Identification of molecules involved in genomic damage and their blood monitoring

• Project/Area Number: 16K10514
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Jichi Medical University
• Principal Investigator: SUZUKI Koichi 自治医科大学, 医学部, 准教授 (70332369)
• Co-Investigator(Kenkyū-buntansha): 力山 敏樹 自治医科大学, 医学部, 教授 (80343060)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 染色体不安定性 / Satellite α transcript / セントロメア / ゲノムダメージ / 多発癌 / DNA脱メチル化異常 / 血中モニタリング / Satellite α tanscript / 脱メチル化異常 / 発癌リスク / 癌リスク / Satelliteαtranscript / satellite alpha / ゲノムのダメージ / 遺伝子修飾異常 / 脱メチル化レベル / 染色体分配 / Satelliteα

Outline of Final Research Achievements

(1) Induction of chromosomal instability: We constructed lentiviral vectors expressing SAT and then infected human mammary epithelial cells with these vectors. Immunocytochemistry revealed the rates of abnormal segregations of chromosomes, micronuclei and anaphase bridging were significantly higher in the cells with SAT overexpression than in those without. An array CGH identified the specific chromosomes of 8q and 20q as frequent sites of copy number alterations in cells with SAT overexpression (IJO 2018).(2) Field cancerization for the development of multiple cancers: We demonstrated for the first time a strong association between SAT expression levels in normal breast tissues and the development of bilateral breast cancer (BBC),as well as multiple primary cancer (MPC),in other organs when patients with breast cancer lack BRCA related features. These patients exhibited a 22 and 13fold increased risk for the development of BBC and MPC, respectively (Oncology reports 2019).

Academic Significance and Societal Importance of the Research Achievements

本研究は、SATが介在する染色体不安定性のメカニズムに脱メチル化異常を関連づけて一連のプロセスを検証する独創的な研究課題です。SATが誘導するゲノムダメージの標的分子を特定し、それを血中モニタリングする事で発がんリスクのマーカーとして臨床応用が期待されます。個人のゲノムプロファイルを特定し、その標的分子を簡便かつ低侵襲な方法で経時的に追跡する一連の手法は、発癌リスクの特定のみならず、炎症性疾患や成人病といった複雑な要因からなる様々な疾患にも応用が可能です。リアルタイムに個人の疾患プロファイルの変化を捉え、病気の発症を予測する新たな個別化医療のアプローチです。

Research Products

• [Int'l Joint Research] IMPPC(スペイン)
• [Journal Article] Palliative Radiotherapy and Ramucirumab Induced Severe Esophageal Stenosis. (2020)
  • Author(s): Keiko Akahane, Katsuyuki Shirai, Masaru Wakatsuki, Kazunari Ogawa, Kyosuke Minato, Kouhei Hamamoto, Satoru Takahashi, Koichi Suzuki, Jun Takahashi, Toshiki Rikiyama
  • Journal Title: Clinical Case Reports Volume: 0 Issue: 5 Pages: 1-4
  • DOI: 10.1002/ccr3.2751
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer. (2019)
  • Author(s): Fumiaki Watanabe, Koichi Suzuki*, Sawako Tamaki, Iku Abe, Yuhei Endo, Yuji Takayama, Hideki Ishikawa, Nao Kakizawa, Masaaki Saito, Kazushige Futsuhara, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama
  • Journal Title: PLOS ONE Volume: 14 Issue: 12 Pages: e0227366-e0227366
  • DOI: 10.1371/journal.pone.0227366
  • Peer Reviewed / Open Access
• [Journal Article] Temporary loss of consciousness during cetuximab treatment of a patient with metastatic colon cancer: a case report. (2019)
