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Novel Immunotherapy for Malignant Thymic Epithelial Tumors with PD1/PDL1 Signaling

Research Project

Project/Area Number 16K10705
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

INOUE Masayoshi  京都府立医科大学, 医学(系)研究科(研究院), 教授 (10379232)

Co-Investigator(Kenkyū-buntansha) 常塚 啓彰  京都府立医科大学, 医学(系)研究科(研究院), 助教 (00453100)
加藤 大志朗  京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (70315943)
阿部 かおり (一瀬かおり)  京都府立医科大学, 医学部附属病院, 研究員 (80587593)
Research Collaborator Ishihara Shunta  京都府立医科大学, 大学院医学研究科, 大学院生
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords胸腺上皮性腫瘍 / PD-L1 / 胸腺腫 / 胸腺癌
Outline of Final Research Achievements

We investigated PD-L1 expression in 66 thymic epithelial tumors. In addition to conventional visual evaluation, we performed Whole Slide Imaging (WSI), which enable an objective assessment, and analyzed their relationship. As a result, 1, WSI is available in thymoma, but not in thymic carcinoma due to its variety. 2, PD-L1 expression level is correlated with histological grade and stage in thymic epithelial tumors overall. 3, Patients with PD-L1 high expression tumors show poor prognosis in both relapse-free and overall survivals. These results suggest PD-L1 expression could be an biomarker in malignant thymic epithelial tumors.

Academic Significance and Societal Importance of the Research Achievements

本研究は比較的稀な悪性腫瘍である胸腺腫・胸腺癌における免疫チェックポイント分子の発現解析に関し,従来の免疫染色法に加えより客観的なデジタルイメージ解析を行ったもので,将来的な免疫チェックポイント阻害薬の開発と実臨床に寄与する可能性がある.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2019 2018 2017

All Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] Type AB胸腺腫19例のtype A型・B型領域別による検討2019

    • Author(s)
      石原駿太,岡田悟,常塚啓彰,井上匡美
    • Organizer
      第38回日本胸腺研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] The expression pattern of programmed death- ligand 1 according to the pathological type of malignant thymic epithelial tumor.2018

    • Author(s)
      shihara S, Okada S, Ogi H, Kodama Y, Itoh K, Marx A, Inoue M.
    • Organizer
      19th World Congress On Lung Cancer
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Whole Slide Imaging を用いた悪性胸腺上皮性腫瘍におけるPD-L1発現のデジタル解析.2018

    • Author(s)
      石原駿太,岡田悟,Alexander Marx,常塚啓彰,加藤大志朗,島田順一,井上匡美
    • Organizer
      第71回日本胸部外科学会定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Prognostic significance of PD-L1 expression in pulmonary metastasis from head and neck squamous cell carcinoma2017

    • Author(s)
      Okada S, Shimada J, Kato D, Tsunezuka H, Furuya T, Inoue M.
    • Organizer
      25th European Conference on General Thoracic Surgery
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 頭頸部扁平上皮癌肺転移におけるPD-L1発現の意義2017

    • Author(s)
      岡田悟,島田順一,加藤大志朗,常塚啓彰,古谷竜男,井上匡美.
    • Organizer
      第34回日本呼吸器外科学会総会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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