Pathological and molecular study of lung pleomorphic carcinomas to clarify the pathogenesis and develop novel treatment strategy
Project/Area Number |
16K10699
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory surgery
|
Research Institution | Keio University |
Principal Investigator |
Hishida Tomoyuki 慶應義塾大学, 医学部(信濃町), 准教授 (40544664)
|
Research Collaborator |
KURIYAMA Shoji
NAKAGOMI Takahiro
|
Project Period (FY) |
2016-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 呼吸器外科学 / 病理学 / 腫瘍学 |
Outline of Final Research Achievements |
We performed clinicopathological and molecular study to clarify pathogenesis of lung cancer with sarcomatous component (LCSC) including pleomorphic carcinoma, which has high-grade malignancy. We reviewed our medical record and identified 23 patients who underwent resection for LCSC from 1996 to 2011. The 5-year recurrence-free survival was 56%, and 8 (35%) patients developed recurrence. Among them, 7 had recurrence within 1 year after surgery, and median post-recurrence survival was only 3 months. On the other hand, 5-year recurrence-free survivors were found in 6 (26%) patients, which suggested that LCSC might have 2 groups in terms of biological behavior; the poor outcome group as shown in previous studies and the favorable outcome group. Next, we conducted molecular analysis to clarify biological signatures in sarcomatous component, a characteristic component associating with malignant behavior of LCSC, comparing with non-sarcomatous component and non-cancerous area of each case.
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Academic Significance and Societal Importance of the Research Achievements |
多形癌に代表される「肉腫様成分を含む肺癌」は、原発性肺癌の中でも増殖が速く、他臓器やリンパ節に転移しやすい悪性度が高い腫瘍である。完全切除されても、術後再発は高頻度であり、また、現状の化学療法や放射線療法には抵抗性で、肺腺癌におけるEGFR遺伝子変異やALK融合遺伝子などの有効な治療標的も同定されていない。本研究は、難治癌である「肉腫様成分を含む肺癌」の新規治療開発の足がかりとなる基盤を構築するものであり学術的かつ社会的意義は非常に大きい。
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Genomic Characteristics of Invasive Mucinous Adenocarcinomas of the Lung and Potential Therapeutic Targets of B7-H3.2018
Author(s)
Nakagomi T, Goto T, Hirotsu Y, Shikata D, Yokoyama Y, Higuchi R, Otake S, Amemiya K, Oyama T, Mochizuki H, Omata M.
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Journal Title
Cancers (Basel)
Volume: 10
Issue: 12
Pages: 478-478
DOI
Related Report
Peer Reviewed
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[Journal Article] New therapeutic targets for pulmonary sarcomatoid carcinomas based on their genomic and phylogenetic profiles.2018
Author(s)
Nakagomi T, Goto T, Hirotsu Y, Shikata D, Yokoyama Y, Higuchi R, Amemiya K, Okimoto K, Oyama T, Mochizuki H, Omata M.
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Journal Title
Oncotarget
Volume: 9
Issue: 12
Pages: 10635-10649
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical and pathological characteristics of EGFR mutation in operable early-stage lung adenocarcinoma2017
Author(s)
Yotsukura M, Yasuda H, Shigenobu T, Kaseda K, Masai K, Hayashi Y, Hishida T, Ohtsuka T, Naoki K, Soejima K, Betsuyaku T, Asamura H
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Journal Title
Lung Cancer
Volume: 109
Pages: 45-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Genomic Profiling of Large-Cell Neuroendocrine Carcinoma of the Lung2017
Author(s)
Miyoshi T, Umemura S, Matsumura Y, Mimaki S, Tada S, Makinoshima H, Ishii G5, Udagawa H, Matsumoto S, Yoh K, Niho S, Ohmatsu H, Aokage K, Hishida T, Yoshida J, Nagai K, Goto K, Tsuboi M, Tsuchihara K.
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Journal Title
Clini Cancer Res
Volume: 23
Issue: 3
Pages: 757-765
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinicopathological significance of caveolin-1 expression by cancer-associated fibroblasts in lung adenocarcinoma2017
Author(s)
K.Shimizu, K.Kirita, K.Aokage, M.Kojima, T.Hishida, T.Kuwata, S.Fujii, A.Ochiai, K.Funai, J.Yoshida, M.Tsuboi, G.Ishii
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Journal Title
Journal of Cancer Research and Clinical Oncology
Volume: 143
Issue: 2
Pages: 321-328
DOI
Related Report
Peer Reviewed
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[Journal Article] The association of intravascular stromal cells with prognosis in high-grade neuroendocrine carcinoma of the lung2016
Author(s)
Sekihara K, Hishida T, Ikemura S, Saruwatari K, Morise M, Kuwata T, Fujii S, Kojima M, Ochiai A, Funai K, Aokage K, Yoshida J, Tsuboi M, Ishii G.
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Journal Title
J Cancer Res Clin Oncol
Volume: 142
Issue: 5
Pages: 905-912
DOI
Related Report
Peer Reviewed
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[Journal Article] Lobe-Specific Nodal Dissection for Clinical Stage I and II NSCLC: Japanese Multi-Institutional Retrospective Study Using a Propensity Score Analysis2016
Author(s)
Hishida T, Miyaoka E, Yokoi K, Tsuboi M, Asamura H, Kiura K, Takahashi K, Dosaka-Akita H, Kobayashi H, Date H, Tada H, Okumura M, Yoshino I; Japanese Joint Committee of Lung Cancer Registry.
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Journal Title
J Thorac Oncol
Volume: 11
Issue: 9
Pages: 1529-1537
DOI
Related Report
Peer Reviewed
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[Journal Article] Microenvironmental changes in the progression from adenocarcinoma in situ to minimally invasive adenocarcinoma and invasive lepidic predominant adenocarcinoma of the lung2016
Author(s)
M.Naito, K.Aokage, K.Saruwatari, K.Hisakane, T.Miyoshi, T.Hishida, J.Yoshida, S.Masato, M.Kojima, T.Kuwata, S.Fujii, A.Ochiai, Y.Sato, M.Tsuboi, G.Ishii
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Journal Title
Lung Cancer
Volume: 100
Pages: 53-62
DOI
Related Report
Peer Reviewed
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[Presentation] 臨床病期I-II 期非小細胞肺癌に対する選択的リンパ節郭清の現状 肺癌登録合同委員会第5次事業2016
Author(s)
菱田智之, 宮岡悦良, 横井香平, 坪井正博, 淺村尚生, 木浦勝行, 高橋和久, 秋田弘俊, 小林英夫, 伊達洋至, 多田弘人, 奥村明之進, 吉野一郎
Organizer
第57回日本肺癌学会学術集会
Place of Presentation
福岡国際会議場(福岡県福岡市)
Year and Date
2016-12-19
Related Report
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