| Project/Area Number |
16K10825
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SAKAI Toshinori 徳島大学, 大学院医歯薬学研究部(医学域), 准教授 (80403731)
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| Co-Investigator(Kenkyū-buntansha) |
西良 浩一 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (10304528)
高田 洋一郎 徳島大学, 大学院医歯薬学研究部(医学域), 特任准教授 (20420549)
東野 恒作 徳島大学, 大学院医歯薬学研究部(医学域), 徳島大学専門研究員 (80380129)
手束 文威 徳島大学, 大学院医歯薬学研究部(医学域), 助教 (40782470)
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 腰椎分離症 / 腰痛 / 疲労骨折 / 超音波検査 / 腰椎疲労骨折 / 解剖 / 遺伝子 / 腰椎分離すべり症 |
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| Outline of Final Research Achievements |
All the patients with terminal-stage spondylolysis had two separate arteries originating from the cranial and caudal sides that distributed to the superior and inferior articular processes, suggesting that the pars interarticularis is a posterior element containing a vascular watershed area. Extraosseous signal changes on MRI were detected in more than 90% patients before the occurrence of stress fracture in lamina (lumbar spondylolysis), which was considered similar to findings such as periosteal thickening/edema detected at the onset of stress fracture of the long bones. Although there are several limitations to this study, ESCs on MRI may be a significant finding accompanied with stress fracture in the lamina, which can be detected by ultrasonography.
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| Academic Significance and Societal Importance of the Research Achievements |
腰椎分離症の病態解明につながる研究であり，また今後の腰椎分離症患者のスポーツ現場での早期発見また治療成績の向上につながるpreliminaryな結果と考えられる．
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