  • Author(s): Taro Fukui,Koichi Suzuki,Sawako Tamaki,Iku Abe,Yuhei Endo,Hideki Ishikawa,Nao Kakizawa,Fumiaki Watanabe,Masaaki Saito,Shingo Tsujinaka,Kazushige Futsuhara,Yasuyuki Miyakura,Hiroshi Noda,Toshiki Rikiyama
  • Journal Title: Surgical case reports Volume: 5 Issue: 1 Pages: 145-145
  • DOI: 10.1186/s40792-019-0707-5
  • Peer Reviewed / Open Access
• [Journal Article] High relative levels of satellite alpha transcripts predict increased risk of bilateral breast cancer and multiple primary cancer in patients with breast cancer and lacking BRCA_related clinical features. (2019)
  • Author(s): Nao Kakizawa,Koichi Suzuki,Iku Abe,Yuhei Endo,Sawako Tamaki,Hideki Ishikawa,Fumiaki Watanabe,Kosuke Ichida,Masaaki Saito,Kazusige Futsuhara,Fumio Konishi,Toshiki Rikiyama
  • Journal Title: Oncology reports Volume: 42 Pages: 857-865
  • DOI: 10.3892/or.2019.7182
  • Peer Reviewed
• [Journal Article] Multiple primary malignancies of six organs in a Japanese male patient: A case report. (2019)
  • Author(s): Yuta Muto,Koichi Suzuki,Takaharu Kato,Kosuke Ichida,Yuji Takayama,Taro Fukui,Nao Kakizawa,Fumiaki Watanabe,Yuji Kaneda,Hiroshi Noda,Toshiki Rikiyama
  • Journal Title: Molecular and clinical oncology Volume: 10 Pages: 511-515
  • DOI: 10.3892/mco.2019.1819
  • Peer Reviewed / Open Access
• [Journal Article] Monitoring circulating tumor DNA revealed dynamic changes in KRAS status in patients with metastatic colorectal (2018)
  • Author(s): Yuji Takayama, Koichi Suzuki, Yuta Muto, Kosuke Ichida, Taro Fukui, Nao Kakizawa, Hideki Ishikawa, Fumiaki Watanabe, Fumi Hasegawa, Masaaki Saito, Shingo Tsujinaka, Kazushige Futsuhara, Yasuyuki Miyakura, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama
  • Journal Title: Oncotarget Volume: 9 Issue: 36 Pages: 24398-24413
  • DOI: 10.18632/oncotarget.25309
  • Peer Reviewed / Open Access
• [Journal Article] Methylation-Sensitive Amplification Length Polymorphism (MS-AFLP) Microarrays for Epigenetic Analysis of Human Genomes (2018)
  • Author(s): Alonso Sergio、Suzuki Koichi、Yamamoto Fumiichiro、Perucho Manuel
  • Journal Title: Methods in molecular biology Volume: 1766 Pages: 137-156
  • DOI: 10.1007/978-1-4939-7768-0_8
  • ISBN: 9781493977673, 9781493977680
  • Peer Reviewed
• [Journal Article] Overexpression of satellite alpha transcripts leads to chromosomal instability via segregation errors at specific chromosomes. (2018)
  • Author(s): Ichida K, Suzuki K, Fukui T, Takayama Y, Kakizawa N, Watanabe F, Ishikawa H, Muto Y, Kato T, Saito M, Futsuhara K, Miyakura Y, Noda H, Ohmori T, Konishi F, Rikiyama T.
  • Journal Title: Int J Oncol. Volume: - Pages: 1685-1693
  • DOI: 10.3892/ijo.2018.4321
  • Peer Reviewed / Open Access
• [Journal Article] A High Abdominal Aortic Calcification Score on CT is a Risk Factor for Postoperative Pancreatic Fistula in Elderly Patients Undergoing Pancreaticoduodenectomy (2017)
  • Author(s): Kakizawa Nao、Noda Hiroshi、Watanabe Fumiaki、Ichida Kosuke、Suzuki Koichi、Rikiyama Toshiki
