The Montoring Study on Esophageal Cancer by Serum Autoantibody Targeting RalA and/or NY-ESO-1

• Project/Area Number: 16K10520
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Toho University
• Principal Investigator: SHIMADA Hideaki 東邦大学, 医学部, 教授 (20292691)
• Co-Investigator(Kenkyū-buntansha): 日和佐 隆樹 千葉大学, 大学院医学研究院, 特任准教授 (30260251) ; 松下 一之 千葉大学, 医学部附属病院, 准教授 (90344994)
• Project Period (FY): 2016-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: SEREX / RalA / NY-ESO-1 / p53 / 食道癌 / 血清抗体 / 腫瘍マーカー

Outline of Final Research Achievements

One of the most immunogenic epitopes was selected from the RalA antigen and NY-ESO-1 antigen to develope ELISA kit for detecting serum antibody. We analyzed perioperative changes of serum autoantibody titers in esophageal cancer. We analyzed the clinical pathological significance of the autoantibodies, such as the positive rate, the risk of recurrence in positive and negative cases, and the effect on long-term survival. All three autoantibodies tend to have a relatively high positive rate even in the stage I / II stage. Since they rarely overlap with each other, the positive rate tends to increase significantly when used in combination. In relation to prognosis, antibody-positive cases tended to have a poorer prognosis, but the difference was not significant. Regarding the p53 antibody detection kit, we developed a new system using multiple peptide antigens to improve specificity. It was found that the specificity tended to be higher than that of the conventional system.

Academic Significance and Societal Importance of the Research Achievements

保険収載されている食道癌の血液腫瘍マーカー（CEA、SCC抗原、p53抗体）は、3種を併用しても進行癌の40%、早期癌の80%では3種すべてが陰性(triple negative)である。このため3種全てが陰性の症例では、治療効果判定や再発診断を頻繁な画像検査が必要となる。本研究では、自己抗体検査法として実用化されていない分子標的としてRalAならびにNY-ESO-1を同時標的とした新たな検査システムを構築し、比較的早期の段階から陽性率が高い検査系を確立することができた。この検査系を実用化することで、今後食道癌の早期診断や再発の早期診断が可能となる可能性があり、社会的意義が大きいと思われる。

Research Products

• [Journal Article] Prognostic Impact of Pretreatment Serum CYFRA Status in 1047 Patients with Esophageal Squamous Cell Carcinoma Who Underwent Radical Resection: A Japan Esophageal Society Promotion Research (2022)
  • Author(s): Ishioka Nobuki、Suzuki Takashi、Yajima Satoshi、Murakami Kentaro、Ohkura Yu、Fukuda Takashi、Yagi Koichi、Okamura Akihiko、Hoshino Isamu、Kunisaki Chikara、Nakajima Yasuaki、Narumiya Kosuke、Ogawa Ryo、Shimada Hideaki
  • Journal Title: Annals of Thoracic and Cardiovascular Surgery Volume: 28 Issue: 3 Pages: 163-170
  • DOI: 10.5761/atcs.oa.21-00195
  • NAID: 130008107269
  • ISSN: 1341-1098, 2186-1005
  • Peer Reviewed
• [Journal Article] New Assay System Elecsys Anti-p53 to Detect Serum Anti-p53 Antibodies in Esophageal Cancer Patients and Colorectal Cancer Patients: Multi-institutional Study (2021)
  • Author(s): Yajima Satoshi、Suzuki Takashi、Oshima Yoko、Shimada Hideaki etal.
