| Project/Area Number |
16K10689
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中島 裕康 北里大学, 医学部, 助教 (30769831)
内藤 雅仁 北里大学, 医学部, 助教 (50648730)
三窪 将史 北里大学, 医学部, 助教 (90723940)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 肺腺癌 / 微乳頭構造 / 細胞株 / 転移 / 浸潤 / 微小乳頭状 / Wnt5シグナル / 肺癌 / 腺癌 / 網羅的解析 / 遺伝子異常 / タンパク発現 / 微乳頭状 / 癌 / 細胞・組織 / シグナル伝達 |
|---|
| Outline of Final Research Achievements |
Primary lung adenocarcinomas with a micropapillary pattern (MPP) are characterized by more frequent and pronounced vascular invasion, higher incidence and more advanced lymph node involvement, and poorer prognosis than papillary adenocarcinomas without an MPP. Here we established a new lung cancer cell line, named KU-Lu-MPPt3, featuring micropapillary structure from a patient with adenocarcinoma with MPP. We found some genes associated with cancer metastasis and invasion.
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| Academic Significance and Societal Importance of the Research Achievements |
新規細胞株を利用して,これまで成し得なかった解析(転移モデル動物の作成, 浸潤・転移に関与する因子の網羅解析等)が可能となり, 肺癌の早期診断や治療計画を立てる際の判断材料として有用なものとなるのみならず, 新たな分子標的治療薬や免疫療法といった新規治療開発にも寄与できる可能性が非常に高く, 社会的貢献度も高い.
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