Alterations of neurite morphology associated with cerebral blood flow during motor recovery in patients with acute lacuna stroke
| Project/Area Number |
16K10747
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Yokota Chiaki 国立研究開発法人国立循環器病研究センター, 病院, 医長 (80300979)
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| Co-Investigator(Kenkyū-buntansha) |
小亀 浩市 国立研究開発法人国立循環器病研究センター, 研究所, 部長 (40270730)
天滿 敬 大阪薬科大学, 薬学部, 教授 (90378787)
越野 一博 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (90393206)
安野 史彦 国立研究開発法人国立長寿医療研究センター, 病院, 医長 (60373388)
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| Research Collaborator |
Ando Daisuke
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 急性ラクナ梗塞 / 脳PET / 神経微細構造 / 脳血流量 / 機能回復 / 急性期ラクナ梗塞 / diffusion tensor imaging / 神経可塑性 / PET / MRI拡散イメージング / 錐体外路 / リハビリテーション / 神経機能回復 / 神経科学 / 脳神経疾患 |
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| Outline of Final Research Achievements |
We examined alteration of neurite morphology associated with changes of cerebral blood flow (CBF) during motor recovery in patients with acute lacuna stroke. Motor recovery, neurite orientation dispersion and density imaging, and 15O-gas positron emission tomography were assessed at baseline and 3 months after stroke onset. We enrolled 16 patients (63 y.o. in average, 14 males,15 were right handed) in the present study. Significant motor recovery was confirmed at 3 months. Increased CBF in insular cortex and precentral gyrus in the left side, and right anterior cingulate cortex were observed at baseline. Significant increases of intracellular volume fraction in the left precentral gyrus and decreases of orientation dispersion index in the right cerebellar cortex were demonstrated at 3 months. In conclusion, significant alterations in microstructure in the white matter as well as CBF were demonstrated in patients with acute lacuna stroke during 3 months after stroke onset.
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| Academic Significance and Societal Importance of the Research Achievements |
実験的研究を含め、複数の研究結果より、脳梗塞発症後間もない時期は、神経可塑性が高まっていることが明らかにされている。しかし、脳梗塞後の機能回復過程における脳血流量と神経線維構築の変化に関しては明らかではない。本研究では、主幹脳動脈に狭窄性病変のないラクナ梗塞例を対象にすることで、血管狭窄に起因する血流量の影響を排除し、巧緻運動障害例を対象とすることで、日常生活を含め、利き手を用いた運動訓練効果に注目した。本研究結果より、急性期脳卒中患者に対して、急性期からの集中的な特異的動作訓練は、標的とした領域の脳血流増加と訓練継続による神経再構築が生じうることが示された。
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Binding of 11C-Pittsburgh compound-B correlated with white matter injury in hypertensive small vessel disease2017
Author(s)
Hashimoto T, Yokota C, Koshino K, Temma T, Yamazaki M, Iguchi S, Shimomura R, Uehara T, Funatsu N, Hino T, Minematsu K, Iida H, Toyoda K.
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Journal Title
Ann Nucl Med
Volume: 31
Issue: 3
Pages: 227-234
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of a school-based stroke education program on stroke-related knowledge and behaviour modification-school class based intervention study for elementary school students and parental guardians in a Japanese rural area2017
Author(s)
Kato S, Okamura T, Kuwabara K, Takekawa H, Nagao M, Umesawa M, Sugiyama D, Miyamatsu N, Hino T, Wada S, Arimizu T, Takebayashi T, Kobashi G, Hirata K, Yokota C, Minematsu K.
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Journal Title
BMJ Open
Volume: 7(12)
Issue: 12
Pages: e017632-e017632
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Reversible cerebral vasoconstriction syndrome after heart transplantation: A case report2017
Author(s)
Kumai Y, Seguchi O, Sato T, Wada K, Shiozawa M, Yokota C, Kuroda K, Nakajima S, Sato T, Yanase M, Matsumoto Y, Fukushima S, Fujita T, Kobayashi J, Fukushima N
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Journal Title
Transplantation Proceedings
Volume: 49(10)
Issue: 10
Pages: 2415-2418
DOI
Related Report
Peer Reviewed
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[Presentation] School-based stroke education using a manga for elementary schoolchildren aiming at spreading awareness of stroke: A meta-analysis.2017
Author(s)
Hino T, Yokota C, Nishimura K, Nakai M , Kato S , Kuwabara K, Takekawa T, Arimizu T , Tomari S, Wada S, Ohnishi H, Toyoda K , Okamura T , Minematsu K
Organizer
XXIII World Congress of Neurology 2017
Related Report
Int'l Joint Research
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