  • Journal Title: Annals of Surgical Oncology Volume: 28 Issue: 7 Pages: 4007-4015
  • DOI: 10.1245/s10434-020-09342-4
  • Peer Reviewed
• [Journal Article] Association of Serum Anti-PCSK9 Antibody Levels with Favorable Postoperative Prognosis in Esophageal Cancer (2021)
  • Author(s): Ito Masaaki、Hiwasa Takaki、Oshima Yoko、Yajima Satoshi、Suzuki Takashi、Nanami Tatsuki、Sumazaki Makoto、Shiratori Fumiaki、Funahashi Kimihiko、Li Shu-Yang、Iwadate Yasuo、Yamagata Hiroki、Jambaljav Byambasteren、Takemoto Minoru、Yokote Koutaro、Takizawa Hirotaka、Shimada Hideaki
  • Journal Title: Frontiers in Oncology Volume: 11 Pages: 708039-708039
  • DOI: 10.3389/fonc.2021.708039
  • Peer Reviewed / Open Access
• [Journal Article] Identification of serum anti?striatin 4 antibodies as a common marker for esophageal cancer and other solid cancers (2021)
  • Author(s): Ito Masaaki、Hiwasa Takaki、Oshima Yoko、Yajima Satoshi、Suzuki Takashi、Nanami Tatsuki、Sumazaki Makoto、Shiratori Fumiaki、Funahashi Kimihiko、Takizawa Hirotaka、Kashiwado Koichi、Tochigi Naobumi、Shimada Hideaki
  • Journal Title: Molecular and Clinical Oncology Volume: 15 Issue: 5 Pages: 237-237
  • DOI: 10.3892/mco.2021.2399
  • Peer Reviewed
• [Journal Article] Preoperative low serum creatine kinase is associated with poor overall survival in the male patients with esophageal squamous cell carcinoma (2021)
  • Author(s): Murayama Kenji、Suzuki Takashi、Yajima Satoshi、Oshima Yoko、Nanami Tatsuki、Shiratori Fumiaki、Shimada Hideaki
  • Journal Title: Esophagus Volume: 19 Issue: 1 Pages: 105-112
  • DOI: 10.1007/s10388-021-00866-6
  • NAID: 40022800651
  • Peer Reviewed
• [Journal Article] Prognostic impact of p53 and/or NY-ESO-1 autoantibody induction in patients with gastroenterological cancers (2020)
  • Author(s): Hoshino Isamu、Nabeya Yoshihiro、Takiguchi Nobuhiro、Gunji Hisashi、Ishige Fumitaka、Iwatate Yosuke、Shiratori Fumiaki、Yajima Satoshi、Okada Rei、Shimada Hideaki
  • Journal Title: Annals of Gastroenterological Surgery Volume: 110 Issue: 3 Pages: 2004-2013
  • DOI: 10.1002/ags3.12325
  • Peer Reviewed / Open Access
• [Journal Article] Six autoantibodies as potential serum biomarkers of hepatocellular carcinoma: A prospective multicenter study (2020)
  • Author(s): Okada Rei、Otsuka Yuichiro、Wakabayashi Taiga、Shinoda Masahiro、Aoki Takeshi、Murakami Masahiko、Arizumi Shunichi、Yamamoto Masakazu、Aramaki Osamu、Takayama Tadatoshi、Wakiyama Shigeki、Yanaga Katsuhiko、Amikura Katsumi、Kaneko Hironori、Shimada Hideaki
  • Journal Title: International Journal of Cancer Volume: 147 Issue: 9 Pages: 2578-2586
  • DOI: 10.1002/ijc.33165
  • Peer Reviewed / Open Access
• [Journal Article] Inducing Multiple Antibodies to Treat Squamous Cell Esophageal Carcinoma (2020)
  • Author(s): Hoshino Isamu、Nabeya Yoshihiro、Takiguchi Nobuhiro、Gunji Hisashi、Ishige Fumitaka、Iwatate Yosuke、Kuwajima Akiko、Shiratori Fumiaki、Okada Rei、Shimada Hideaki
  • Journal Title: BMC cancer Volume: 20
  • DOI: 10.21203/rs.3.rs-18685/v1
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence of autoantibodies against Ras?like GTPases, RalA, in patients with gastric cancer (2020)
  • Author(s): Nanami Tatsuki、Hoshino Isamu、Ito Masaaki、Yajima Satoshi、Oshima Yoko、Suzuki Takashi、Shiratori Fumiaki、Nabeya Yoshihiro、Funahashi Kimihiko、Shimada Hideaki
  • Journal Title: Molecular and Clinical Oncology Volume: 13
  • DOI: 10.3892/mco.2020.2098