  • Journal Title: World Journal of Surgery Volume: 42 Issue: 4 Pages: 1129-1137
  • DOI: 10.1007/s00268-017-4240-z
  • Peer Reviewed
• [Journal Article] En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer (2017)
  • Author(s): Kaneda Yuji、Noda Hiroshi、Endo Yuhei、Kakizawa Nao、Ichida Kosuke、Watanabe Fumiaki、Kato Takaharu、Miyakura Yasuyuki、Suzuki Koichi、Rikiyama Toshiki
  • Journal Title: World Journal of Gastrointestinal Oncology Volume: 9 Issue: 9 Pages: 372-372
  • DOI: 10.4251/wjgo.v9.i9.372
  • Peer Reviewed / Open Access
• [Journal Article] Significance of the Difference in the Size of Liver Tumors in the Management of Patients with Colorectal Liver Metastases (2017)
  • Author(s): Ichida Kosuke、Suzuki Koichi、Fukui Taro、Takayama Yuji、Kakizawa Nao、Muto Yuta、Kato Takaharu、Hasegawa Fumi、Watanabe Fumiaki、Kaneda Yuji、Kikugawa Rina、Saito Masaaki、Tsujinaka Shingo、Futsuhara Kazushige、Miyakura Yasuyuki、Noda Hiroshi、Kiyozaki Hirokazu、Rikiyama Toshiki
  • Journal Title: Journal of Molecular and Genetic Medicine Volume: 11 Issue: 1
  • DOI: 10.4172/1747-0862.1000254
  • Peer Reviewed / Open Access
• [Journal Article] Morphological response contributes to patient selection for rescue liver resection in chemotherapy patients with initially un-resectable colorectal liver metastasis (2017)
  • Author(s): Suzuki Koichi、Muto Yuta、Ichida Kosuke、Fukui Taro、Takayama Yuji、Kakizawa Nao、Kato Takaharu、Hasegawa Fumi、Watanabe Fumiaki、Kaneda Yuji、Kikukawa Rina、Saito Masaaki、Tsujinaka Shingo、Futsuhara Kazushige、Takata Osamu、Noda Hiroshi、Miyakura Yasuyuki、Kiyozaki Hirokazu、Konishi Fumio、Rikiyama Toshiki
  • Journal Title: Oncology Letters Volume: 14 Issue: 2 Pages: 1491-1499
  • DOI: 10.3892/ol.2017.6338
  • Peer Reviewed / Open Access
• [Journal Article] Pitfalls of KRAS Testing for Treating Patients with Metastatic Colorectal Cancer (2016)
  • Author(s): Suzuki K, Rikiyama T
  • Journal Title: J Clin Epigenet Volume: 2-2 Issue: 2 Pages: 18-27
  • DOI: 10.21767/2472-1158.100018
  • Peer Reviewed
• [Journal Article] Clinical characteristics of synchronous colorectal cancers in Japan (2016)
  • Author(s): Kato T, Alonso S, Muto Y, Noda H, Miyakura Y, Suzuki K, Tsujinaka S, Saito M, Perucho M, Rikiyama T
  • Journal Title: World journal of surgical oncology Volume: 14 Issue: 1 Pages: 272-272
  • DOI: 10.1186/s12957-016-1027-x
  • Peer Reviewed / Open Access
• [Journal Article] Heterogeneous expression of zinc-finger E-box-binding homeobox 1 plays a pivotal role in metastasis via regulation of miR-200c in epithelial-mesenchymal transition (2016)
  • Author(s): Muto Y, Suzuki K, Kato T, Tsujinaka S, Ichida K, Takayama Y, Fukui T, Kakizawa N, Watanabe F, Saito M, Futsuhara K, Noda H, Miyakura Y, Konishi F and Rikiyama
  • Journal Title: Int J Oncol. Volume: 49(3) Issue: 3 Pages: 1057-1067
  • DOI: 10.3892/ijo.2016.3583
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Significance of monitoring plasma vascular endothelial growth factor signals during treatment of colorectal cancer patients. (2019)
