Novel biomarker analysis predicting efficacy of immune checkpoint inhibitors

• Project/Area Number: 16K10687
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory surgery
• Research Institution: Fukushima Medical University
• Principal Investigator: SUZUKI HIROYUKI 福島県立医科大学, 医学部, 教授 (30322340)
• Research Collaborator: SHIO yutaka ; HASEGAWA takeo ; OKABE naoyuki ; MUTO satoshi ; HUKUHARA mitsuro ; YAMAURA takumi ; OZAKI yuki (OWADA yuki) ; WATANABE masayuki ; TAKAGI hironori
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: がん免疫 / 免疫療法 / 免疫チェックポイント阻害薬 / バイオマーカー / 肺癌 / Tumor mutation burden / PD-L1 / 腫瘍浸潤リンパ球 / がん免疫療法 / 免疫チェックポイント

Outline of Final Research Achievements

We analyzed whole exome sequencing for over 200 cases of patients with non-small cell lung cancer specimen by using next generation sequencing technique to look at the predictive biomarkers for immune checkpoint inhibitors. And relationship among tumor mutation burden, PD-L1 expression, tumor infiltrating lymphocytes and several specific gene alterations were studied. We found no clear correlations among those parameters, therefor we proposed combination analysis by using those parameters. Furthermore, we found the novel findings that the amount of tumor mutation burden strongly correlated with prognosis of patinets with non small cell lung cancer.

Academic Significance and Societal Importance of the Research Achievements

免疫チェックポイント阻害薬のバイオマーカーの抽出は症例の選択や医療経済的にも重要な課題である．今回の我々の検討結果の意義は単独では十分ではない個々のパラメータを複合的に解析することでより効果的なバイオマーカーとなることを明らかにした点にある．さらに，腫瘍の遺伝子変異数が肺癌の予後に関連するという結果は今後拡大されるであろう周術期での免疫チェックポイント阻害薬の治療選択を考慮するうえで，重要な基礎的知見となるものと考えている．

Research Products

• [Int'l Joint Research] University of Miami/South Western University(米国)
• [Int'l Joint Research] Gustave Roussy cancer center(フランス)
• [Journal Article] Prognostic impact of serum transthyretin in patients with non-small cell lung cancer (2019)
  • Author(s): Shimura Tatsuo、Shibata Masahiko、Inoue Takuya、Owada-Ozaki Yuki、Yamaura Takumi、Muto Satoshi、Hasegawa Takeo、Shio Yutaka、Suzuki Hiroyuki
  • Journal Title: Molecular and Clinical Oncology Volume: 10 Pages: 597-604
  • DOI: 10.3892/mco.2019.1837
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Impact of Tumor Mutation Burden in Patients With Completely Resected Non-Small Cell Lung Cancer: Brief Report (2018)
  • Author(s): Owada-Ozaki Yuki、Muto Satoshi、Takagi Hironori、Inoue Takuya、Watanabe Yuzuru、Fukuhara Mitsuro、Yamaura Takumi、Okabe Naoyuki、Matsumura Yuki、Hasegawa Takeo、Ohsugi Jun、Hoshino Mika、Shio Yutaka、Nanamiya Hideaki、Imai Jun-ichi、Isogai Takao、Watanabe Shinya、Suzuki Hiroyuki
  • Journal Title: Journal of Thoracic Oncology Volume: 13 Issue: 8 Pages: 1217-1221
  • DOI: 10.1016/j.jtho.2018.04.003
  • Peer Reviewed
• [Journal Article] VV-ECMO during subsequent segmentectomy after right pneumonectomy (2018)
  • Author(s): Owada-Ozaki Yuki、Matsumura Yuki、Suzuki Hiroyuki
  • Journal Title: Journal of Surgical Case Reports Volume: 2018 Issue: 8 Pages: 213-213
  • DOI: 10.1093/jscr/rjy213
  • Peer Reviewed / Open Access
• [Journal Article] Significance of testing for TP53 gene mutations in lung adenocarcinoma using targeted gene sequencing (2018)
  • Author(s): Matsumura Yuki、Owada-Ozaki Yuki、Suzuki Hiroyuki
  • Journal Title: Journal of Thoracic Disease Volume: 10 Issue: S33 Pages: S4147-S4150
  • DOI: 10.21037/jtd.2018.10.66
  • Peer Reviewed / Open Access
• [Journal Article] Pseudoprogression and Rapid Response to Pembrolizumab in a Patient with Advanced Lung Adenocarcinoma with Loss of Epidermal Growth Factor Receptor Gene Mutation after Tyrosine Kinase Inhibitor Therapy (2018)
  • Author(s): Yamaura Takumi、Suzuki Hiroyuki
  • Journal Title: Journal of Thoracic Oncology Volume: 13 Issue: 10 Pages: e209-e210
  • DOI: 10.1016/j.jtho.2018.05.021
  • Peer Reviewed
• [Journal Article] Biomarkers in Immuno-Oncology - Correlation between Gut Microbiome Composition and the Effects of Immune Checkpoint Inhibitors (2018)
  • Author(s): Owada-Ozaki Y, Nishiyama K, Kobayashi T, Suzutani T, Suzuki H.