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impact of preoperative serum p53 antibody titers in 1487 patients with surgically treated esophageal squamous cell carcinoma: a multi-institutional study (2020)
  • Author(s): Takashi Suzuki、Satoshi Yajima、Akihiko Okamura、Naoya Yoshida、Yusuke Taniyama、Kentaro Murakami、Yu Ohkura、Yasuaki Nakajima、Koichi Yagi、Takashi Fukuda、Ryo Ogawa、Isamu Hoshino、Chikara Kunisaki、Kosuke Narumiya、Yasuhiro Tsubosa、Kazuhiko Yamada、Hideaki Shimada
  • Journal Title: Esophagus Volume: 18 Issue: 1 Pages: 65-71
  • DOI: 10.1007/s10388-020-00761-6
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Dermatomyositis Along with Esophageal Cancer and Screening of Serum Transcriptional Intermediary Factor 1 Gamma Antibodies in Various Cancer Patients (2020)
  • Author(s): Sumazaki Makoto、Kaneko Kaichi、Ito Masaaki、Oshima Yoko、Saito Fumi、Ogata Hideaki、Shibuya Kazutoshi、Shimada Hideaki
  • Journal Title: American Journal of Case Reports Volume: 21
  • DOI: 10.12659/ajcr.922004
  • Peer Reviewed
• [Journal Article] Anti-FIRΔexon2, a splicing variant form of PUF60, auto-antibody is detected in the sera of esophageal squamous cell carcinoma. (2019)
  • Author(s): Kobayashi S, Hiwasa T, Ishige T, Rahmutulla B, Kano M, Hoshino T, Minamoto T, Shimada H, Nomura F, Matsubara H, Matsushita K.
  • Journal Title: Cancer Sci. Volume: 4 Issue: 6 Pages: 1-10
  • DOI: 10.1111/cas.14024
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic and prognostic impacts of six autoantibodies against multiple tumor-associated antigens with hepatocellular carcinoma. (2019)
  • Author(s): Okada R, Hoshino I, Nabeya Y, Yokoi S, Kuwajima A, Tagawa M, Matsushita K, Otsuka Y, Shimada H
  • Journal Title: Toho Journal of Medicine Volume: 5 Pages: 93-100
  • NAID: 120006733004
  • Peer Reviewed
• [Journal Article] p53 molecular approach to diagnosis and treatment of esophageal squamous cell carcinoma (2018)
  • Author(s): Shimada Hideaki
  • Journal Title: Annals of Gastroenterological Surgery Volume: 2 Issue: 4 Pages: 266-273
  • DOI: 10.1002/ags3.12179
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of high serum p53 antibody titers in patients with esophageal squamous cell carcinoma (2018)
  • Author(s): Suzuki Takashi、Yajima Satoshi、Ishioka Nobuki、Nanami Tatsuki、Oshima Yoko、Washizawa Naohiro、Funahashi Kimihiko、Otsuka Seiko、Nemoto Tetsuo、Shimada Hideaki
  • Journal Title: Esophagus Volume: 15 Issue: 4 Pages: 294-300
  • DOI: 10.1007/s10388-018-0629-5
  • NAID: 40021670369
  • Peer Reviewed
• [Journal Article] Heat shock protein 90 inhibitors augment endogenous wild-type p53 expression but down-regulate the adenovirally-induced expression by inhibiting a proteasome activity (2018)
  • Author(s): Chai Kuan、Ning Xuerao、Nguyen Thao Thi Thanh、Zhong Boya、Morinaga Takao、Li Zhihan、Shingyoji Masato、Tada Yuji、Tatsumi Koichiro、Shimada Hideaki、Hiroshima Kenzo、Yamaguchi Naoto、Tagawa Masatoshi
  • Journal Title: Oncotarget Volume: 9 Issue: 40 Pages: 26130-26143
  • DOI: 10.18632/oncotarget.25452
  • Peer Reviewed / Open Access
• [Journal Article] Identification of specific and common diagnostic antibody markers for gastrointestinal cancers by SEREX screening using testis cDNA phage library (2018)
  • Author(s): Kobayashi Sohei、Hiwasa Takaki、Arasawa Takahiro、Kagaya Akiko、Ishii Sayaka、Shimada Hideaki、Ito Masaaki、Suzuki Masae、Kano Masayuki、Rahmutulla Bahityar、Kitamura Kouichi、Sawabe Yuji、Shin Hideo、Takiguchi Masaki、Nomura Fumio、Matsubara Hisahiro、Matsushita Kazuyuki
  • Journal Title: Oncotarget Volume: 9 Issue: 26 Pages: 18559-18569
