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Verification of the bioactive effect of human amnion-derived extracellular matrix-coated PLGA scaffold and its application for cartilage repair therapy.

Research Project

Project/Area Number 16K10895
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionUniversity of Toyama

Principal Investigator

NOGAMI Makiko  富山大学, 附属病院, 助教 (30750202)

Research Collaborator KIMURA tomoatsu  
SEKI shoji  
YAHARA yasuhito  
IWASAKI mami  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords軟骨再生 / 羊膜 / 生体材料 / 細胞外マトリックス / 関節病学 / 再生医学
Outline of Final Research Achievements

We develop a novel cell-free biological scaffold “ECM-PLGA” for cartilage repair therapy. ECM-PLGA contains amnion-derived extra-cellular matrix-coated on bioabsorbable PLGA scaffold. Amniotic membrane has been thought to have several biological activities such as wound healing and anti-inflammation effect. This study was carried out to verify the hypothesis, anti-inflammation effect brought by amniotic ECM support the better cartilage repair in chronic osteoarthritis. When cultured on amnion-ECM coated dishes and ECM-PLGA, human synovial fibroblasts and human macrophages showed higher production of inflammatory cytokines. Gene expression pattern showed no evidence of conversion from inflammatory macrophages to anti-inflammatory macrophages. In conclusion, no obvious anti-inflammatory effect was indicated from this study.

Academic Significance and Societal Importance of the Research Achievements

羊膜は炎症抑制・創傷治癒効果に優れるとされ、再生医療分野への応用が期待される。我々が作成したECM-PLGAは過去の動物実験で優れた軟骨修復促進効果を示したが、そのメカニズムは不明である。今回in vitro実験系でECM-PLGAが軟骨欠損に伴う関節内炎症環境における抗炎症・軟骨修復に寄与する結果を期待したが、ECM-PLGAを配した培養上清中の炎症性サイトカイン分泌が高い結果となった。引き続きECM-PLGAの生体活性に関して調査を進め軟骨修復に関わるメカニズムを明らかにし、軟骨再生治療における新たな生体移植材料としてECM-PLGAの臨床応用を目指す一助としたい。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2019 2018 2017 2016

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (8 results)

  • [Journal Article] Postoperative examination of high tibial osteotomy in Itoigawa General Hospital2018

    • Author(s)
      二川 隼人,須澤 俊,山上 亨,野上 真紀子
    • Journal Title

      The Central Japan Journal of Orthopaedic Surgery & Traumatology

      Volume: 61 Issue: 3 Pages: 531-532

    • DOI

      10.11359/chubu.2018.531

    • NAID

      130007498433

    • ISSN
      0008-9443, 1349-0885
    • Year and Date
      2018-05-01
    • Related Report
      2018 Annual Research Report
  • [Journal Article] CR型TKA術後の屈曲位外側弛緩性と膝屈曲角度との関連およびその経時的変化2018

    • Author(s)
      下条竜一,峯 隼人,野上真紀子
    • Journal Title

      JOSKAS

      Volume: 43 Pages: 386-387

    • Related Report
      2018 Annual Research Report
  • [Journal Article] 2期的両側TKAにおいて1膝目の経験は2膝目の患者満足度に貢献するか2018

    • Author(s)
      野上真紀子,下条竜一,峯 隼人,元村 拓,松下 功,平岩利仁,木村友厚
    • Journal Title

      日本人工関節学会誌

      Volume: 48 Pages: 221-222

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Medial Pivot型TKAにおける階段上り時の動作解析2018

    • Author(s)
      峯 隼人,下条竜一,野上真紀子,木村友厚
    • Journal Title

      日本人工関節学会誌

      Volume: 48 Pages: 691-692

    • Related Report
      2018 Annual Research Report
  • [Journal Article] メタローシスに伴う脛骨巨大骨欠損に対してimpacted allograftを用いて人工膝関節再置換術を施行した関節リウマチ患者の1例2018

