| Project/Area Number |
16K11175
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | University of Fukui |
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Principal Investigator |
Okamoto Masayuki 福井大学, 学術研究院医学系部門(附属病院部), 講師 (90464057)
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| Co-Investigator(Kenkyū-buntansha) |
山田 武千代 秋田大学, 医学系研究科, 教授 (70283182)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 顔面神経麻痺 / 軸索伸長 / DISC1 / 顔面神経 / 遺伝子治療 / 神経科学 |
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| Outline of Final Research Achievements |
It was confirmed that the axon length of DISC1 overexpressing neuron was significantly longer as compered control neurons. In microtubule dynamics visualized using Endobinding protein-3(EB3), no significant change was observed by DISC1 overexpression. It was thought that the increase in the expression level of DISC1 resulted in the enhancement of the function of the microtubule stabilizing molecule at the tip of the microtubule, and as a result, it was suggested that axonal elongation was promoted.
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| Academic Significance and Societal Importance of the Research Achievements |
顔面神経麻痺の治療において、麻痺が高度な場合は早期に適切な治療を行っても治癒に至らない症例や後遺症が残る症例が存在する。このような高度麻痺例の 予後改善のためには神経障害部位においてワーラー変性を来した神経の新たな軸索伸展および再髄鞘化を促すことが重要である。軸索伸展 において重要な働きをするタンパクであるDISC1を遺伝子導入によって顔面神経軸索再生治療を行えるようになれば、顔面神経麻痺の治癒率向上に寄与するものとなる。
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