Bone strength measurement method by finite element analysis in consideration of qualitative factor of bone collagen

Research Project

Project/Area Number	16K10886
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Chiba University
Principal Investigator	Matsuura Yusuke 千葉大学, 医学部附属病院, 助教 (60638336)
Co-Investigator(Kenkyū-buntansha)	鈴木崇根千葉大学, 大学院医学研究院, 講師 (30513072) 大鳥精司千葉大学, 大学院医学研究院, 教授 (40361430) 國吉一樹千葉大学, 大学院医学研究院, 准教授 (40375788)
Project Period (FY)	2016-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	骨強度 / 骨密度 / 骨質 / 新鮮凍結屍体 / ペントシジン / 酸化ストレス
Outline of Final Research Achievements	Bone strength is determined from bone quality and bone mass (bone density). Bone quality includes not only structural elements but also elements of collagen. In recent years, due to technological innovation, bone strength can measured using CT data. However, it did not include all elements of bone quality, and accurate bone strength measurement could not be performed. This study demonstrated that It is possible to measure more accurate by using a simulation method (finite element model). We established a finite element model that incorporates elements of collagen to create a high model
Academic Significance and Societal Importance of the Research Achievements	脆弱性骨折に伴う社会的経済的な損失は計り知れない。現在は骨密度のみの骨粗鬆症診断に依存するため、正確な骨粗鬆症の診断ができず、脆弱性骨折を来す患者があとを絶えない。正確な骨強度を測定することで、骨密度低下を伴わない骨粗鬆症を発見し、脆弱性骨折を予防できる。また、このモデルを使うことで、手術のシミュレー－ション、術式の決定に貢献でき、テーラーメイドな医療に貢献できる。