  • Author(s): Nao Kakizawa, Koichi Suzuki, Hideki Ishikawa, Fumiaki Watanabe, Fumi Hasegawa, Rina Kikugawa, Shingo Tsujinaka, Kazushige Futsuhara, Yasuyuki Miyakura, Toshiki Rikiyama
  • Organizer: Gastrointestinal Cancers Symposium
  • Int'l Joint Research
• [Presentation] Clinical significance of monitoring KRAS in tissue and plasma of pancreatic cancer patients. (2019)
  • Author(s): Fumiaki Watanabe, Koichi Suzuki, Yuhei Endo, Hideki Ishikawa, Nao Kakizawa, Hiroshi Noda, Toshiki Rikiyama
  • Organizer: Gastrointestinal Cancers Symposium
  • Int'l Joint Research
• [Presentation] 上行結腸癌術後異時性孤発性胃壁転移の1例 (2019)
  • Author(s): 兼光梨奈、笠原尚哉、相澤栄俊、遠藤裕平、加藤高晴、野田弘志、鈴木浩一、山田茂樹、力山敏樹
  • Organizer: 日本消化器病学会関東支部第54回例会
• [Presentation] 多臓器浸潤局所進行右側結腸癌に対する右半結腸切除+膵頭十二指腸切除の適応と治療成績の検討 (2019)
  • Author(s): 野田弘志、渡部文昭、加藤高晴、笠原尚哉、遠藤裕平、相澤栄俊、辻仲眞康、宮倉安幸、鈴木浩一、力山敏樹
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 膵頭十二指腸切除術における乳糜の発生状況と周術期危険因子の解析 (2019)
  • Author(s): 福井太郎、野田弘志、相澤栄俊、遠藤裕平、渡部文昭、笠原尚哉、加藤高晴、齊藤正昭、辻仲眞康、宮倉安幸、清崎浩一、鈴木浩一、力山敏樹
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 膵癌患者における血中KRASクローンモニタリングの有用性 (2019)
  • Author(s): 渡部文昭、鈴木浩一、相澤栄俊、遠藤裕平、笠原尚哉、加藤高晴、野田弘志、力山敏樹
  • Organizer: 第36回日本胆膵病態・生理研究会
• [Presentation] 反復配列におけるエピジェネティック異常をバイオマーカーとしたfield defectの評価 (2019)
  • Author(s): 齊藤正昭、鈴木浩一、市田晃佑、阿部 郁、遠藤裕平、田巻佐和子、石川英樹、柿澤奈緒、渡部文昭、蓬原一茂、力山敏樹
  • Organizer: 第28回日本癌病態治療研究
• [Presentation] ctDNA Gene Panelによる標的分子の同定とDigital PCRによる血液モニタリング (2019)
  • Author(s): 鈴木浩一、石川英樹、柿澤奈緒、渡部文昭、阿部 郁、遠藤裕平、田巻佐和子、齊藤正昭、辻仲眞康、蓬原一茂、宮倉安幸、野田弘志、清崎浩一、力山敏樹
  • Organizer: 第28回日本癌病態治療研究会
• [Presentation] 膵癌患者における血中KRASクローンモニタリングの有用性 (2019)
  • Author(s): 渡部文昭、鈴木浩一、相澤栄俊、遠藤裕平、笠原尚哉、加藤高晴、野田弘志、力山敏樹
  • Organizer: 第28回日本癌病態治療研究会
• [Presentation] 膵癌におけるKRAS変異のheterogeneityの検討 (2019)
  • Author(s): 渡部文昭、鈴木浩一、相澤栄俊、遠藤裕平、笠原尚哉、加藤高晴、野田弘志、力山敏樹
  • Organizer: 第50回膵臓学会大会
• [Presentation] 当院における下部進行直腸癌に対する術前治療の変遷と治療成績の比較 (2019)
  • Author(s): 長谷川芙美、宮倉安幸、辻仲眞康、菊川利奈、石川英樹、田巻佐和子、鈴木浩一、清崎浩一、野田弘志、力山敏樹
  • Organizer: 第74回日本消化器外科学会
• [Presentation] 直腸癌術後の一時的回腸ストーマ造設状態における補助化学療法の忍容性に関する検討 (2019)
  • Author(s): 高橋 洵、辻仲眞康、田巻佐和子、竹浪 努、福田臨太郎、長谷川芙美、菊川利奈、鈴木浩一、宮倉安幸、力山敏樹
  • Organizer: 第74回日本消化器外科学会
• [Presentation] 当院における胃癌に対するニボルマブの使用経験 (2019)
  • Author(s): 武藤雄太、齊藤正昭、町田枝里華、前本 遼、石岡大輔、鈴木浩一、清崎浩一、力山敏樹
  • Organizer: 第74回日本消化器外科学会
• [Presentation] 通常型膵管癌切除後長期生存例の検討 (2019)
  • Author(s): 笠原尚哉、野田弘志、相澤栄俊、遠藤裕平、渡部文昭、加藤高晴、鈴木浩一、力山敏樹
  • Organizer: 第74回日本消化器外科学会
• [Presentation] 胆管悪性腫瘍に対する肝切除術後に膵頭十二指腸切除術を行った2症例 (2019)
  • Author(s): 福井太郎、野田弘志、相澤栄俊、遠藤裕平、渡部文昭、笠原尚哉、加藤高晴、宮倉安幸、鈴木浩一、力山敏樹
  • Organizer: 第74回日本消化器外科学会
• [Presentation] 膵癌患者における血中KRASモニタリングの有用性 (2019)
  • Author(s): 渡部文昭、鈴木浩一、相澤栄俊、遠藤裕平、笠原尚哉、加藤高晴、野田弘志、力山敏樹
  • Organizer: 第17回日本消化器外科学会大会
• [Presentation] リキッドバイオプシーによるがん診療のパラダイムシフト～大腸癌の後方ライン治療の有効性 (2019)
  • Author(s): 鈴木浩一
  • Organizer: 第74回日本大腸肛門病学会
  • Invited
• [Presentation] Clinical significance of monitoring KRSA in tissue and serum of pancreatic cancer patients (2018)
