Development of puncture navigation synchronized with 2D real time ultrasound to 3D anatomical information

• Project/Area Number: 16K11025
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: YAMADA YASUHIRO 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20388185)
• Co-Investigator(Kenkyū-buntansha): 鴨井 和実 京都府立医科大学, 医学(系)研究科(研究院), 講師 (40295663) ; 浮村 理 京都府立医科大学, 医学(系)研究科(研究院), 教授 (70275220) ; 沖原 宏治 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (80285270) ; 本郷 文弥 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (80291798) ; 牛嶋 壮 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10398373) ; 金沢 元洪 京都府立医科大学, 医学(系)研究科(研究院), 助教 (00468266) ; 藤原 敦子 京都府立医科大学, 医学(系)研究科(研究院), 講師 (20457980)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 手術ナビゲーション / 前立腺癌 / 腎癌 / 局所療法 / 癌局所療法 / 穿刺ナビゲーション / 穿刺ナビゲーションシステム / 局所治療 / Image fusion / 経皮的治療

Outline of Final Research Achievements

Development of a new surgical navigation system incorporating virtual reality and mixed reality. Performs a prostate biopsy, which enables three-dimensional information constructed from CT or MRI taken before surgery to be superimposed on a CG image as a hologram on the patient's body and to accurately grasp the anatomy. It was confirmed that highly accurate prostate biopsy could be performed. We plan to use the system for local treatment of prostate cancer in the future, and we will prove that it helps improve the accuracy of actual cancer treatment.

Academic Significance and Societal Importance of the Research Achievements

小径腎腫瘍や前立腺癌に対する低侵襲治療として凍結療法やラジオ波焼灼術などの経皮的治療が行われている。穿刺時にはCT、MRI、超音波画像などによる２次元画像システムが用いられているが、現在の２次元画像システムでは、穿刺対象の臓器の3次元的な構造の中で、どの断面で穿刺すべきかの把握が困難であり、正確な局所療法を行うには不十分である。３Dナビゲーションの開発で、今後の治療精度の改善が期待できる。

Research Products

• [Journal Article] Magnetic resonance imaging/transrectal ultrasound fusion‐targeted prostate biopsy using three‐dimensional ultrasound‐based organ‐tracking technology: Initial experience in Japan (2019)
  • Author(s): Yamada Yasuhiro、Fujihara Atsuko、Shiraishi Takumi、Ueda Takashi、Yamada Takeshi、Ueno Akihisa、Inoue Yuta、Kaneko Masatomo、Kamoi Kazumi、Hongo Fumiya、Okihara Koji、Ukimura Osamu
  • Journal Title: International Journal of Urology Volume: 26 Issue: 5 Pages: 544-549
  • DOI: 10.1111/iju.13924
  • Peer Reviewed / Open Access
• [Journal Article] Biochemical and magnetic resonance image response in targeted focal cryotherapy to ablate targeted biopsy‐proven index lesion of prostate cancer (2018)
  • Author(s): Inoue Yuta、Ushijima So、Shiraishi Takumi、Fujihara Atsuko、Hongo Fumiya、Ukimura Osamu
  • Journal Title: International Journal of Urology Volume: 26 Issue: 2 Pages: 317-319
  • DOI: 10.1111/iju.13857
  • Peer Reviewed
• [Presentation] Virtual reality and mixed reality in urologic surgery (2019)
  • Author(s): 山田恭弘
  • Organizer: International Symposium on Focal Therapy and Imaging in Prostate and Kidney Cancer
  • Int'l Joint Research
• [Presentation] Focal salvage low dose brachytherapy based on 3D cancer mapping (2019)
  • Author(s): 山田恭弘
  • Organizer: International Symposium on Focal Therapy and Imaging in Prostate and Kidney Cancer
  • Int'l Joint Research
• [Presentation] Microwave irradiation of dog prostate (2019)
  • Author(s): 山田恭弘
  • Organizer: International Symposium on Focal Therapy and Imaging in Prostate and Kidney Cancer
  • Int'l Joint Research