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Diagnostic System Development and Clinical Application of the Cardiac Damage after Radiotherapy

Research Project

Project/Area Number 16K10388
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionMie University

Principal Investigator

Nomoto Yoshihito  三重大学, 医学系研究科, 寄附講座教授 (10252363)

Co-Investigator(Kenkyū-buntansha) 佐久間 肇  三重大学, 医学系研究科, 教授 (60205797)
北川 覚也  三重大学, 医学系研究科, 寄附講座教授 (50378353)
中山 良平  立命館大学, 理工学部, 教授 (20402688)
Project Period (FY) 2016-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords放射線治療 / 心臓障害 / 心筋血流量 / 画像解析 / 画像情報 / 心臓CT検査
Outline of Final Research Achievements

For radiation cardiac injury, the relationship between irradiation dose and cardiac injury has not been clarified. We developed a system to fuse dose distribution curve with cardiac CT images and analyzed the relationship between radiation dose and cardiac damage. Twenty-five esophageal cancer patients who received radiotherapy underwent cardiac perfusion CT three months after irradiation. In irradiated hearts, myocardial blood flow was shown to be significantly reduced in areas irradiated with 20 Gy or more.

Academic Significance and Societal Importance of the Research Achievements

食道癌や乳癌、肺癌などの胸部悪性腫瘍に放射線治療が行われた場合、晩発性有害事象として心臓障害がしばしば問題となる。放射線による心臓障害は心筋の血流量低下や心筋の線維化などが指摘されているが、これらの障害と放射線の照射線量との相関関係は明らかにされていない。これまで、30Gy以上の照射で心臓の障害が生じるとされてきたが、今回の研究では、より少ない線量で心筋の障害が起こることがわかり、放射線治療の計画をする際には20Gy以上照射される領域をなるべく少なくするべきであることが示唆された。

Report

(8 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2022 2019

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Preliminary results of reduced myocardial blood flow in the subacute phase after radiation therapy for thoracic esophageal cancer: A quantitative analysis with stress dynamic myocardial computed tomography perfusion imaging2022

    • Author(s)
      Takada A, Ichikawa Y, ..., Nomoto Y, et al.
    • Journal Title

      Radiotherapy and Oncology

      Volume: 177 Pages: 191-196

    • DOI

      10.1016/j.radonc.2022.11.002

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 食道癌に対する放射線治療後の心臓障害2019

    • Author(s)
      高田彰憲、野本由人
    • Organizer
      日本画像医学会
    • Related Report
      2019 Research-status Report 2018 Research-status Report

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Published: 2016-04-21   Modified: 2024-01-30  

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