activation regulatory mechanism of cancer fibroblast by obesity

Research Project

Project/Area Number	16K11163
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Obstetrics and gynecology
Research Institution	Osaka Medical College
Principal Investigator	Takai Masaaki 大阪医科大学, 医学部, 非常勤医師 (90770933)
Co-Investigator(Kenkyū-buntansha)	林正美大阪医科大学, 医学部, 准教授 (00551748) 大道正英大阪医科大学, 医学部, 教授 (10283764) 恒遠啓示大阪医科大学, 医学部, 講師 (70388255) 佐々木浩大阪医科大学, 医学部, 講師 (80432491) 兪史夏大阪医科大学, 医学部, 非常勤医師 (80625674) 寺井義人大阪医科大学, 医学部, 非常勤講師 (90278531) 藤原聡枝大阪医科大学, 医学部, 講師 (90707960)
Project Period (FY)	2016-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords	癌関連繊維芽細胞 / 子宮体がん / 肥満 / 癌関連線維芽細胞 / 子宮体癌
Outline of Final Research Achievements	The relation between obesity and endometrium cancer is unknown. At First, we measured the amount of visceral fat and subcutaneous fat in endometrial cancer patients. The amount of visceral fat was related with prognosis and recurrence rate. Next, FABP4 which is cytokine from visceral fat was treated in endometrial cancer cell lines, cell lines were proliferated. Furthermore, we made the tissue microarray of 354 endometrial cancer patients, and when immunostaining of EMT related protein (Snail, Slug, TWIST, E-cadherin) was performed, the EMT related proteins were increased. The amount of visceral fat of obesity patients would be related with prognosis or recurrence rate in endometrial cancer patients.
Academic Significance and Societal Importance of the Research Achievements	我々が肥満および内臓脂肪と子宮体がんの転移・再発に関するメカニズムの一部を解明したことにより、今後子宮体がんの発症予防や治療開発において新たな戦略を構築できる可能性があり、子宮体がん患者の予後改善につながると考える。