The kinetics and role of immune cells in the ischemic stroke rats model
| Project/Area Number |
16K10721
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
Sugimoto Kana 大阪大学, 医学系研究科, 講師 (00581034)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 脳梗塞 / 磁気共鳴画像法 / 免疫細胞動態 / マクロファージ / 磁気共鳴イメージング / 細胞追跡 |
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| Outline of Final Research Achievements |
In the present study, we confirmed the transmigration of immune cells in the ischemic stroke mice model, but did not it in the ischemic stroke rats model using 11.7T MRI imaging. Next, we tried to evaluate the role of resident microglia-derived macrophage-like cells (MG-MΦ) and bone marrow-derived macrophages (BM-MΦ) in the ischemic brain. We found that MG-MΦ signature genes were highly expressed in the ischemic core in aggravated rats, while BM-MΦ signature genes were weakly expressed. These findings suggest that the distribution ratio between two macrophages may affect progress after stroke.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究から、脳梗塞巣に集積する常在性マイクログリア由来マクロファージ（MG-MΦ）及び骨髄由来の浸潤性マクロファージ（BM-MΦ）の構成比率が脳梗塞の予後を大きく左右することを明らかにした。従って、今後は脳梗塞の予後を悪化させるMG-MΦの構成比率の低下、または、MG-MΦの機能抑制をターゲットとした治療法の開発を行うことが、脳梗塞の新規治療薬の開発につながると考えている。
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Report
(5 results)
Research Products
(26 results)
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[Journal Article] Molecular mechanisms of Wischnewski spot development on gastric mucosa in fatal hypothermia: an experimental study in rats2020
Author(s)
Chihpin Yang, Kana Sugimoto, Yukie Murata, Yuichiro Hirata, Yu Kamakura, Yoshihisa Koyama, Yohei Miyashita, Kentaro Nakama, Kazuma Higashisaka, Kazuo Harada, Ryuichi Katada, Hiroshi Matsumoto
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 1877-1877
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The hypnotic bromovalerylurea ameliorates 6-hydroxydopamine-induced dopaminergic neuron loss while suppressing expression of interferon regulatory factors by microglia2016
Author(s)
Hiromi Higaki, Mohammed Emamussalehin Choudhury, Chisato Kawamoto, Keisuke Miyamoto, Afsana Islam, Yurika Ishii, Kazuya Miyanishi, Haruna Takeda, Naoto Seo, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano and Junya Tanaka
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Journal Title
Neurochemistry International
Volume: 99
Pages: 158-168
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Treadmill exercise ameliorates ischemia-induced brain edema while suppressing Na+/H+ exchanger 1 expression2016
Author(s)
Ryutaro Nishioka, Kana Sugimoto, Hitomi Aono, Ayano Mise, Mohammed E. Choudhury, Kazuya Miyanishi, Afsana Islam, Takahiro Fujita, Haruna Takeda, Hisaaki Takahashi, Hajime Yano, Junya Tanaka
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Journal Title
Experimental Neurology
Volume: 277
Pages: 150-161
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Molecular mechanisms of Wischnewski spot development on gastric mucosa in fatal hypothermia: an experimental study in rats2020
Author(s)
Chihpin Yang, Kana Sugimoto, Yukie Murata, Rina Gono, Yuichiro Hirata, Yohei Miyashita, Kentaro Nakama, Kazuma Higashisaka, Kazuo Harada, Ryuichi Katada, Hiroshi Matsumoto
Organizer
第97回日本生理学会大会
Related Report
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[Presentation] The spatial and time-dependent changes of various miRNAs expression in the ischemic rat brain2020
Author(s)
Kana Sugimoto, Chihpin Yang, Yukie Murata, Rina Gono, Yuichiro Hirata, Teiji Harada, Yohei Miyashita, Kazuma Higashisaka, Kazuo Harada, Ryuichi Katada, Hiroshi Matsumoto
Organizer
第97回日本生理学会大会
Related Report
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[Presentation] Development of a metabolic fingerprinting method for cause of death investigation2018
Author(s)
Kazuo Harada, Chisato Okajima, Saki Yoshida, Takuya Nakai, Kazumasa Hirata, Tokiko Ishida, Kentaro Nakama, Kana Sugimoto, Kazuma Higashisaka, Ryuichi Katada, Hiroshi Matsumoto
Organizer
24th Congress of the International Academy of Legal Medicine
Related Report
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