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Facilitatory actions of lipid emulsion on arousal and cognitive function recovery from general anesthesia.

Research Project

Project/Area Number 16K10947
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionOsaka City University

Principal Investigator

Mori Takashi  大阪市立大学, 大学院医学研究科, 准教授 (00336786)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords脂肪乳剤 / 全身麻酔薬 / 認知機能 / 覚醒 / 全身麻酔 / セボフルラン / 認知機能障害
Outline of Final Research Achievements

Since cognitive dysfunction such as delirium and restlessness during the emergence from general anesthesia may affect postoperative recovery and prognosis, however, no effective treatment exists. The purpose of the study is to determine whether lipid emulsion would be useful for the treatment. The behavioral experiments and the EEG recordings showed that lipid emulsion facilitated the arousal from general anesthesia induced by sevoflurane. To clarify the action and mechanisms of lipid emulsion on cognitive function recovery from general anesthesia are future goal.

Academic Significance and Societal Importance of the Research Achievements

本研究の特色は、局所麻酔薬中毒治療ガイドラインにもなった脂肪乳剤によるリッピドレスキューを、全身麻酔薬からの覚醒促進方法として検討することである。現時点での研究結果から、脂肪乳剤にセボフルラン全身麻酔からの覚醒を促進することが分かった。今後、認知機能の回復効果、機序についても明らかにしていく必要がある。このような効果が明らかになれば、脂肪乳剤の投与が、全身麻酔後の覚醒遅延、せん妄、不穏への対処法の1つとして応用できる可能性がある。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (20 results)

All 2020 2019 2018 2017 2016

All Journal Article (7 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Effects of sevoflurane and desflurane on the nociceptive responses of substantia gelatinosa neurons in the rat spinal cord dorsal horn: An in vivo patch-clamp analysis2020

    • Author(s)
      Yosuke Inada, Yusuke Funai, Hiroyuki Yamasaki, Takashi Mori, and Kiyonobu Nishikawa
    • Journal Title

      Molecular Pain

      Volume: 16 Pages: 1-14

    • DOI

      10.1177/1744806920903149

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 神経麻酔分野の薬剤投与エラー対策 誤接続防止コネクタの導入2020

    • Author(s)
      森隆
    • Journal Title

      Anet

      Volume: 24 Pages: 12-15

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Microcuff Pediatric Endotracheal Tube Decreases the Tube Exchange Ratio without Increasing Postoperative Complications in Japanese Children: A Single Center Retrospective Cohort Study2019

    • Author(s)
      Yosuke Inada, Yusuke Funai, Takashi Shutou, Takashi Mori, Kiyonobu Nishikawa
    • Journal Title

      Osaka City Medical Journal

      Volume: 65 Pages: 109-118

    • Related Report
      2019 Annual Research Report
  • [Journal Article] General Anesthesia Management for Adult Mucopolysaccharidosis Patients Undergoing Major Spine Surgery2019

    • Author(s)
      Tsuchiya Masahiko、Terai Hidetomi、Mizutani Koh、Funai Yusuke、Tanaka Katsuaki、Yamada Tokuhiro、Mori Takashi、Nishikawa Kiyonobu
    • Journal Title

      Medical Principles and Practice

      Volume: 28 Issue: 6 Pages: 581-585

    • DOI

      10.1159/000503051

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 局所麻酔薬中毒2019

    • Author(s)
      西川精宣, 森 隆
    • Journal Title

      日本臨床麻酔学会誌

      Volume: 39 Pages: 391-399

    • NAID

      130007686806

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Comparison between hemodynamic effects of propofol and thiopental during general anesthesia induction with remifentanil infusion: a double-blind, age-stratified, randomized study2019

    • Author(s)
      Hideki Hino, Tadashi Matsuura, Yuki Kihara, Shogo Tsujikawa, Takashi Mori, Kiyonobu Nishikawa
    • Journal Title

      Journal of Anesthesia

      Volume: 33 Issue: 4 Pages: 509-515

    • DOI

      10.1007/s00540-019-02657-x

    • NAID

      40021971782

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of esophageal perforation after intraoperative transesophageal echocardiography in a patient with a giant left atrium: unexpectedly large distortion of the esophagus revealed on retrospectively constructed three-dimentional imaging2019

