The establishment of a novel endometriosis model and the understanding of the developmental mechanism of endometriosis.
| Project/Area Number |
16K11108
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
MASUDA Hirotaka 慶應義塾大学, 医学部(信濃町), 講師 (80317198)
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| Co-Investigator(Kenkyū-buntansha) |
丸山 哲夫 慶應義塾大学, 医学部(信濃町), 准教授 (10209702)
内田 浩 慶應義塾大学, 医学部(信濃町), 講師 (90286534)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 子宮内膜症 / 磁気ビーズ / モデルマウス / イメージングシステム / Bioluminescence imaging / 上皮間葉転換（EMT） / 子宮内膜幹細胞 / 上皮間葉転換 / 生殖医学 |
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| Outline of Final Research Achievements |
We developed a non-invasive and real-time assessment system using in vivo bioluminescent imaging to quantitate human endometrium-derived cells transplanted in the murine peritoneal cavity, which demonstrate its possibility as a peritoneal endometriosis model.
Human eutopic endometrial cells occurred EMT via EMT induction, while endometriotic epithelia showed a variety of EMT status according to a type of endometriosis. Therefore, EMT was thought to be involved in the establishment and the development of endometriosis. ZEB1 was likely to be expressed in endometriotic epithelia of invasive endometriosis, but not in eutopic endometrial epithelia. An EMT inhibitor could suppress adhesive capacity and motility of endometrial epithelial cells, indicating that the inhibitor could prevent the establishment and development of endometriosis. An EMT inhibitor can be a novel drug for endometriosis.
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| Academic Significance and Societal Importance of the Research Achievements |
子宮内膜症は不妊症に限らず、月経のある女性の6-10%に発症し、全世界で1.8 億人が月経困難や下腹部痛などによりQOL の低下を余儀なくされ、その経済的損失は患者・週あたり456 米ドル（Nnoaham et.al. FetilSteril. 2011）と算出されている。日本においても、年間約3800 億円の経済的損失（平成12 年度厚生科学研究報告書）があると計算されている。さらには、上皮性卵巣癌や腹膜癌の前癌病変とも考えられ、社会的にもインパクトの大きい疾患である。よって、子宮内膜症の解明や治療は、大きな社会的貢献につながると考えられる。
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] ZEB1 expression is a potential indicator of invasive endometriosis2017
Author(s)
Furuya M, Masuda H, Hara K, Uchida H, Sato K, Sato S, Asada H, Maruyama T, Yoshimura Y, Katabuchi H, Tanaka M, Saya H
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Journal Title
Acta Obstet Gynecol Scand
Volume: 96
Issue: 9
Pages: 1128-1135
DOI
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Peer Reviewed
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[Presentation] Anovel approach to treat emdometriosis via targeting epithelial-mesenchymal transition2018
Author(s)
Hirotaka Masuda, Masataka Furuya, Tetsuo Maruyama, Fumie Miki, Satomi Katakura, Yushi Yoshimasa, Sayaka Uchida, Hiroshi Uchida, Tomoka Takao, Hidetaka Katabuchi, Mamoru Tanaka, Daisuke Aoki
Organizer
第70回日本産科婦人科学会
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[Presentation] Differential status of epithelial-mesenchymal transition in endometriosis and adenomyosis: ZEBI as a potential indicator of endometriotic invasiveness2017
Author(s)
Hirotaka Masuda, Masataka Furuya, Hironori Asada, Tetsuo Maruyama, Hiroshi Uchida, Sayaka Uchida, Yasunori Yoshimura, Hidetaka Katabuchi, Hideyuki Saya, Mamoru Tanaka, Daisuke Aoki
Organizer
第69回日本産科婦人科学会International Session
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