内 昇、松原佳亮
  • Organizer: 第57回日本核医学会学術総会
• [Presentation] PETおよびMRIを用いた黒質におけるドーパミン作動性神経伝達機能のイメージング (2016)
  • Author(s): 伊藤 浩、川口拓之、生駒洋子、島田斉、木村泰之、関 千江、田桑弘之、菅野 巖、須原哲也
  • Organizer: 第56回日本核医学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2016-11-03
• [Presentation] Multimodal database of dopaminergic neurotransmission functions in substantia nigra measured by MRI and PET (2016)
  • Author(s): Ito H, Kawaguchi H, Ikoma Y, Shimada H, Kimura Y, Seki C, Takuwa H, Suhara T
  • Organizer: SNMMI 2016 Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2016-06-11
  • Int'l Joint Research
• [Remarks] 福島県立医科大学放射線医学講座ホームページ
  • URL: http://www.fmu.ac.jp/cms/rad/index.html
• [Remarks] 福島県立医科大学先端臨床研究センターホームページ
  • URL: http://www.fmu.ac.jp/home/acrc/