  • Journal Title: Gan To Kagaku Ryoho. Volume: 45 Pages: 1234-1237
• [Journal Article] Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy. (2018)
  • Author(s): Saito M, Suzuki H, Kono K, Takenoshita S, Kohno T.
  • Journal Title: Surg Today Volume: 48 Issue: 1 Pages: 1-8
  • DOI: 10.1007/s00595-017-1497-7
  • Peer Reviewed / Open Access
• [Journal Article] Family with sequence similarity 83, member B is a predictor of poor prognosis and a potential therapeutic target for lung adenocarcinoma expressing wild-type epidermal growth factor receptor. (2018)
  • Author(s): Yamaura T, Ezaki J, Okabe N, Takagi H, Ozaki Y, Inoue T, Watanabe Y, Fukuhara M, Muto S, Matsumura Y, Hasegawa T, Hoshino M, Osugi J, Shio Y, Waguri S, Tamura H, Imai JI, Ito E, Yanagisawa Y, Honma R, Watanabe S, Suzuki H.
  • Journal Title: Oncology Letters Volume: 15 Pages: 1549-1558
  • DOI: 10.3892/ol.2017.7517
  • Peer Reviewed / Open Access
• [Journal Article] Expression of Notch1 and Numb in small cell lung cancer. (2017)
  • Author(s): Kikuchi H, Sakakibara-Konishi J, Furuta M, Yokouchi H, Nishihara H, Yamazaki S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Takamura K, Kojima T, Harada T, Higuchi M, Honjo O, Minami Y, Watanabe N, Oizumi S, Suzuki H, Ishida T, Dosaka-Akita H, Isobe H, Munakata M, Nishimura M.
  • Journal Title: Oncotarget Volume: 8 Issue: 6 Pages: 10348-10358
  • DOI: 10.18632/oncotarget.14411
  • NAID: 120006219939
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and tolerability of nanoparticle albumin-bound paclitaxel in combination with carboplatin as a late-phase chemotherapy for recurrent and advanced non-small-cell lung cancer: A multi-center study of the Fukushima lung cancer association group of surgeons. (2017)
  • Author(s): Higuchi M, Takagi H, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Muto S, Okabe N, Matsumura Y, Hasegawa T, Yonechi A, Osugi J, Hoshino M, Shio Y, Fujiu K, Kanno R, Ohishi A, Suzuki H, Gotoh M.
  • Journal Title: Oncol Lett Volume: 13 Issue: 6 Pages: 4315-4321
  • DOI: 10.3892/ol.2017.5998
  • Peer Reviewed / Open Access
• [Journal Article] Serum Nitric Oxide as a Predictive Biomarker for Bevacizumab in Non-small Cell Lung Cancer Patients. (2017)
  • Author(s): Muto S, Takagi H, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Okabe N, Matsumura Y, Hasegawa T, Osugi J, Hoshino M, Higuchi M, Shio Y, Suzuki H.
  • Journal Title: Anticancer Res Volume: 37 Issue: 6 Pages: 3169-3174
  • DOI: 10.21873/anticanres.11676
  • Peer Reviewed
• [Journal Article] Clinical and pathological aspects of microscopic thymoma with myasthenia gravis and review of published reports. (2017)
  • Author(s): Fukuhara M, Higuchi M, Owada Y, Inoue T, Watanabe Y, Yamaura T, Muto S, Hasegawa T, Suzuki H.
