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Treatment target of hyper residual platelet reactivity in patients receiving anti platelet therapy

Research Project

Project/Area Number 16K10717
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionGifu University

Principal Investigator

Enomoto Yukiko  岐阜大学, 医学部附属病院, 講師 (20377659)

Co-Investigator(Kenkyū-buntansha) 岩間 亨  岐阜大学, 大学院医学系研究科, 教授 (20303498)
江頭 裕介  岐阜大学, 大学院医学系研究科, 助教 (50547677)
山内 圭太  岐阜大学, 医学部附属病院, 助教 (10452153)
辻本 真範  岐阜大学, 大学院医学系研究科, 非常勤講師 (70509554)
澤田 重信  岐阜大学, 医学部附属病院, 助教 (40610415)
宮居 雅文  岐阜大学, 医学部附属病院, 医員 (60613502)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords抗血小板薬 / 血小板不応症 / 抗血小板剤不応症 / 血小板凝集能 / クロピトグレル / CYP2CI9 / クロピドグレル / CYP2C19
Outline of Final Research Achievements

Our study showed that "acute stroke" is more strongly related with high residual on-treatment platelet reactivity (HRPR) on antiplatelet therapy than genetic polymorphism which is most known.
In acute stroke patients, the release of phosphorylated-heat shock protein 27 (HSP27) from thrombin-stimulated platelets is accelerated via Rac.

Academic Significance and Societal Importance of the Research Achievements

従来、不応症の主な原因は薬剤相互作用や薬物代謝酵素の遺伝子多型とされ、抗血小板薬の変更や追加投与により対処せざるを得ないと考えられていたが、急性期脳梗塞における一時的な不応症においては、血小板におけるトロンビン刺激感受性の亢進、および血小板から放出されるHeat Shock Protein 27の関与が示された。 急性期においては、トロンビン受容体拮抗薬などの併用が臨床的効果をもたらす可能性が示唆された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 Other

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Remarks (1 results)

  • [Journal Article] Rac Regulates the TRAP-Induced Release of Phosphorylated-HSP27 from Human Platelets via p38 MAP Kinase but Not JNK.2018

    • Author(s)
      Uematsu K, Enomoto Y, Onuma T, Tsujimoto M, Doi T, Matsushima-Nishiwaki R, Tokuda H, Ogura S, Iida H, Kozawa O, Iwama T.
    • Journal Title

      Cell Physiol Biochem

      Volume: 49 Issue: 4 Pages: 1523-1538

    • DOI

      10.1159/000493456

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ristocetin induces phosphorylated-HSP27 (HSPB1) release from the platelets of type 2 DM patients: Anti-platelet agent-effect on the release.2018

    • Author(s)
      Tokuda H, Kuroyanagi G, Onuma T, Enomoto Y, Doi T, Iida H, Otsuka T, Ogura S, Iwama T, Kojima K, Kozawa O.
    • Journal Title

      Biomed Rep

      Volume: 4 Pages: 365-372

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting.2018

    • Author(s)
      Tsujimoto M, Enomoto Y, Miyai M, Egashira Y, Iwama T.
    • Journal Title

      J Int Med Res

      Volume: 46 Pages: 1866-1875

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
  • [Journal Article] Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor.2017

    • Author(s)
      Onuma T, Tanabe K, Kito Y, Tsujimoto M, Uematsu K, Enomoto Y, Matsushima-Nishiwaki R, Doi T, Nagase K, Akamatsu S, Tokuda H, Ogura S, Iwama T, Kozawa O, Iida H.
    • Journal Title

      Thromb Res.

      Volume: 156 Pages: 91-100

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Remarks] 岐阜大学医学部脳神経外科

    • URL

      http://www.med.gifu-u.ac.jp/neurosurgery/

    • Related Report
      2017 Research-status Report 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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