  • DOI: 10.18632/oncotarget.24963
  • Peer Reviewed / Open Access
• [Journal Article] Five-year postsurgical monitoring of serum p53 antibody for locally advanced esophageal squamous cell carcinoma (2018)
  • Author(s): Kochi Ryosuke、Yajima Satoshi、Nanami Tatsuki、Suzuki Takashi、Oshima Yoko、Tokura Natsuki、Takatsuka Jun、Funahashi Kimihiko、Tochigi Naobumi、Shimada Hideaki
  • Journal Title: Clinical Journal of Gastroenterology Volume: 11 Issue: 4 Pages: 278-281
  • DOI: 10.1007/s12328-018-0839-3
  • Peer Reviewed / Open Access
• [Journal Article] Serum p53 antibody as a potential tumor marker in extrahepatic cholangiocarcinoma (2017)
  • Author(s): Okada Rei、Shimada Hideaki、Otsuka Yuichiro、Tsuchiya Masaru、Ishii Jun、Katagiri Toshio、Maeda Tetsuya、Kubota Yoshihisa、Nemoto Tetsuo、Kaneko Hironori
  • Journal Title: Surg Today Volume: 47 Issue: 12 Pages: 1492-1499
  • DOI: 10.1007/s00595-017-1540-8
  • Peer Reviewed / Open Access
• [Journal Article] Identification of novel serum autoantibodies against EID3 in non-functional pancreatic neuroendocrine tumors. (2017)
  • Author(s): Hontani K, Tsuchikawa T, Hiwasa T, Nakamura T, Ueno T, Kushibiki T, Takahashi M, Inoko K, Takano H, Takeuchi S, Dosaka-Akita H, Kuwatani M, Sakamoto N, Hatanaka Y, Mitsuhashi T, Shimada H, Shichinohe T, Hirano S.
  • Journal Title: Oncotarget Volume: 8 Issue: 63 Pages: 106206-106221
  • DOI: 10.18632/oncotarget.22175
  • NAID: 120006416017
  • Peer Reviewed / Open Access
• [Journal Article] Profiling of serum autoantibodies in Japanese patients with hepatocellular carcinoma. (2017)
  • Author(s): Okada Rei, Shimada Hideaki, Tagawa Masatoshi, Matsushita Kazuyuki, Otsuka Yuichiro, Kuwajima Akiko, Kaneko Hironori
  • Journal Title: Toho J Med Volume: 3 Pages: 84-92
  • NAID: 120006412193
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic and Prognostic Impact of Serum p53 Antibody Titration in Colorectal Cancer. (2017)
  • Author(s): Suzuki Takayuki, Funahashi Kimihiko, Ushigome Mitsunori, Koike Junichi, Nemoto Tetsuo, Shimada Hideaki
  • Journal Title: Toho J Med Volume: 3 Pages: 107-115
  • NAID: 120006422780
  • Peer Reviewed / Open Access
• [Journal Article] Presence of Autoantibodies against Ras-like GTPases in Serum in Stage I/II Breast Cancer. (2017)
  • Author(s): Kubota Yorichika, Ogata Hideaki, Otsuka Seiko, Kuwajima Akiko, Saito Fumi, Shimada Hideaki
  • Journal Title: Toho J Med Volume: 3 Pages: 125-130
  • NAID: 120006422782
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of hyperfibrinogenemia in patients with esophageal squamous cell carcinoma. (2017)
  • Author(s): Suzuki T, Shimada H, Nanami T, Oshima Y, Yajima S, Washizawa N, Kaneko H
  • Journal Title: Int J Clin Oncol Volume: - Issue: 3 Pages: 461-468
  • DOI: 10.1007/s10147-016-1087-5
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Midkine is a potential novel marker for malignant mesothelioma with different prognostic and diagnostic values from mesothelin. (2017)
  • Author(s): Ak G, Tada Y, Shimada H†, Metintas S, Ito M, Hiroshima K, Tagawa M, Metintas M
  • Journal Title: BMC cancer Volume: 17（1） Issue: 1 Pages: 212-212
  • DOI: 10.1186/s12885-017-3209-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A panel of autoantibodies against multiple tumor-associated antigens for detecting gastric cancer (2017)
  • Author(s): Hoshino, I., Nagata, M., Takiguchi, N., Nabeya, Y., Ikeda, A., Yokoi, S., Kuwajima, A., Tagawa, M., Matsushita, K., Yajima, S., Shimada, H.