  • Journal Title: Journal of Thoracic Disease Volume: 9 Issue: 6 Pages: 1592-1597
  • DOI: 10.21037/jtd.2017.05.22
  • Peer Reviewed / Open Access
• [Journal Article] Current status and future prospects of PET/CT in NSCLC treated with checkpoint-based immunotherapy. (2017)
  • Author(s): Higuchi M, Nemoto T, Matsuida H, Oshibe I, Soeta N, Takeshige T, Saito T, Suzuki H.
  • Journal Title: J Rare Dis Res Treat Volume: 2 Pages: 48-54
  • Peer Reviewed / Open Access
• [Journal Article] 肺がんに対する免疫療法の歴史とがんワクチン療法. (2017)
  • Author(s): 鈴木弘行, 髙木玄教, 大和田有紀, 渡邊 譲, 井上卓哉, 福原光朗, 山浦 匠, 武藤哲史, 岡部直行, 長谷川剛生, 塩 豊.
  • Journal Title: 癌と化学療法 Volume: 44 Pages: 646-649
• [Journal Article] 非小細胞肺癌における免疫チェックポイント阻害薬の新たなバイオマーカー抽出の可能性. (2017)
  • Author(s): 大和田有紀, 井上卓哉, 渡邊 譲, 福原光朗, 山浦 匠, 武藤哲史, 松村勇輝, 長谷川剛生, 田中大輔, 菅野 亮, 伊藤恵美, 七宮英晃, 今井順一, 磯貝隆夫, 渡辺慎哉, 鈴木弘行.
  • Journal Title: 癌と化学療法 Volume: 44 Pages: 763-766
• [Journal Article] Texture Analysis and Synthesis of Malignant and Benign Mediastinal Lymph Nodes in Patients with Lung Cancer on Computed Tomography. (2017)
  • Author(s): Pham TD, Watanabe Y, Higuchi M, Suzuki H.
  • Journal Title: Sci Rep. Volume: 7 Issue: 1 Pages: 43209-43209
  • DOI: 10.1038/srep43209
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Immunohistochemical profiling of receptor tyrosine kinases, MED12, and TGF-βRII of surgically resected small cell lung cancer, and the potential of c-kit as a prognostic marker (2016)
  • Author(s): Yokouchi H, Nishihara H, Harada T, Ishida T, Yamazaki S, Kikuchi H, Oizumi S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Takamura K, Kojima T, Higuchi M, Honjo O, Minami Y, Watanabe N, Goto A, Suzuki H, Dosaka-Akita H, Isobe H, Nishimura M, Munakata M
  • Journal Title: Oncotarget Volume: Dec 31 Issue: 24 Pages: 39711-39726
  • DOI: 10.18632/oncotarget.14410
  • Peer Reviewed / Open Access
• [Journal Article] FDG-PET in the evaluation of response to nivolumab in recurrent non-small-cell lung cancer. (2016)
  • Author(s): Higuchi M, Owada Y, Inoue T, Watanabe Y, Yamaura T, Fukuhara M, Hasegawa T, Suzuki H.
  • Journal Title: World J Surg Oncol. Volume: 14 Issue: 1 Pages: 238-238
  • DOI: 10.1186/s12957-016-0998-y
  • Peer Reviewed / Open Access
• [Journal Article] Revisiting of cancer vaccine?-Specific immunotherapy comes to field with the biomarker. (2016)
  • Author(s): Owada Y, Muto S, Hasegawa T, Higuchi M, Suzuki H.
  • Journal Title: Ann Transl Med. Volume: 4 Issue: 9 Pages: 179-179
  • DOI: 10.21037/atm.2016.04.17
  • Peer Reviewed / Open Access
• [Journal Article] Epidermal growth factor receptor gene mutation as risk factor for recurrence in patients with surgically resected lung adenocarcinoma: a matched-pair analysis. (2016)
  • Author(s): Matsumura Y, Owada Y, Yamaura T, Muto S, Osugi J, Hoshino M, Higuchi M, Ohira T, Suzuki H, Gotoh M.
  • Journal Title: Interact Cardiovasc Thorac Surg. Volume: 23 Issue: 2 Pages: 216-222
  • DOI: 10.1093/icvts/ivw116
  • Peer Reviewed / Open Access
• [Journal Article] Ground-glass nodule in a patient with echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK)-positive lung cancer: a case report. (2016)
  • Author(s): Owada Y, Yonechi A, Higuchi M, Suzuki H.
