Cellular senescence induced by chemo/radio-therapy as new therapeutic opportunity of mammary tumors.
| Project/Area Number |
16K10486
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Miyagi Prefectural Hospital Organization Miyagi Cancer Center |
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Principal Investigator |
Kawai Masaaki 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80513530)
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| Co-Investigator(Kenkyū-buntansha) |
島 礼 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 部長 (10196462)
角川 陽一郎 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (60221173)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 乳がん / 補助療法 / 細胞老化 / 代謝 / 化学療法 / 治療抵抗性 / 乳腺外科学 |
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| Outline of Final Research Achievements |
Tumor cells often undergo cellular senescence when treated with DNA-damaging agent or radio-therapy (TIS: therapy-induced senescence) in addition to cell death. TIS cells are thought to survive longer time, and promotes relapse and/or emergence of therapy-resistant tumors by various mechanisms. In this study, we tried to understand metabolic reprograming during TIS, and to explore it as new therapeutic target in order to improve adjuvant therapy of mammary tumors.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、補助療法として各種分子標的治療の発展は目覚ましいが、それらの恩恵を受けられるのは一部患者に限られる。よって、従来型の化学療法・放射線療法は今後も引き続き重要で、より一層の治療効果向上や副作用改善が求められている。とくに前者に関し、治療抵抗性の解明が大きなブレークスルーになると期待されている。本研究にて、TISに伴う代謝変化や関連表現型、およびそれらの分子メカニズムの一部を明らかにすることが出来た。新たな乳がん補助療法の開発への応用が期待される。
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.2018
Author(s)
M Morita, T Sato, M Nomura, Y Sakamoto, Y Inoue, R Tanaka, S Ito, K Kurosawa, K Yamaguchi, Y Sugiura, H Takizaki, Y Yamashita, R Katakura, I Sato, Y Okada, H Watanabe, G Kondoh, et al.
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Journal Title
Cancer Cell
Volume: 12
Issue: 3
Pages: 355-367
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Ex vivo model of non-small cell lung cancer using mouse lung epithelial cells.2017
Author(s)
Sato T, Morita M, Tanaka R, Inoue Y, Nomura M, Sakamoto Y, Miura K, Ito S, Sato I, Tanaka N, Abe J, Takahashi S, Kawai M, Sato M, Hippo Y, Shima H, Okada Y, Tanuma N
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Journal Title
Oncol Lett.
Volume: 14(6)
Pages: 6863-6868
DOI
Related Report
Peer Reviewed / Open Access
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