| Project/Area Number |
16K10884
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Research Collaborator |
Watanabe Atuya
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 多血小板血漿 / アキレス腱 / MRI T2mapping / アキレス腱断裂 / 整形外科学 / スポーツ医学 |
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| Outline of Final Research Achievements |
Three groups were prepared to which high concentration PRP (H-PRP), low concentration PRP (L-PRP) and saline were respectively administered. Each group was administered immediately after the Achilles tendon transection surgery, and MRI and histologic and mechanical evaluation of the tendon repair site were performed 4 and 8 weeks after the operation.
The platelet count of the L-PRP and H-PRP were about 3.8 times and 12.8 times higher than that of the whole blood. MRI evaluation was used to measure T2 value. Histological evaluation was performed using Bonner scale. Mechanical evaluation was used to measure the elastic modulus and the linear stiffness. T2 value and Bonner scale were lower in the order of saline, L-PRP, H-PRP, and there was a significant difference. The elastic modulus and the linear stiffness values were higher in the order of saline, L-PRP, H-PRP.
Significant correlations were obtained between T2 values and Bonner scale, the elastic modulus and the linear stiffness.
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| Academic Significance and Societal Importance of the Research Achievements |
アキレス腱断裂は人体の中で最も多い腱断裂である。腱修復には時間がかかり、スポーツ復帰まで6-9か月かかる。適切な評価、治療による早期の社会、スポーツ復帰は社会的要請が大きい。現在、臨床で使用可能なアキレス腱断裂後の修復過程を定量的に評価する手法はない。
本研究により、修復部の平均T2 値と組織学的な修復スコア、力学的評価（弾性率及び剛性）とは有意に相関することが示され、T2 mapping が臨床で使用可能な腱修復の定量的評価法として有用である可能性を明らかにした。
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