  • Journal Title: Cancer Sci Volume: 108 Issue: 3 Pages: 308-315
  • DOI: 10.1111/cas.13158
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Three-year monitoring of serum p53 antibody during chemotherapy and surgery for stage IV rectal cancer. (2016)
  • Author(s): Suzuki T, Shimada H, Ushigome M, Koike J, Funahashi K, Nemoto T, Kaneko H
  • Journal Title: Clin J Gastroenterol Volume: 9（2） Issue: 2 Pages: 55-58
  • DOI: 10.1007/s12328-016-0633-z
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of serum autoantibodies against Ras-like GTPases, RalA, in patients with esophageal squamous cell carcinoma. (2016)
  • Author(s): Nanami, T., Shimada, H., Yajima, S., Oshima, Y., Matsushita, K., Nomura, F., Nagata, M., Tagawa, M., Otsuka, S., Kuwajima, A. and Kaneko, H
  • Journal Title: Esophagus Volume: 13 Issue: 2 Pages: 167-172
  • DOI: 10.1007/s10388-015-0510-8
  • NAID: 40020807867
  • Peer Reviewed / Open Access
• [Presentation] 食道癌患者血清におけるCENTA1 抗体レベルとの関係. (2021)
  • Author(s): 白鳥史明, 伊藤正朗, 日和佐隆樹, 鈴木隆, 谷島聡, 名波竜規, 大嶋陽幸, 船橋公彦, 島田英昭
  • Organizer: 第76回日本消化器外科学会総会
• [Presentation] 食道癌における腫瘍マーカーとしての血清抗Striatin4 抗体の同定. (2021)
  • Author(s): 伊藤正朗, 日和佐隆樹, 大嶋陽幸, 谷島 聡, 鈴木 隆, 名波竜規, 白鳥史明, 船橋公彦, 島田英昭
  • Organizer: 第76回日本消化器外科学会総会
• [Presentation] 食道癌患者血清におけるDAN 抗体レベルの上昇. (2021)
  • Author(s): 白鳥史明, 日和佐隆樹, 伊藤正朗, 鈴木 隆, 谷島 聡, 名波竜規, 大嶋陽幸, 船橋公彦, 島田英昭
  • Organizer: 第75回日本食道学会学術集会
• [Presentation] 食道癌におけるNYESO-1 抗体とp53 抗体の予後因子としての意義. (2021)
  • Author(s): 島田英昭
  • Organizer: 第185回日本胸部外科学会関東甲信越地方会
• [Presentation] 食道扁平上皮癌手術症例における術前術後血清p53抗体の推移と予後の解析. (2020)
  • Author(s): 酒井 悠, 鈴木 隆, 酒井隆光, 大嶋陽幸. 谷島 聡, 島田英昭
  • Organizer: 第74回日本食道学会学術集会
• [Presentation] NAC(FP)施行食道癌切除例における血清p53抗体の予後因子としての意義. (2020)
  • Author(s): 鈴木 隆, 谷島 聡, 岡村明彦, 吉田直矢, 谷山裕亮, 村上 健太郎, 大倉 遊, 中島康晃, 八木浩一, 島田英昭（日本食道学会多施設研究グループ p53抗体研究）
  • Organizer: 第74回日本食道学会学術集会
• [Presentation] 食道癌における血清PD-L1 高値は予後不良因子か？. (2020)
  • Author(s): 伊藤正朗, 谷島 聡, 鈴木 隆, 大嶋陽幸, 名波竜規, 白鳥史明, 船橋公彦, 島田英昭
  • Organizer: 第120回日本外科学会定期学術集会
• [Presentation] 食道癌における治療前血清CYFRA の予後因子としての意義：p53 抗体多施設共同研究サブグループ解析から. (2020)
  • Author(s): 石岡伸規, 鈴木 隆, 谷島 聡, 渡邊雅之, 吉田直矢, 谷山裕亮, 村上健太郎, 大倉 遊, 中島康晃, 八木浩一, 福田 俊, 小川 了, 星野 敢, 國崎主税, 成宮孝祐, 新原正大, 相馬大介, 島田英昭
  • Organizer: 第120回日本外科学会定期学術集会
• [Presentation] 食道癌における治療前血清p53 抗体の予後因子としての意義．―p53 抗体多施設共同研究―. (2020)
  • Author(s): 鈴木 隆, 谷島 聡, 渡邊雅之, 吉田直矢, 谷山裕亮, 村上健太郎, 大倉 遊, 中島康晃, 八木浩一, 福田 俊, 小川 了, 星野 敢, 國崎主税, 成宮孝祐, 新原正大, 相馬大介, 島田英昭(日本食道学会推進研究：p53 抗体多施設研究グループ)
  • Organizer: 第120回日本外科学会定期学術集会