    • Author(s)
      Aya Kimura, Takashi Mori, Yuki Kihara , Chie Watanabe, Katsuaki Tanaka, Tokuhiro Yamada, Atsushi Yoshida, Joji Kawabe, Yoshito Sakon, Toshihiko Shibata, Kiyonobu Nishikawa
    • Journal Title

      JA Clinical Reports

      Volume: 5 Issue: 1 Pages: 21-24

    • DOI

      10.1186/s40981-019-0243-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] セボフルランとデスフルランにおける脊髄侵害応答の違いー細胞外記録法およびin vivo パッチクランク法での検討2019

    • Author(s)
      稲田陽介、舟井優介、山崎広之、森 隆、西川精宣
    • Organizer
      日本麻酔科学会第66回学術集会,
    • Related Report
      2019 Annual Research Report
  • [Presentation] 心肥大モデルラットにおける局所麻酔薬による心抑制の増加とTRPCチャネルの影響2019

    • Author(s)
      日野秀樹、松浦正、辻川翔吾、堀耕太郎、森 隆、西川精宣
    • Organizer
      日本麻酔科学会第66回学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 抜管約4時間後に上気道閉塞を来した腰椎手術の1症例2019

    • Author(s)
      平井杏奈, 矢部充英, 森隆, 土屋正彦, 西川精宣
    • Organizer
      日本麻酔科学会第65回関西支部学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 胸椎前方後方同時固定術の翌日に大量血胸を来した症例2019

    • Author(s)
      安田信太, 舟井優介, 辻本さやか, 山田徳洪, 森隆, 西川精宣
    • Organizer
      日本麻酔科学会第65回関西支部学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 中咽頭癌摘出術後の動脈性出血に対する止血術中に重度脳梗塞をきたした一例2019

    • Author(s)
      兼松理恵子, 山崎広之, 森隆, 西川精宣
    • Organizer
      日本麻酔科学会第65回関西支部学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 遺伝性表皮水疱症の一型、Kindler症候群の麻酔経験2019

    • Author(s)
      脇彩也香, 堀耕太郎, 松浦正, 森隆, 西川精宣
    • Organizer
      日本麻酔科学会第65回関西支部学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脊髄くも膜下麻酔による帝王切開術中に意識消失をきたした1例2019

    • Author(s)
      黒木円花, 首藤喬, 末廣浩一, 森隆, 西川精宣
    • Organizer
      日本臨床麻酔学会第39回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The Effects of Desflurane and Sevoflurane on Nociceptive Responses in Dorsal Horn: In Vivo Patch-clamp Analyses2018

    • Author(s)
      Yosuke Inada, Yusuke Funai, Hiroyuki Yamasaki, Takashi Mori, Kiyonobu Nishikawa
    • Organizer
      2018 Annual Meeting, American Society of Anesthesiologists
    • Related Report
      2018 Research-status Report
  • [Presentation] 局所麻酔薬の薬理-From Origin to the Ocean2018

    • Author(s)
      森 隆
    • Organizer
      日本区域麻酔学会第5回学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 先制鎮痛による神経障害性疼痛予防効果の検討2017

    • Author(s)
      山崎広之, 森隆, 舟井優介, 西川精宣
    • Organizer
      日本区域麻酔学会第4回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Lipid emulsion facilitates reversal from sevoflurane anaesthesia in a rodent model.2017

    • Author(s)
      Hino H., Matsuura T., Hori K., Tsujikawa S., Mori T., Nishikawa K.
    • Organizer
      Euroanaesthesia 2017 (The European Anaesthesia Congress)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Superiority of Lipid Infusion Over Serum Alkalinization in Reversal of Amitriptyline Cardiotoxicity in Guinea Pigs.2016

    • Author(s)
      Shogo Tsujikawa, Tadashi Matsuura, Kotaro Hori, Takashi Mori, Miyuki Kuno, Kiyonobu Nishikawa
    • Organizer
      2016 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      シカゴ(米国)
    • Year and Date
      2016-10-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Book] 全身麻酔後の上肢・下肢の神経障害: 横山正尚編集, 麻酔科医のための周術期危機管理と合併症への対応2016

    • Author(s)
      森隆, 西川精宣
    • Total Pages
      286
    • Publisher
      中山書店, 東京
    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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