  • Author(s): Watanabe F, Suzuki K, Ishikawa H, Endo Y, Ichida K, Takayama Y, Fukui T, Kakizawa N, Kasahara N, Kato T, Noda H, Rikiyama T
  • Organizer: Gastrointestinal Cancers Symposium
  • Int'l Joint Research
• [Presentation] Dynamics and characteristics of KRAS mutated circulating tumor DNA in patients with metastatic colorectal cancer during various treatments (2018)
  • Author(s): Takayama Y, Suzuki K, Ichida K, Fukui T, Kakizawa N, Watanabe F, Kikukawa R, Hasegawa F, Tsujinaka S, Miyakura Y, Konishi F, Rikiyama T
  • Organizer: Gastrointestinal Cancers Symposium
  • Int'l Joint Research
• [Presentation] Liquid biopsy leads to a paradigm shift in colorectal cancer treatments (2018)
  • Author(s): Suzuki K, Takayama Y, Kakizawa N, Ichida K, Fukui T, Watanabe F, Ishikawa H, Saito M, Miyakura Y, Rikiyama T
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] リキッドバイオプシーによる大腸癌診療のパラダイムシフト (2018)
  • Author(s): 鈴木浩一
  • Organizer: Saitama CRC Seminar
  • Invited
• [Presentation] 膵癌に対する組織と血中のKRASモニタリングの有用性 (2018)
  • Author(s): 渡部文昭、鈴木浩一、遠藤裕平、笠原尚哉、加藤高晴、齊藤正昭、辻仲眞康、宮倉安幸、野田弘志、清崎浩一、力山敏樹
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 膵癌に対する術前治療に組織と血中のKRASモニタリングは有用か (2018)
  • Author(s): 渡部文昭、鈴木浩一、力山敏樹
  • Organizer: 第104回日本消化器病学会総会学術集会
• [Presentation] Clinical significance of monitoring KRAS in tissue and plasma of pancreatic cancer patients (2018)
  • Author(s): Watanabe F
  • Organizer: 第17回自治医科大学シンポジウム
• [Presentation] Significance of monitoring vascular endothelial growth factor signals in blood during treatment of colorectal cancer patients (2018)
  • Author(s): Kakizawa N, Suzuki K, Ishikawa H, Watanabe F, Kikugawa R, Tsujinaka S, Miyakura Y, Rikiyama T
  • Organizer: 第17回自治医科大学シンポジウム
• [Presentation] Significance of monitoring VEGF signals in blood during treatment of colorectal cancer patient (2018)
  • Author(s): 柿澤奈緒、鈴木浩一、石川英樹、渡部文昭、辻仲眞康、宮倉安幸、力山敏樹
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] リキッドバイオプシーによるがん診療のパラダイムシフト (2018)
  • Author(s): 鈴木浩一
  • Organizer: 第27回日本がん転移学会
  • Invited
• [Presentation] DNA脱メチル化異常をバイオマーカーとする胃切除範囲への臨床応用 (2018)
  • Author(s): 齊藤正昭、清崎浩一、小櫃 保、伊瀬谷和輝、石岡大輔、辻仲眞康、宮倉安幸、鈴木浩一、野田弘志、力山敏樹
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] The clinical significance of KRAS monitoring in tumor tissues and blood of patients with pancreatic tumor (2017)
  • Author(s): Watanabe F, Suzuki K, Ichida K, Takayama Y, Fukui T, Kakizawa N, Rikiyama T
  • Organizer: Gastrointestinal Cancers Symposium
  • Int'l Joint Research
• [Presentation] Appearance of KRAS mutated circulating tumor DNA during various treatments for metastatic colorectal cancer patients (2017)
  • Author(s): Takayama Y, Suzuki K, Ichida K, Fukui T, Kakizawa N, Watanabe F, Hasegawa F, Tsujinaka S, Miyakura Y, Noda H, Rikiyama T
  • Organizer: Exosomes and Liquid Biopsies ASIA
  • Int'l Joint Research
• [Presentation] Liquid Biopsyによるがん診療のパラダイムシフト (2017)
  • Author(s): 鈴木浩一、高山裕司、渡部文昭、市田晃佑、福井太郎、柿澤奈緒、齊藤正昭、辻仲眞康、蓬原一茂、宮倉安幸、力山敏樹
  • Organizer: 第26回日本癌病態治療研究会