• [Presentation] 胃癌における血清NY-ESO-1抗体の予後予測因子としての有用性. (2019)
  • Author(s): 星野 敢, 鍋谷圭宏, 滝口伸浩, 郡司 久, 池田 篤, 早田浩明, 外岡 亨, 島田英昭
  • Organizer: 第17回日本消化器外科学会大会（JDDW2019）
• [Presentation] 食道扁平上皮癌における血清ミドカインの検討. (2019)
  • Author(s): 白鳥史明, 伊藤正朗, 谷島 聡, 鈴木 隆, 大嶋陽幸, 名波竜規, 船橋公彦, 島田英昭
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] Presence of serum autoantibodies against Ras-like GTPases, RalA, in patients with gastric cancer. (2019)
  • Author(s): Shimada H, Nanami T, Yajima S, Oshima Y, Ito M, Suzuki T, Funahashi K, Nabeya Y, Tagawa M, Matsushita K, Hoshino I
  • Organizer: 13th International Gastric Cancer Congres(IGCC 2019)
  • Int'l Joint Research
• [Presentation] Auto-Antibodies against Tumor Anigens Are Useful Biomarkers in Patients with Esophageal Squamous Cell Carcinoma. (2018)
  • Author(s): Shimada H
  • Organizer: 16th World Congress of the International Society for Diseases of the Esophagus(ISDE2018)
  • Int'l Joint Research
• [Presentation] 食道癌扁平上皮癌における血清SCC 抗原値の基準値と予後との関係について. (2018)
  • Author(s): 石岡伸規, 鈴木 隆, 谷島 聡, 大島陽幸, 名波竜規, 大塚由一郎, 船橋公彦, 島田英昭
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 血清SEREX 抗体を利用した消化器癌診断の工夫. (2018)
  • Author(s): 島田英昭
  • Organizer: 第104回日本消化器病学会総会
• [Presentation] p53・NY-ESO-1に対する自己抗体は食道扁平上皮癌における有用なバイオマーカーである. (2018)
  • Author(s): 島田英昭
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] 食道癌患者における血清SIRT3と予後の関連性の検討. (2018)
  • Author(s): 石岡伸規, 伊藤正朗, 白鳥史明, 吉田公彦, 大嶋陽幸, 鈴木 隆, 谷島 聡, 島田英昭, 船橋公彦
  • Organizer: 第16回日本消化器外科学会大会(JDDW2018)
• [Presentation] Prognostic significance of serum p53 autoantibodies in the patients with pT1N0 esophageal carcinoma. (2017)
  • Author(s): Ishioka Nobuki, Suzuki Takashi, Nanami Tatsuki, Oshima Yoko, Yajima Satoshi, Funahashi Kimihiko, Kaneko Hironori, Shimada Hideaki
  • Organizer: IASGO-CME Advanced Post-Graduate Course in Yokohama 2017
  • Int'l Joint Research
• [Presentation] A panel of serum autoantibodies in Japanese patients with hepatocellular carcinoma. (2017)
  • Author(s): Okada Rei, Shimada Hideaki, Tagawa Masatoshi, Otsuka Yuichiro, Kaneko Hironori
  • Organizer: IASGO-CME Advanced Post-Graduate Course in Yokohama 2017
  • Int'l Joint Research
• [Presentation] 新たに開発したELISA による血清midkine 値測定の食道扁平上皮癌における意義. (2017)
  • Author(s): 白鳥史明, 島田英昭, 谷島 聡, 鈴木 隆, 大嶋陽幸, 名波竜規, 伊藤正朗, 金子弘真
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 血清自己抗体による癌診断～p53抗体と新しい自己抗体マーカーについて～. (2017)
  • Author(s): 島田英昭
  • Organizer: 第55回日本癌治療学会学術集会
