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The development of new agents for the interstital cystitis / bladder pain syndrome base on gene profile

Research Project

Project/Area Number 16K11045
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionShinshu University

Principal Investigator

Ogawa Teruyuki  信州大学, 学術研究院医学系, 准教授 (90467142)

Co-Investigator(Kenkyū-buntansha) 今村 哲也  信州大学, 学術研究院医学系, 助教 (00467143)
石塚 修  信州大学, 学術研究院医学系, 教授 (20184541)
永井 崇  信州大学, 学術研究院医学系(医学部附属病院), 助教 (50514353)
平形 志朗  信州大学, 学術研究院医学系, 助教 (90749475)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords間質性膀胱炎 / ケモカイン / 生理学 / 薬剤反応性
Outline of Final Research Achievements

Interstitial cystitis/bladder pain syndrome (IC/BPS) is one of the refractory diseases, which induces urinary frequency and bladder pain. The pathophysiology is unknown, therefore it is difficult to treat. We previously reported that genes related to inflammation and immune mechanism are highly associated with the pathogenesis of IC/BPS, therefore we planned to establish the rat cystitis models which express the same gene profile in the bladder. It is considered that the models are important to evaluate the efficacy of agents for treatment of IC/BPS. We found that rats which were locally irradiated to the bladder express the almost same gene profile as that of the human IC/BPS. In conclusion, the models are useful for the future research for the treatment of IC/BPS.

Academic Significance and Societal Importance of the Research Achievements

ヒト間質性膀胱炎の遺伝子発現と類似した動物モデルを作成することができた。
今後はそのモデルにおいて薬物治療を行うことで、病態を改善することが可能か、排尿機能ならびに組織学的に検討することで、今後の治療の基礎になると思われる

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2019 2018 2017 2016

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (6 results)

  • [Journal Article] Pharmacological management of interstitial cystitis /bladder pain syndrome and the role cyclosporine and other immunomodulating drugs play.2018

    • Author(s)
      Ogawa T, Ishizuka O, Ueda T, Tyagi P, Chancellor MB, Yoshimura N.
    • Journal Title

      Expert Rev Clin Pharmacol.

      Volume: 11(5) Issue: 5 Pages: 495-505

    • DOI

      10.1080/17512433.2018.1457435

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combined treatment with a β3 -adrenergic receptor agonist and a muscarinic receptor antagonist inhibits detrusor overactivity induced by cold stress in spontaneously hypertensive rats2017

    • Author(s)
      Imamura T, Ogawa T, Minagawa T, Nagai T, Suzuki T, Saito T, Yokoyama H, Nakazawa M, Ishizuka O
    • Journal Title

      Neurourol Urodyn

      Volume: 36 Issue: 4 Pages: 1026-1033

    • DOI

      10.1002/nau.23061

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prevalence and treatment of LUTS in patients with Parkinson disease or multiple system atrophy2016

    • Author(s)
      Ogawa T, Sakakibara R, Kuno S, Ishizuka O, Kitta T, Yoshimura N.
    • Journal Title

      Nature Revue Urology

      Volume: Epub ahead of print Issue: 2 Pages: 1-2

    • DOI

      10.1038/nrurol.2016.254

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 特集 排尿障害とその対処への実践 専門医による下部尿路機能評価.2016

    • Author(s)
      小川輝之
    • Journal Title

      WOC Nursing

      Volume: 4(1) Pages: 26-33

    • Related Report
      2016 Research-status Report
  • [Journal Article] 前立腺肥大症の薬物療法ー使い分けのポイント(併用・追加・代替療法)植物エキス・生薬・漢方薬.2016

    • Author(s)
      小川輝之、今村哲也、石塚修
    • Journal Title

      臨床泌尿器科

      Volume: 70(6) Pages: 429-432

    • Related Report
      2016 Research-status Report
  • [Presentation] シクロフォスファミドと放射線照射によって誘発してラット膀胱炎の特異的遺伝子発現との類似性の検討2019

    • Author(s)
      今村哲也、小川輝之、鈴木都史郎、上野学、鈴木中、原寛敦、井上貴裕、永井崇、皆川倫範、石塚修
    • Organizer
      第107回日本泌尿器科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 尿流動態検査の結果からみた前立腺肥大症患者の至適手術時期の検討2016

    • Author(s)
      斎藤徹一、石川雅邦、永井 崇、皆川倫範、小川輝之、市野みどり、石塚 修
    • Organizer
      第23回日本排尿機能学会
    • Place of Presentation
      東京・東京国際フォーラム
    • Year and Date
      2016-12-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 前立腺癌に対する密封小線源治療後下部尿路症状の病態についての検討2016

    • Author(s)
      大門裕典、皆川倫範、山岸貴裕、小川輝之、石塚 修
    • Organizer
      第23回日本排尿機能学会
    • Place of Presentation
      東京・東京国際フォーラム
    • Year and Date
      2016-12-07
    • Related Report
      2016 Research-status Report
  • [Presentation] PDE阻害薬連続投与によるラット蓄尿機能変化と冷えストレスによる排尿筋過活動の抑制効果の検討2016

    • Author(s)
      永井 崇、今村哲也、小川輝之、皆川倫範、鈴木都史郎、斎藤徹一、石塚 修
    • Organizer
      第23回日本排尿機能学会
    • Place of Presentation
      東京・東京国際フォーラム
    • Year and Date
      2016-12-07
    • Related Report
      2016 Research-status Report
  • [Presentation] 女性における過活動膀胱治療薬の服薬継続率について2016

    • Author(s)
      小川輝之、皆川倫範、加賀美慧帆、松高 淳、小川典之、大門裕典、斎藤徹一、鈴木都史郎、道面尚久、石川雅邦、永井 崇、平形志朗、今村哲也、石塚 修
    • Organizer
      第81回日本泌尿器学会東部総会
    • Place of Presentation
      青森・リンクステーションホール青森
    • Year and Date
      2016-10-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 女性OAB薬物治療の長期アウトカム 治療継続性について2016

    • Author(s)
      小川輝之、皆川倫範、石塚修
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台・仙台国際センター
    • Year and Date
      2016-04-24
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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