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Personalized radiosensitized radioimmunotherapy for peritoneal dissemination

Research Project

Project/Area Number 16K10375
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNational Institutes for Quantum and Radiological Science and Technology

Principal Investigator

Yoshii Yukie  国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 分子イメージング診断治療研究部, 主幹研究員(定常) (10397242)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords核医学 / PET / がん / 放射線 / 放射免疫療法 / 三次元培養 / 増感剤 / 個別化 / 放射線増感剤 / 個別化医療
Outline of Final Research Achievements

There is currently no effective treatment for peritoneal dissemination, and development of new treatment is needed. Radioimmunotherapy with antibodies labeled with therapeutic radionuclides is a promising method to treat peritoneal dissemination. We have previously reported that the radioimmunotherapy using the radionuclide 64Cu-labeled anti-EGFR antibody was effective for peritoneal dissemination of gastrointestinal cancers. However, further optimization is desired for use of this therapy. In this study, we developed a method to select sensitizers that are effective in radioimmunotherapy with 64Cu-labeled anti-EGFR antibody, with a 3D tumor cell culture screening. Also, we demonstrated that the drugs selected by the sensitizer screening are actually effective in vivo.

Academic Significance and Societal Importance of the Research Achievements

消化器がんは、本邦で罹患数が多く、死因上位を占める疾患である。また、消化器がんにおける腹腔内微小転移は現在有効な治療法がなく、新規治療法の開発が求められている。本研究では、3Dがん培養スクリーニングを用い、抗EGFR放射免疫療法においてがん特性に応じた効果的な増感剤を選択する方法を開発した。また、選択増感剤が、腹腔内微小転移に対し効果があることをマウスモデルを用い実証した。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] 64Cu-intraperitoneal radioimmunotherapy: a novel approach for adjuvant treatment in a clinically relevant preclinical model of pancreatic cancer2019

    • Author(s)
      Yoshii Yukie、Matsumoto Hiroki、Yoshimoto Mitsuyoshi、Oe Yoko、Zhang Ming-Rong、Nagatsu Kotaro、Sugyo Aya、Tsuji Atsushi B.、Higashi Tatsuya
    • Journal Title

      Journal of Nuclear Medicine

      Volume: - Issue: 10 Pages: 1437-1443

    • DOI

      10.2967/jnumed.118.225045

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrated treatment using intraperitoneal radioimmunotherapy and positron emission tomography-guided surgery with <sup>64</sup>Cu-labeled cetuximab to treat early- and late-phase peritoneal dissemination in human gastrointestinal cancer xenografts2018

    • Author(s)
      Yoshii Yukie、Yoshimoto Mitsuyoshi、Matsumoto Hiroki、Tashima Hideaki、Iwao Yuma、Takuwa Hiroyuki、Yoshida Eiji、Wakizaka Hidekatsu、Yamaya Taiga、Zhang Ming-Rong、Sugyo Aya、Hanadate Sayaka、Tsuji Atsushi B.、Higashi Tatsuya
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 48 Pages: 28935-28950

    • DOI

      10.18632/oncotarget.25649

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Evaluation of a PET-guided surgery with 64Cu-labeled cetuximab to resect tumors deeply located in the mouse peritoneal cavity2018

    • Author(s)
      Yukie Yoshii, Hideaki Tashima, Yuma Iwao, Hiroyuki Takuwa, Eiji Yoshida, Hidekatsu Wakizaka, Taiga Yamaya, Mitsuyoshi Yoshimoto, Hiroki Matsumoto, Ming-Rong Zhang, Aya Sugyo, Tsuji B Atsushi, Tatsuya Higashi
    • Organizer
      12th World Congress of the World Federation of Nuclear Medicine and Biology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PET-guided surgery system with 64Cu-PCTA-cetuximab for accurate resection of intraperitoneal tumors in a mice model2018

    • Author(s)
      Yukie Yoshii, Hideaki Tashima, Yuma Iwao, Hiroyuki Takuwa, Eiji Yoshida, Hidekatsu Wakizaka, Taiga Yamaya, Mitsuyoshi Yoshimoto, Hiroki Matsumoto, Ming-Rong Zhang, Aya Sugyo, Atsushi B Tsuji, Tatsuya Higashi
    • Organizer
      第13回日本分子イメージング学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Efficacy of combination use of intraperitoneal radioimmunotherapy and PET-guided surgery with 64Cu-labeled-cetuximab in a mice model of colon cancer peritoneal dissemination2018

    • Author(s)
      Yukie Yoshii, Mitsuyoshi Yoshimoto, Hiroki Matsumoto, Hideaki Tashima, Yuma Iwao, Hiroyuki Takuwa, Eiji Yoshida, Hidekatsu Wakizaka, Taiga Yamaya, Ming-Rong Zhang, Aya Sugyo, Sayaka Hanadate, Atsushi B. Tsuji, Tatsuya Higashi
    • Organizer
      SNM Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Feasibility of a PET-guided surgery system with 64Cu-labeled-cetuximab in an orthotopic mouse model of pancreatic cancer2018

    • Author(s)
      Kohei Sakurai, Yukie Yoshii, Hideaki Tashima, Yuma Iwao, Yoko Oe, Mineko Igarashi, Sayaka Hanadate, Eiji Yoshida, Hidekatsu Wakizaka, Taiga Yamaya, Mitsuyoshi Yoshimoto, Hiroki Matsumoto, Ming-Rong Zhang, Tsuji B Atsushi, Tatsuya Higashi
    • Organizer
      SNM Annual Meeting 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腹膜播種に対する64Cu標識セツキシマブを用いた腹腔内放射免疫療法の有用性の検討2017

    • Author(s)
      吉井 幸恵, 吉本 光喜, 松本 博樹, 張 明栄, 須尭 綾, 辻 厚至, 東 達也
    • Organizer
      第57回日本核医学会学術総会, 日本核医学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Intraperitoneal radioimmunotherapy (ipRIT) with 64Cu-PCTA-cetuximab to treat peritoneal dissemination of colon cancer in a mice model of peritoneal seeding2017

    • Author(s)
      Yukie Yoshii, Mitsuyoshi Yoshimoto, Hiroki Matsumoto, Ming-Rong Zhang, Aya Sugyo, Tsuji B Atsushi, Tatsuya Higashi
    • Organizer
      SNM Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 放射性64Cuを用いたがん診断治療法開発2016

    • Author(s)
      吉井幸恵
    • Organizer
      第16回放射性医薬品・画像診断薬研究会
    • Place of Presentation
      京都 みやこめっせ
    • Year and Date
      2016-10-01
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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