• [Presentation] 血清抗p53抗体が陰性化した食道癌切除例の５年経過. (2016)
  • Author(s): 高地良介, 島田英昭, 酒井隆光, 松本 悠, 長嶋康雄, 名波竜規, 鈴木 隆, 大嶋陽幸, 谷島 聡, 栃木直文, 渋谷和俊, 鷲澤尚宏, 金子弘真
  • Organizer: 第78回日本臨床外科学会総会
  • Place of Presentation: グランドプリンスホテル新高輪国際館パミール(東京都港区)
  • Year and Date: 2016-11-24
• [Presentation] 消化管癌における血清p53抗体の有用性と今後の展望. (2016)
  • Author(s): 谷島 聡, 島田英昭, 鈴木 隆, 大嶋陽幸, 名波竜規, 鈴木孝之, 牛込充則, 小池淳一, 船橋公彦, 金子弘真
  • Organizer: 第14回日本消化器外科学会大会（JDDW2016）
  • Place of Presentation: 神戸コンベンションセンター（兵庫県神戸市）
  • Year and Date: 2016-11-05
• [Presentation] Is Tissue Microarray Appropriate to Evaluate NY-ESO-1 Antigen Expression in Patients with Gastric Cancer? -Comparative Study with Serum NY-ESO-1 antibodies-. (2016)
  • Author(s): Yajima S, Shimada H, Suzuki Takashi, Nanami T, Oshima Y, Ito M, Nemoto T, Kaneko H
  • Organizer: 第40回国際外科学会世界総会(ICS Kyoto 2016)
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-10-25
  • Int'l Joint Research
• [Presentation] Useful serum biomarkers in pretreatment staging of esophageal cancer. (2016)
  • Author(s): Shimada H, Yajima S, Suzuki Takashi, Oshima Y, Nanami T, Shiratori F, Kaneko H
  • Organizer: The 15th World Congress of the International Society for Diseases of the Esophagus(ISDE 2016)
  • Place of Presentation: Singapore(Singapore)
  • Year and Date: 2016-09-20
  • Int'l Joint Research
• [Presentation] Serum p53-antibody positive esophageal Squamous cell carcinoma had a low sensitivity to chemotherapy. (2016)
  • Author(s): Yajima S, Shimada H, Suzuki Takashi, Nanami T, Oshima Y, Ito M, Nemoto T, Kaneko H
  • Organizer: The 15th World Congress of the International Society for Diseases of the Esophagus(ISDE 2016)
  • Place of Presentation: Singapore(Singapore)
  • Year and Date: 2016-09-19
  • Int'l Joint Research
• [Presentation] 食道癌術前化学療法症例において血清p53抗体は治療抵抗性と関連するか? (2016)
  • Author(s): 谷島 聡, 鈴木 隆, 白鳥 史明, 酒井 隆光, 名波 竜規, 大嶋 陽幸, 鷲澤 尚宏, 根本 哲生, 島田 英昭, 金子 弘真
  • Organizer: 第71回日本消化器外科学会総会
  • Place of Presentation: アスティとくしま（徳島県徳島市）
  • Year and Date: 2016-07-16
• [Presentation] 胃癌における血清NY-ESO-1 抗体と組織アレイを用いた臨床病理学的検討. (2016)
  • Author(s): 谷島 聡, 島田英昭, 伊藤正朗, 白鳥史明, 竹山照明, 鈴木隆, 名波竜規, 大嶋陽幸, 鷲澤尚宏, 根本哲生, 金子弘真
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: リーガロイヤルホテル大阪(大阪府大阪市)
  • Year and Date: 2016-04-15
• [Presentation] 食道癌・胃癌における新規自己抗体である血清RalA 抗体の解析. (2016)
  • Author(s): 名波竜規, 島田英昭, 白鳥史明, 松本 悠, 三浦康之, 竹山照明, 鈴木 隆, 大嶋陽幸, 谷島 聡, 鷲澤尚宏, 根本哲生, 金子弘真
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: リーガロイヤルホテル大阪(大阪府大阪市)
  • Year and Date: 2016-04-15