Prediction of radiosensitivity with salivary metabolomes

• Project/Area Number: 16K10404
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tokyo Medical University
• Principal Investigator: Tokuuye Koichi 東京医科大学, 医学部, 特任教授 (00334061)
• Co-Investigator(Kenkyū-buntansha): 杉本 昌弘 東京医科大学, 医学部, 教授 (30458963)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: メタボローム / 唾液 / 肺癌 / 放射線肺臓炎 / 唾液メタボローム / 非小細胞肺癌 / 放射線感受性 / 放射線障害 / 放射線治療

Outline of Final Research Achievements

Radiation pneumonitis (RP) can be life-threatening and cause a limiting factor of radiotherapy. Several factors associated with RP have been found by many researchers, however, RP prediction before radiotherapy is still difficult because patient-related factors are not fully understood. To investigate personalized risk factor, saliva samples were collected for patients with lung cancer who received radiotherapy, and metabolome analysis was performed. As a result, three metabolites were detected as an independent prognostic factors among about 500 metabolomes before radiotherapy. This study showed that these procedures can contribute to personalized radiation therapy.

Academic Significance and Societal Importance of the Research Achievements

放射線肺臓炎は肺癌の放射線治療において致死的な副作用である。照射線量、照射体積に依存するほか種々の危険因子が知られているものの、個人差が大きいために、予め副作用を予測して治療を進めることは困難である。そこで、患者の負担をかけずに放射線肺臓炎の個別化予測因子を検索するために唾液メタボロームに注目して、その有効性を検討した。クラスター解析の結果、放射線治療前に放射線肺臓炎の発生に関連する3種類のメタボロームを検出することができた。この因子は個人差に起因するものであり、放射線治療の個別化に貢献するものである。個別化医療が叫ばれる中で意義深い結果と考えられる。

Research Products

• [Journal Article] Prognostic impact of solid tumor component diameter in early-stage non-small cell lung carcinoma treated with intensity-modulated fractionated radiotherapy: a retrospective analysis impact of solid tumor component diameter in NSCLC treated with IMRT (2020)
  • Author(s): Itonaga Tomohiro、Mikami Ryuji、Okubo Mitsuru、Saito Tatsuhiko、Shiraishi Sachika、Sugahara Shinji、Tokuuye Koichi、Saito Kazuhiro
  • Journal Title: The British Journal of Radiology Volume: 93 Issue: 1109
  • DOI: 10.1259/bjr.20191027
  • Peer Reviewed
• [Journal Article] Phase II study of compensator-based non-coplanar intensity-modulated radiotherapy for Stage I non-small-cell lung cancer (2019)
  • Author(s): Itonaga Tomohiro、Mikami Ryuji、Nakayama Hidetsugu、Saito Tatsuhiko、Shiraishi Sachika、Okubo Mitsuru、Sugahara Shinji、Ikeda Norihiko、Tokuuye Koichi
  • Journal Title: Journal of Radiation Research Volume: 60 Issue: 3 Pages: 387-393
  • DOI: 10.1093/jrr/rrz009
  • Peer Reviewed
• [Journal Article] Predicting risk factors for radiation pneumonitis after stereotactic body radiation therapy for primary or metastatic lung tumors. (2017)
  • Author(s): 1.Okubo M, Itonaga T, Saito T, Shiraishi S, Mikami R, Nakayama H, Sakurada A, Sugahara S, Koizumi K, Tokuuye K.
  • Journal Title: Br J Radiol. Volume: 「－」 Issue: 1073 Pages: 20160508-20160508
  • DOI: 10.1259/bjr.20160508
  • Peer Reviewed
• [Presentation] Radiation pneumonitis predictive factors using saliva metabolomes for non-small cell lung cancer (2020)
  • Author(s): Sachika Shiraishi, Koichi Tokuuye
  • Organizer: European Congress of Radiology
  • Int'l Joint Research
• [Presentation] 非小細胞肺癌に対する唾液メタボローム解析を用いた 放射線肺臓炎発生予測についての研究 (2019)
  • Author(s): 白石 沙眞、徳植 公一
  • Organizer: 日本放射線腫瘍学会