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Alterations of neurite morphology associated with cerebral blood flow during motor recovery in patients with acute lacuna stroke

Research Project

Project/Area Number 16K10747
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Yokota Chiaki  国立研究開発法人国立循環器病研究センター, 病院, 医長 (80300979)

Co-Investigator(Kenkyū-buntansha) 小亀 浩市  国立研究開発法人国立循環器病研究センター, 研究所, 部長 (40270730)
天滿 敬  大阪薬科大学, 薬学部, 教授 (90378787)
越野 一博  国立研究開発法人国立循環器病研究センター, 研究所, 室長 (90393206)
安野 史彦  国立研究開発法人国立長寿医療研究センター, 病院, 医長 (60373388)
Research Collaborator Ando Daisuke  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords急性ラクナ梗塞 / 脳PET / 神経微細構造 / 脳血流量 / 機能回復 / 急性期ラクナ梗塞 / diffusion tensor imaging / 神経可塑性 / PET / MRI拡散イメージング / 錐体外路 / リハビリテーション / 神経機能回復 / 神経科学 / 脳神経疾患
Outline of Final Research Achievements

We examined alteration of neurite morphology associated with changes of cerebral blood flow (CBF) during motor recovery in patients with acute lacuna stroke. Motor recovery, neurite orientation dispersion and density imaging, and 15O-gas positron emission tomography were assessed at baseline and 3 months after stroke onset. We enrolled 16 patients (63 y.o. in average, 14 males,15 were right handed) in the present study. Significant motor recovery was confirmed at 3 months. Increased CBF in insular cortex and precentral gyrus in the left side, and right anterior cingulate cortex were observed at baseline. Significant increases of intracellular volume fraction in the left precentral gyrus and decreases of orientation dispersion index in the right cerebellar cortex were demonstrated at 3 months. In conclusion, significant alterations in microstructure in the white matter as well as CBF were demonstrated in patients with acute lacuna stroke during 3 months after stroke onset.

Academic Significance and Societal Importance of the Research Achievements

実験的研究を含め、複数の研究結果より、脳梗塞発症後間もない時期は、神経可塑性が高まっていることが明らかにされている。しかし、脳梗塞後の機能回復過程における脳血流量と神経線維構築の変化に関しては明らかではない。本研究では、主幹脳動脈に狭窄性病変のないラクナ梗塞例を対象にすることで、血管狭窄に起因する血流量の影響を排除し、巧緻運動障害例を対象とすることで、日常生活を含め、利き手を用いた運動訓練効果に注目した。本研究結果より、急性期脳卒中患者に対して、急性期からの集中的な特異的動作訓練は、標的とした領域の脳血流増加と訓練継続による神経再構築が生じうることが示された。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (23 results)

All 2019 2018 2017 2016

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Open Access: 2 results) Presentation (11 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results) Book (5 results)

  • [Journal Article] Dendrite Complexity of the Posterior Cingulate Cortex as a Substrate for Recovery from Post-stroke Depression: A Pilot Study2019

    • Author(s)
      Yasuno F, Ando D, Yamamoto A, et al.
    • Journal Title

      Psychiatry Research: Neuroimaging

      Volume: 287 Pages: 49-55

    • DOI

      10.1016/j.pscychresns.2019.01.015

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delivering knowledge of stroke to parents through their children using a manga for stroke education in elementary school2017

    • Author(s)
      Ishigami A, Yokota C, Nishimura K, Ohyama S, Tomari S, Hino T, Arimizu T, Wada S, Toyoda K, Minematsu K
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 26 Issue: 2 Pages: 431-437

    • DOI

      10.1016/j.jstrokecerebrovasdis.2016.10.005

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of characteristics of stroke-associated pneumonia in Stroke Care Units in Indonesia and Japan2017

    • Author(s)
      Sari IM, Soertidewi L, Yokota C, Kikuno M, Koga M, Toyoda K
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 26 Issue: 2 Pages: 280-285

    • DOI

      10.1016/j.jstrokecerebrovasdis.2016.09.018

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Binding of 11C-Pittsburgh compound-B correlated with white matter injury in hypertensive small vessel disease2017

    • Author(s)
      Hashimoto T, Yokota C, Koshino K, Temma T, Yamazaki M, Iguchi S, Shimomura R, Uehara T, Funatsu N, Hino T, Minematsu K, Iida H, Toyoda K.
    • Journal Title

      Ann Nucl Med

      Volume: 31 Issue: 3 Pages: 227-234

    • DOI

      10.1007/s12149-017-1152-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of school-based intervention by emergency medical technicians on students and their parents: a community-based prospective study of the Akashi project2017

    • Author(s)
      Tomari S, Yokota C, Nishimura K, Hino T, Ohyama S, Arimizu T, Wada S, Ohnishi H, Toyoda K, Minematsu K
    • Journal Title

      BMJ Open

      Volume: 7(10) Issue: 10 Pages: e016780-e016780

    • DOI

      10.1136/bmjopen-2017-016780

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of a school-based stroke education program on stroke-related knowledge and behaviour modification-school class based intervention study for elementary school students and parental guardians in a Japanese rural area2017

    • Author(s)
      Kato S, Okamura T, Kuwabara K, Takekawa H, Nagao M, Umesawa M, Sugiyama D, Miyamatsu N, Hino T, Wada S, Arimizu T, Takebayashi T, Kobashi G, Hirata K, Yokota C, Minematsu K.
    • Journal Title