    • Author(s)
      元村 拓,松下 功,下条竜一,野上真紀子,平岩利仁,峯 隼人,木村友厚
    • Journal Title

      整形外科

      Volume: 69 Pages: 1021-1024

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A selective c-Fos/AP-1 inhibitor prevents cartilage destruction and subsequent osteophyte formation2018

    • Author(s)
      Motomura Hiraku、Seki Shoji、Shiozawa Shunichi、Aikawa Yukihiko、Nogami Makiko、Kimura Tomoatsu
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 497 Issue: 2 Pages: 756-761

    • DOI

      10.1016/j.bbrc.2018.02.147

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain2017

    • Author(s)
      Makino Hiroto、Seki Shoji、Yahara Yasuhito、Shiozawa Shunichi、Aikawa Yukihiko、Motomura Hiraku、Nogami Makiko、Watanabe Kenta、Sainoh Takeshi、Ito Hisakatsu、Tsumaki Noriyuki、Kawaguchi Yoshiharu、Yamazaki Mitsuaki、Kimura Tomoatsu
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1

    • DOI

      10.1038/s41598-017-17289-y

    • NAID

      120006542025

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A human amnion-derived extracellular matrix-coated cell-free scaffold for cartilage repair: in vitro and in vivo studies.2016

    • Author(s)
      Nogami M, Kimura T, et al.
    • Journal Title

      Tissue Engineering

      Volume: 22 Issue: 7-8 Pages: 680-688

    • DOI

      10.1089/ten.tea.2015.0285

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 2期的両側TKAにおける手術間隔が患者立脚型評価成績に及ぼす影響2019

    • Author(s)
      野上真紀子,下条竜一,峯 隼人,元村 拓,松下 功,平岩利仁,木村友厚
    • Organizer
      第49回日本人工関節学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Medial pivot型TKAの階段昇降運動における動作解析2018

    • Author(s)
      峯 隼人,下条竜一,野上真紀子,木村友厚
    • Organizer
      第91回日本整形外科学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] PS TKAにおいて大腿骨後顆骨切り前に屈曲位コンポーネントギャップは予測できるか?2018

    • Author(s)
      下条竜一,野上真紀子,峯 隼人
    • Organizer
      第10回日本関節鏡・膝・スポーツ整形外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Differential kinematics during stair ascent and descent in medial pivot design total knee arthroplasty2018

    • Author(s)
      Mine H, Gejo R, Nogami M, Kimura T
    • Organizer
      31st Annual Congress of the International Society for Technology in Arthroplasty
    • Related Report
      2018 Annual Research Report
  • [Presentation] 家兎趾屈筋腱修復後の腱周囲の癒着防止に対するハイパードライヒト乾燥羊膜の効果2018

    • Author(s)
      頭川峰志,長田龍介,牧野紘士,野上真紀子,関 庄二,岡部泰典,吉田淑子,木村友厚
    • Organizer
      第33回日本整形外科学会基礎学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 2期的両側TKAにおいて1膝目の経験は2膝目の患者満足度に貢献するか2018

    • Author(s)
      野上真紀子、下条竜一、峯 隼人、元村 拓、松下 功、平岩利仁、木村友厚
    • Organizer
      第48回日本人工関節学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 軟骨再生治療における羊膜由来細胞と細胞外マトリックスの有用性2017

    • Author(s)
      野上 真紀子, 木村 友厚, 関 庄二, 吉田 淑子, 元村 拓, 岡部 素典, 相古 千加, 二階堂 敏雄
    • Organizer
      第16回日本再生医療学会
    • Place of Presentation
      仙台国際センター (仙台市)
    • Year and Date
      2017-03-08
    • Related Report
      2016 Research-status Report
  • [Presentation] 患者立脚型評価によるTKA術後成績調査の意義2017

    • Author(s)
      野上真紀子、下条竜一、峯 隼人、元村 拓、松下 功、平岩利仁、木村友厚
    • Organizer
      第129回中部日本整形災害外科学会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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