  • Journal Title: World J Surg Oncol. Volume: 14 Issue: 1 Pages: 81-81
  • DOI: 10.1186/s12957-016-0841-5
  • Peer Reviewed / Open Access
• [Journal Article] Successful Management of Crizotinib-Induced Neutropenia in a Patient with Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer: A Case Report. (2016)
  • Author(s): Osugi J, Owada Y, Yamaura T, Muto S, Okabe N, Matsumura Y, Higuchi M, Suzuki H, Gotoh M.
  • Journal Title: Case Rep Oncol. Volume: 9 Issue: 1 Pages: 51-55
  • DOI: 10.1159/000443662
  • Peer Reviewed / Open Access
• [Journal Article] Role of PET/Computed Tomography in Radiofrequency Ablation for Malignant Pulmonary Tumors. (2016)
  • Author(s): Higuchi M, Suzuki H, Gotoh M.
  • Journal Title: PET Clin, Volume: 11 Issue: 1 Pages: 47-55
  • DOI: 10.1016/j.cpet.2015.08.002
  • Peer Reviewed
• [Journal Article] Analysis of chromosome translocation frequency after a single CT scan in adults (2016)
  • Author(s): Yu Abe, Tomisato Miura, Mitsuaki A. Yoshida, et al.
  • Journal Title: Journal of Radiation Research, Volume: 57 Issue: 3 Pages: 1-7
  • DOI: 10.1093/jrr/rrv090
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 福島県における非小細胞肺癌の遺伝子検査の現状 ALK陽性肺癌における診断と治療に関するアンケート結果から． (2016)
  • Author(s): 峯村浩之, 横内 浩, 金沢賢也, 石田 卓, 藤生浩一, 長谷衣佐乃, 安藤真弘, 大杉純, 樋口光徳, 鈴木弘行, 山縣俊介, 松村輔二, 米地 敦, 高瀬裕子, 勝浦 豊, 大石明雄, 棟方 充．
  • Journal Title: 福島医学雑誌 Volume: 66 Pages: 76-83
  • NAID: 40020907482
  • Peer Reviewed
• [Presentation] Neutrophil-lymphocyte-ratio to complement the prediction ability of PD-L1 expression for outcomes in patients with advanced non-small cell lung cancer treated with PD-1/PD-L1 inhibitors. (2018)
  • Author(s): Diana Saravia, Naoyuki Okabe, Wungki Park, Deukwoo Kwon, Laura Mezquita, Young Kwang Chae, Raja Mudad, Mohammad Jahanzeb, Benjamin Besse, Hiroyuki Suzuki, Gilberto Lopes.
  • Organizer: ASCO Annual Meeting.
  • Int'l Joint Research
• [Presentation] Predicting outcomes of advanced non-small cell lung cancer patients treated with PD-1/PDL-1 inhibitors: Independent international validation of the iSEND model. (2018)
  • Author(s): Wungki Park, Laura Mezquita, Naoyuki Okabe, Deukwoo Kwon, Diana Saravia, Young Kwang Chae, Amrita Desai, David Planchard, Caroline Caramella, Raja Mudad, Mohammad Jahanzeb, Hiroyuki Suzuki, Benjamin Besse, Gilberto Lopes.
  • Organizer: ASCO Annual Meeting
  • Int'l Joint Research
• [Presentation] Neutrophil-to-Lymphocyte Ratio Complements the Prognostic Ability of PD-L1 in Non-Small Cell Lung Cancer Treated with PD-1/PD-L1 Inhibitors. (2018)
  • Author(s): Diana Saravia, Sarita Agte, Naoyuki Okabe, Wungki Park, Deukwoo Kwon, Raja Mudad, Hiroyuki Suzuki, Young Kwang Chae, Michael S Oh, Ashkon Rahbari, Gilberto Lopes.
  • Organizer: 19th World Conference on Lung Cancer.
  • Int'l Joint Research
• [Presentation] Predictive Value of Computed Tomography Characteristics for Nivolumab Response in Pretreated Non-Small Cell Lung Cancer. (2018)
  • Author(s): Hisao Imai, Hiroyuki Minemura, Hiroshi Moriya, Tomohide Sugiyama, Yutaka Yamada, Mitsunori Higuchi, Kyoichi Kaira, Yuki Ozaki, Kenya Kanazawa, Hiroshi Yokouchi, Takashi Kasai, Takayuki Kaburagi, Hiroyuki Suzuki, Koichi Minato, Yoko Shibata.