• [Presentation] セントロメア領域の脱メチル化は、染色体不安定性を誘導する (2017)
  • Author(s): 齊藤正昭、鈴木浩一、市田晃佑、高橋洵、石岡大輔、小櫃保、清崎浩一、力山敏樹
  • Organizer: 第89回日本胃癌学会総会
• [Presentation] 乳癌両側発生、多臓重複器発生に関わる染色体分配の異常とSatellite alpha transcripts (2017)
  • Author(s): 蓬原一茂、柿澤奈緒、鈴木浩一、齊藤正昭、市田晃佑、佐藤あい、吉沢あゆは、野口友里、尾本きよか、力山敏樹
  • Organizer: 第25回乳癌学会学術集会
• [Presentation] 膵腫瘍性病変における組織と血中のKrasモニタリングの臨床的意義 (2017)
  • Author(s): 渡部文昭、鈴木浩一、遠藤裕平、市田晃佑、福井太郎、柿澤奈緒、兼田裕司、野田弘志、力山敏樹
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 乳癌においてSatellite alpha transcript過剰発現が惹起する染色体不安定性 (2017)
  • Author(s): 市田晃佑、鈴木浩一、福井太郎、高山裕司、柿澤奈緒、渡部文昭、石川英樹、齊藤正昭、武藤雄太、加藤高晴、蓬原一茂、力山敏樹
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Specific chromosomes were impaired by overexpression of Satellite alpha transcript in breast cancer patients (2017)
  • Author(s): 市田晃佑、鈴木浩一、高山裕司、福井太郎、渡部文昭、柿澤奈緒、石川英樹、加藤高晴、齊藤正昭、力山敏樹
  • Organizer: 第16回自治医科大学シンポジウム
• [Presentation] 治療中の転移性大腸癌患者におけるKRAS変異型血中遊離DNA出現パターンの同定 (2017)
  • Author(s): 高山裕司、鈴木浩一、市田晃佑、福井太郎、渡部文昭、菊川利奈、長谷川芙美、辻仲眞康、宮倉安幸、野田弘志、小西文雄、力山敏樹
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Appearance and characteristic of KRAS mutated circulating tumor DNA in patients with metastatic colorectal cancer during various treatments (2017)
  • Author(s): 高山裕司
  • Organizer: 第16回自治医科大学シンポジウム
• [Presentation] リキッドバイオプシーによる癌治療のパラダイムシフト (2016)
  • Author(s): 20鈴木浩一、武藤雄太、市田晃佑、柿澤奈緒、齊藤正昭、力山敏樹
  • Organizer: 第20回日本がん分子標的治療学会学術集会
  • Place of Presentation: 別府
  • Year and Date: 2016-05-30
• [Presentation] Practical applications of "Liquid biopsy" in the colorectal cancer treatment (2016)
  • Author(s): 19Suzuki K, TakaYama Y, Ichida K, Fukui T, Kakizawa N, Obitsu T, Muto Y, Hasegawa F, Watanabe F, Kikukawa R, Kato T, Kaneda Y, Saito M, Tsujinaka S, Futuhara K, Miyakura Y, Noda H, Takada O, Kiyoszaki H, Rikiyama T
  • Organizer: 第37回癌免疫外科研究会
  • Place of Presentation: 川越
  • Year and Date: 2016-05-12
• [Presentation] Clinical applications of “Liquid biopsy” in the colorectal cancer treatment (2016)
  • Author(s): 1Suzuki K, Takayama Y, Ichida K, Fukui T, Kakizawa N, Watanabe F, Hasegawa F, Kikugawa R, Tsujinaka S, Miyakura Y, Rikiyama T
  • Organizer: Exosomes and Liquid Biopsies Asia
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2016-04-07
  • Int'l Joint Research
• [Presentation] Liquid biopsy leads to a paradigm shift in cancer diagnosis (2016)
  • Author(s): 18鈴木浩一、髙山裕司、市田晃佑、福井太郎、柿澤奈緒、渡部文昭、武藤雄太、齊藤正昭、辻仲眞康、宮倉安幸、力山敏樹
  • Organizer: 第116回日本外科学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2016-04-04
• [Presentation] Target chromosomes impaired by overexpression of Satellite alpha transcript in vitro (2016)
  • Author(s): 10Ichida K, Suzuki K, Fukui T, Takayama Y, Kakizawa N, Muto Y, Watanabe F, Saito M, Kato T, Rikiyama T
  • Organizer: International Association of Surgeons, Gastroenterologists and Oncologists,
  • Place of Presentation: Sendai, Japan
  • Int'l Joint Research
• [Book] 癌免疫カンファレンスルーム (2019)
  • Author(s): 鈴木 浩一、力山 敏樹
  • Total Pages: 4
  • Publisher: へるす出版