      BMJ Open

      Volume: 7(12) Issue: 12 Pages: e017632-e017632

    • DOI

      10.1136/bmjopen-2017-017632

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reversible cerebral vasoconstriction syndrome after heart transplantation: A case report2017

    • Author(s)
      Kumai Y, Seguchi O, Sato T, Wada K, Shiozawa M, Yokota C, Kuroda K, Nakajima S, Sato T, Yanase M, Matsumoto Y, Fukushima S, Fujita T, Kobayashi J, Fukushima N
    • Journal Title

      Transplantation Proceedings

      Volume: 49(10) Issue: 10 Pages: 2415-2418

    • DOI

      10.1016/j.transproceed.2017.10.016

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] Changes in cerebral blood flow and metabolism associated with neurite morphology after motor recovery in patients with small vessel disease2018

    • Author(s)
      Ando D, Yasuno F, Koshino K, Sato T, Yamamoto A, Odani H, Inoue M, Kazunori T, Yokota C
    • Organizer
      4th European Stroke Organisation Conference
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Increasing stroke awareness in schoolchildren and their parents and improving call-to-door time by school-based intervention by emergency medical technicians: The Akashi Project.2017

    • Author(s)
      Yokota C, Arimizu T, Tomari S, Hino T, Nishimura K, Wada S, Ohnishi H, Toyoda K, Minematsu K
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] School-based stroke education using a manga for elementary schoolchildren aiming at spreading awareness of stroke: A meta-analysis.2017

    • Author(s)
      Hino T, Yokota C, Nishimura K, Nakai M , Kato S , Kuwabara K, Takekawa T, Arimizu T , Tomari S, Wada S, Ohnishi H, Toyoda K , Okamura T , Minematsu K
    • Organizer
      XXIII World Congress of Neurology 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 究極の時間短縮戦略:若年層をターゲットにした脳卒中啓発とその効果2017

    • Author(s)
      横田千晶、峰松一夫
    • Organizer
      42回日本脳卒中学会総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 小学校教師による脳卒中授業の啓発効果:吹田プロジェクト2017

    • Author(s)
      日野天佑、横田千晶、西村邦宏、中井陸運、有水琢朗、和田晋一、泊晋哉、豊田一則、峰松一夫
    • Organizer
      第42回日本脳卒中学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 急性被殻出血の病変側による急性期脳卒中リハビリテーションの効果の違い2017

    • Author(s)
      石原稔也,横田千晶,尾谷寛隆,猪原匡史,後藤葉一,豊田一則
    • Organizer
      第42回日本脳卒中学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 脳卒中急性期リハビリテーションへの下肢装着型ロボットHALの臨床応用の可能性2017

    • Author(s)
      横田千晶, 安藤大祐, 越野一博, 山本明秀, 尾谷寛隆, 猪原匡史, 豊田一則
    • Organizer
      第4回日本心血管脳卒中学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 高血圧性細小血管障害の脳循環代謝病態2017

    • Author(s)
      横田千晶, 越野一博, 豊田一則, 峰松一夫
    • Organizer
      第60回日本脳循環代謝学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 急性期ラクナ梗塞の回復過程における脳循環代謝と神経線維密度の変化2017

    • Author(s)
      安藤大祐,越野一博,安野史彦,佐藤健朗,山本明秀,尾谷寛隆,豊田一則,横田千晶
    • Organizer
      第60回日本脳循環代謝学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Diffusion tensor imagingを用いた急性期脳卒中例への下肢装着型ロボットHAL®によるリハビリテーション効果の検討2017

    • Author(s)
      佐藤健朗,安藤大祐,越野一博,西村邦宏,中井陸運,尾谷寛隆,山本明秀,猪原匡史,豊田一則,横田千晶
    • Organizer
      第60回日本脳循環代謝学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 慢性期ラクナ梗塞での白質病変重症度別脳循環代謝の比較2016

    • Author(s)
      有水琢朗、横田千晶、越野一博、日野天佑、森田奈緒美、宮本恵宏、飯田秀博、豊田一則
    • Organizer
      第59回脳循環代謝学会
    • Place of Presentation
      徳島
    • Year and Date
      2016-11-11
    • Related Report
      2016 Research-status Report
  • [Book] 脳卒中病態学のススメ 脳卒中リハビリテーション2018

    • Author(s)
      横田千晶
    • Publisher
      南山堂
    • Related Report
      2018 Annual Research Report
  • [Book] 脳卒中病態学のススメ2018

    • Author(s)
      横田千晶
    • Total Pages
      366
    • Publisher
      南山堂、東京
    • ISBN
      9784525248512
    • Related Report
      2017 Research-status Report
  • [Book] 脳血管障害診療のエッセンス 脳血管障害の市民啓発とFAST2017

    • Author(s)
      横田千晶
    • Total Pages
      348
    • Publisher
      日本医師会、東京
    • ISBN
      9784758317788
    • Related Report
      2017 Research-status Report
  • [Book] 脳血管障害診療のエッセンス 脳血管障害の画像2017

    • Author(s)
      塩澤真之、横田千晶、峰松一夫
    • Total Pages
      348
    • Publisher
      日本医師会、東京
    • ISBN
      9784758317788
    • Related Report
      2017 Research-status Report
  • [Book] 脳卒中治療ガイドライン2015(追補2017)2017

    • Author(s)
      横田千晶、峰松一夫
    • Total Pages
      360
    • Publisher
      医学書院、東京
    • ISBN
      9784877941697
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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