  • Organizer: 19th World Conference on Lung Cancer.
  • Int'l Joint Research
• [Presentation] 非小細胞肺癌における免疫療法の進歩 (2018)
  • Author(s): 鈴木弘行
  • Organizer: 第61回関西胸部外科学会学術集会
  • Invited
• [Presentation] これだけは知っておきたい腫瘍免疫のエッセンス～最新の免疫療法の知見も含めて～. (2018)
  • Author(s): 鈴木弘行
  • Organizer: 第178回日本胸部外科学会関東甲信越地方会
  • Invited
• [Presentation] 非小細胞肺癌における腫瘍浸潤リンパ球の臨床的意義. (2018)
  • Author(s): 尾崎有紀, 井上卓哉, 福原光朗, 山浦匠, 武藤哲史, 長谷川剛生, 塩豊, 田中大輔, 菅野亮, 伊藤恵美, 七宮英晃, 今井順一, 磯貝隆夫, 渡辺慎哉, 鈴木弘行.
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] Clinical impact of 22C3 PD-L1 expression in non-small cell lung cancer. (2018)
  • Author(s): Naoyuki Okabe, Hironori Takagi, Hiroyuki Suzuki.
  • Organizer: 2018 ASCO-SITC Clinical Immuno-Oncology Symposium.
  • Int'l Joint Research
• [Presentation] Correlation of β-catenin expression in non-small cell lung cancer to prognosis and CD8 positive cells infiltration. (2018)
  • Author(s): Satoshi Muto, Yuki Ozaki, Takuya Inoue, Takumi Yamaura, Mitsuro Fukuhara, Takeo Hasegawa, Yutaka Shio, Hiroyuki Suzuki.
  • Organizer: 2018 ASCO-SITC Clinical Immuno-Oncology Symposium
  • Int'l Joint Research
• [Presentation] Comprehensive genomic analysis with immunological parameters to obtain the biomarkers for immune checkpoint inhibitors (ICIs) in Non-Small Cell Lung Cancer (NSCLC) (2017)
  • Author(s): Yuki Owada, Satoshi Muto, Hironori Takagi, Takuya Inoue, Yuzuru Watanabe, Takumi Yamaura, Mitsuro Fukuhara, Naoyuki Okabe, Yuki Matsumura, Takeo Hasegawa, Daisuke Tanaka, Emi Ito, Hideaki Nanamiya, Jun-ichi Imai, Takao Isogai, Shinya Watanabe, Hiroyuki Suzuki
  • Organizer: ASCO-SITC Clinical Immuno-Oncology Symposium
  • Place of Presentation: Orlando, FL (USA)
  • Year and Date: 2017-02-23
  • Int'l Joint Research
• [Presentation] Discussant (Immuno-Oncology: Novel Biomarker Candidates) (2017)
  • Author(s): Hiroyuki Suzuki
  • Organizer: IASLC 18th World Conference on Lung Cancer.
  • Int'l Joint Research / Invited
• [Presentation] 当院における非小細胞肺癌に対するNivolumabの使用経験 (2016)
  • Author(s): 岡部直行, 高木玄教, 穴沢予識, 鈴木弘行.
  • Organizer: 第57 回日本肺癌学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-12-19
• [Presentation] 非小細胞肺癌に対する肺摘除術と肺機能温存手術の術後成績の比較 (2016)
  • Author(s): 樋口光徳, 大和田有紀, 井上卓哉, 渡邊 譲, 山浦 匠, 福原光朗, 武藤哲史, 長谷川剛生, 鈴木弘行.
  • Organizer: 第57 回日本肺癌学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-12-19
• [Presentation] 肺腺癌におけるFAM83Bの機能解析 (2016)
  • Author(s): 山浦 匠, 岡部直行, 大和田有紀, 井上卓哉, 渡邊 譲, 福原光朗, 長谷川剛生, 樋口光徳, 江崎淳二, 和栗 聡, 磯貝隆夫, 渡辺慎哉, 鈴木弘行.
