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Effects of Estrogen Receptor Stimulation to Non-Bacterial Prostatic Inflammation

Research Project

Project/Area Number 16K11051
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionOita University

Principal Investigator

Mori Kenichi  大分大学, 医学部, 客員研究員 (00579013)

Co-Investigator(Kenkyū-buntansha) 三股 浩光  大分大学, 医学部, 教授 (60219714)
Research Collaborator Yoshimura Naoki  ピッツバーグ大学, 泌尿器科, 教授
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords前立腺 / エストロゲン受容体 / 炎症 / 選択的ERβ刺激薬 / 非細菌性慢性前立腺炎 / エストロゲン受容体α / エストロゲン受容体β / 選択的ERβアゴニスト / 慢性前立腺炎 / 過活動膀胱 / 前立腺炎 / 生体分子
Outline of Final Research Achievements

There is increasing evidence showing that chronic non-bacterial prostatic inflammation is involved in the pathogenesis of benign prostatic hyperplasia (BPH) and male lower urinary tract symptoms (LUTS). It has also been reported that estrogen receptor β (ERβ) could have an immunoprotective role in prostatic tissue. Therefore, we investigated the effect of ERβ-activation on not only prostatic inflammation, but also bladder overactive conditions in a rat model with nonbacterial prostatic inflammation. ERβ activation by 3α-Adiol administration, which normalized the ERβ/ERα expression ratio in the prostate, can improve not only prostatic inflammation, but also bladder overactivity. Therefore, ERβ agonists might be useful for treating irritative bladder symptoms in patients with symptomatic BPH associated with prostatic inflammation.

Academic Significance and Societal Importance of the Research Achievements

非細菌性慢性前立腺炎の患者は非常に多く、会陰部不快感や頻尿などの下部尿路症状が持続しQOLを著しく損なうことが報告されている。治療はα1アドレナリン受容体遮断薬を主体として行われるが、十分な効果が得られない症例も少なくなく治療が長期化することも多い。非細菌性慢性前立腺炎の病態は未だ不明なこと多く、有効な炎症性マーカーや治療法の選択肢が非常に少ないのが 現状であったが、非細菌性慢性前立腺炎に対する選択的ERβアゴニストの有効性と IL-18 の炎症性マーカーとしての有効性を見出したことは、新規治療薬開発の基盤研究となり非常に学術的意義は大きいものと考える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (13 results)

All 2019 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (12 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Effects of Estrogen Receptor β Stimulation in a Rat Model of Non-Bacterial Prostatic Inflammation.2017

    • Author(s)
      Shinsuke Mizoguchi, Kenichi Mori, Zhou Wang, Teresa Liu, Yasuhito Funahashi, Fuminori Sato, Donald B. DeFranco, Naoki Yoshimura
    • Journal Title

      Prostate

      Volume: 77 Issue: 7 Pages: 803-811

    • DOI

      10.1002/pros.23320

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 非細菌性前立腺炎モデルラットにおけるセルニチンポーレンエキス(T60, GBX)投与効果の検討2019

    • Author(s)
      山中 直行、森 健一、三股 浩光
    • Organizer
      第28回泌尿器科分子・細胞研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Prostatic enlargement with chronic inflammation due to alteration of estrogen receptors and fatty acid composition in high fat induced obesity rat model2018

    • Author(s)
      Yamanaka Naoyuki, Mori Kenichi, Mizoguchi Shinsuke, Mimata Hiromitsu
    • Organizer
      アメリカ泌尿器科学会2018(AUA2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 食餌誘発性肥満モデルラットにおける前立腺肥大症と前立腺組織の炎症・性腺ホルモン受容体・脂 肪酸の解析2018

    • Author(s)
      山中直行、森 健一、三股浩光
    • Organizer
      第106回日本泌尿器科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] セルニチンポレーンエキス (T60, GBX) は非細菌性前立腺炎モデルラットの前立腺炎症を 改善する2018

    • Author(s)
      山中 直行、森 健一、三股 浩光
    • Organizer
      第25回日本排尿機能学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cernitin pollen extract can improve overactive bladder condition in a rat model of non-bacterial prostatitis in short term2018

    • Author(s)
      Naoyuki Y, Kenichi M, Shinsuke M, Hiromitsu M
    • Organizer
      国際尿禁制学会2018(ICS2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] INVOLVEMENT OF TOLL-LIKE RECEPTOR 4 IN NONBACTERIAL BLADDER INFLAMMATION AND FREQUENT URINATION VIA INFLAMMASOME PATHWAYS IN SPONTANEOUSLY HYPERTENSIVE RATS2017

    • Author(s)
      Shinsuke Mizoguchi, Ken-ichi Mori, Naoyuki Yamanaka, Fuminori Sato, Naoki Yoshimura, Hiromitsu Mimata
    • Organizer
      The 2017 Annual Meeting of the American Urological Association
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Inflammasome is an important mediator of chronic bladder inflammation in spontaneously hypertensive rats2017

    • Author(s)
      Shinsuke Mizoguchi, Ken-ichi Mori, Fuminori Sato, Naoki Yoshimura, Hiromitsu Mimata
    • Organizer
      EAU 2107
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 食餌誘発性肥満モデルラットの前立腺組織におけるエストロゲンレセプター発現解析2017

    • Author(s)
      山中直行、森 健一、溝口晋輔、三股浩光
    • Organizer
      第24回日本排尿機能学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 食餌誘発性肥満モデルラットにおける前立腺炎の解析2017

    • Author(s)
      山中直行、森 健一、溝口晋輔、三股浩光
    • Organizer
      第24回日本排尿機能学会
    • Related Report
      2017 Research-status Report
  • [Presentation] ラット非細菌性前立腺炎モデルにおけるエストロゲン受容体 β を介した デュタステリドによる炎症改善効果2016

    • Author(s)
      溝口 晋輔、森 健一、吉村 直樹、三股 浩光
    • Organizer
      第23回日本排尿機能学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
  • [Presentation] SUPPRESSION OF BLADDER OVERACTIVITY BY ESTROGEN RECEPTOR Β ACTIVATION IN RATS WITH CHRONIC NON-BACTERIAL PROSTATITIS2016

    • Author(s)
      MIZOGUCHI S, MORI K, YOSHIMURA N, MIMATA H
    • Organizer
      ICS 2016 (International Continence society)
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] INVOLVEMENT OF INCREASED EXPRESSION OF ESTROGEN RECEPTOR Β IN THE ANTI-INFLAMMATORY EFFECTS OF DUTASTERIDE IN A RAT MODEL OF NON-BACTERIAL PROSTATIC INFLAMMATION2016

    • Author(s)
      MIZOGUCHI S, MORI K, YOSHIMURA N, MIMATA H
    • Organizer
      ICS 2016 (International Continence society)
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2016-09-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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