| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we improved the examination method of three-dimensional (3D) thoracic duct scintigraphy by the oral administration of the radioisotope-labelled BMIPP and conducted a basic study on healthy subjects. In all cases, the thoracic duct was clearly visible and no adverse events were observed. The results of this study demonstrated the necessity to start scanning at less than 100 minutes after the administration. Compared to the effective dose of 2.8mSv / 111MBq for the intravenous administration of BMIPP, the effective dose associated with thoracic duct scintigraphy was slightly higher at 4.7mSv. Since the exposure dose to the thyroid gland and intestinal tract was relatively high, it was considered that exposure could be reduced by using an iodine block before the test or a laxative after the test. The safety and exposure dose of 3D thoracic duct scintigraphy were confirmed, and the possibility of exposure reduction was clarified.
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