  • Organizer: 第57 回日本肺癌学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-12-19
• [Presentation] 小細胞肺癌におけるNotch1、Numbに関する検討 (2016)
  • Author(s): 菊池 創, 榊原 純, 横内 浩, 西原広史, 浦本秀隆, 原田眞雄, 山崎成夫, 秋江研志, 菅谷文子, 藤田結花, 荻 喬博, 小島哲弥, 原田敏之, 樋口光徳, 本庄 統, 南 幸範, 渡部直己, 鈴木弘行, 棟方 充, 西村正治, 北海道肺癌臨床研究会
  • Organizer: 第57 回日本肺癌学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-12-19
• [Presentation] 肺癌の縦隔リンパ節転移に対するPET/CTの有用性の検討 (2016)
  • Author(s): 渡邊 譲, 上野哲史, 大和田有紀, 井上卓哉, 福原光朗, 山浦 匠, 長谷川剛生, 樋口光徳, 鈴木弘行.
  • Organizer: 第57 回日本肺癌学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-12-19
• [Presentation] NSCLCにおける分子免疫プロファイル解析：免疫チェックポイント阻害薬のバイオマーカー抽出の可能性 (2016)
  • Author(s): 大和田有紀, 井上卓哉, 渡邊 譲, 福原光朗, 山浦 匠, 武藤哲史, 松村勇輝, 長谷川剛生, 樋口光徳, 七宮英晃, 磯貝隆夫, 渡辺慎哉, 鈴木弘行.
  • Organizer: 第57 回日本肺癌学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-12-19
• [Presentation] 免疫療法の基礎を学ぶ 従来型免疫療法と免疫チェックポイント阻害薬 肺がんに対するがんワクチン療法の現状と展望 (2016)
  • Author(s): 鈴木弘行, 大和田有紀, 井上卓哉, 渡邊 譲, 福原 朗, 山浦 匠, 武藤哲史, 松村勇輝, 長谷川剛生, 大杉 純, 星野実加, 樋口光徳.
  • Organizer: 第57 回日本肺癌学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2016-12-19
• [Presentation] 肺がんのバイオマーカー探求 非小細胞肺癌における免疫チェックポイント阻害薬の新たなバイオマーカー抽出の可能性 (2016)
  • Author(s): 大和田有紀, 井上卓哉, 渡邊 譲, 福原光朗, 山浦 匠, 武藤哲史, 松村勇輝, 長谷川剛生, 樋口光徳, 七宮英晃, 今井順一, 磯貝隆夫, 渡辺慎哉, 和栗 聡, 鈴木弘行.
  • Organizer: 第54回日本癌治療学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-20
• [Presentation] 肺腺癌全手術例のEGFR遺伝子変異を検索すると何が分かるか? (2016)
  • Author(s): 松村勇輝, 大和田有紀, 山浦 匠, 武藤哲史, 星野実加, 大杉 純, 樋口光徳, 鈴木弘行, 後藤満一.
  • Organizer: 第33回日本呼吸器外科学会総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-05-12
• [Presentation] 肺腺癌におけるFAM83Bが増殖シグナルに及ぼす影響についての検討 (2016)
  • Author(s): 山浦 匠, 岡部直行, 高木玄教, 大和田有紀, 井上卓哉, 渡邊 譲, 福原光朗, 武藤哲史, 松村勇輝, 長谷川剛生, 米地 敦, 星野実加, 大杉 純, 樋口光徳, 江崎淳二, 和栗 聡, 鈴木弘行
  • Organizer: 第33回日本呼吸器外科学会総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-05-12
• [Presentation] 当科における胸腺癌症例に対する外科治療と術後成績 (2016)
  • Author(s): 樋口光徳, 大和田有紀, 福原光朗, 山浦 匠, 武藤哲史, 松村勇輝, 大杉 純, 星野実加, 鈴木弘行.
  • Organizer: 第33回日本呼吸器外科学会総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-05-12
• [Presentation] 高齢者肺癌に対する外科治療成績と臨床的特徴の検討―福島県多施設共同後向き調査試験― (2016)
  • Author(s): 大和田有紀, 山浦 匠, 福原光朗, 武藤哲史, 松村勇輝, 大杉 純, 星野実加, 樋口光徳, 高木玄教, 長谷川剛生, 藤生浩一, 渡邊 譲, 米地 敦, 岡部直行, 塩 豊, 井上卓哉, 管野隆三, 鈴木弘行.
  • Organizer: 第33回日本呼吸器外科学会総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-05-12
• [Presentation] 呼吸器外科における次世代シークエンサーを用いた肺癌ゲノム・遺伝子解析 (2016)
  • Author(s): 松村勇輝, 樋口光徳, 大和田有紀, 七宮英晃, 和栗 聡, 渡辺慎哉, 磯貝隆夫, 鈴木弘行, 竹之下誠一, 後藤満一.
  • Organizer: 第33回日本呼吸器外科学会総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-05-12
• [Presentation] 特発性間質性肺炎に対する外科的肺生検の意義 (2016)
  • Author(s): 星野実加, 大和田有紀, 山浦 匠, 松村勇輝, 大杉 純, 樋口光徳, 鈴木弘行
  • Organizer: 第33回日本呼吸器外科学会総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-05-12
• [Presentation] Functional analysis of family with sequence similarity 83, member B in lung adenocarcinoma. (2016)
  • Author(s): Takumi Yamaura, Naoyuki Okabe, Hironori Takagi， Yuki Owada, Takuya Inoue, Yuzuru Watanabe, Mitsuro Fukuhara, Satoshi Muto, Yuki Matsumura, Takeo Hasegawa, Atsushi Yonechi, Mika Hoshino, Jun Osugi, Mitsunori Higuchi, Junji Ezaki，Sathoshi Waguri， Hiroyuki Suzuki.
  • Organizer: AACR Annual Meeting 2016
  • Place of Presentation: New Orleans, Louisiana (USA)
  • Year and Date: 2016-04-16
  • Int'l Joint Research
• [Presentation] 高齢者肺癌切除例の他病死も含む予後予測因子としてのGlasgow prognostic scoreの有用性の検討 (2016)
  • Author(s): 大杉 純, 大和田有紀, 渡辺 譲, 井上卓哉, 山浦 匠, 福原光朗, 武藤哲史, 岡部直行, 松村勇輝, 長谷川剛生, 米地 敦, 星野実加, 樋口光徳, 塩 豊, 鈴木弘行.
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-04-14
• [Presentation] 福島県立医大における肺癌ゲノム解析プロジェクト (2016)
  • Author(s): 大和田有紀, 松村勇輝, 山浦 匠, 武藤哲史, 大杉 純, 星野実加, 樋口光徳, 田中大輔, 七宮英晃, 今井順一, 伊藤恵美, 和栗 聡, 渡辺慎哉, 磯貝隆夫, 竹之下誠一, 鈴木弘行, 後藤満一.
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-04-14
• [Presentation] 肺腺癌におけるFAM83Bが増殖シグナルに及ぼす影響についての検討 (2016)
  • Author(s): 山浦 匠, 岡部直行, 大和田有紀, 武藤哲史, 松村勇輝, 大杉 純, 星野実加, 樋口光徳, 江崎淳二, 和栗 聡, 鈴木弘行.
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-04-14
• [Presentation] 術中胸腔洗浄細胞診陽性肺癌の臨床的検討 (2016)
  • Author(s): 星野実加, 大和田有紀, 山浦 匠, 松村勇輝, 大杉 純, 樋口光徳, 鈴木弘行.
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-04-14
• [Presentation] 胸腺上皮性腫瘍手術症例の臨床的特徴と術後成績 (2016)
  • Author(s): 樋口光徳, 大和田有紀, 福原光朗, 山浦 匠, 武藤哲史, 松村勇輝, 大杉 純, 星野実加, 鈴木弘行.
  • Organizer: 第116回日本外科学会定期学術集会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-04-14
• [Presentation] 非小細胞肺癌根治術後再発症例に対するニボルマブの使用経験 (2016)
  • Author(s): 岡部直行, 高木玄教, 穴沢予識, 樋口光徳, 鈴木弘行.
  • Organizer: 第55回日本肺癌学会東北支部会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
• [Presentation] 福島県立医大における肺癌ゲノム解析プロジェクト (2016)
  • Author(s): 大和田有紀, 松村勇輝, 鈴木弘行, 七宮英晃, 渡辺慎哉, 磯貝隆夫.
  • Organizer: 福島医学会第457回学術研究集会
  • Place of Presentation: 福島県立医科大学（福島県福島市）
• [Remarks] 福島県立医科大学 呼吸器外科学講座ホームページ
  • URL: https://hirosquirrel.wixsite.com/fukushima-chestsurg/2017
• [Patent(Industrial Property Rights)] 肺癌の予後バイオマーカー (2018)
  • Inventor(s): 鈴木弘行，他
  • Industrial Property Rights Holder: 鈴木弘行，他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018