Analysis of congenital deafness caused by a novel molecule to develop prevention and treatment

• Project/Area Number: 16K11177
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nagoya University
• Principal Investigator: Sone Michihiko 名古屋大学, 医学系研究科, 教授 (30273238)
• Co-Investigator(Kenkyū-buntansha): 加藤 昌志 名古屋大学, 医学系研究科, 教授 (10281073) ; 大神 信孝 名古屋大学, 医学系研究科, 講師 (80424919)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ラセン神経節 / 内耳 / 難聴 / 有毛細胞 / 騒音 / 聴覚医学 / モデル動物

Outline of Final Research Achievements

Congenital deafness appears at a rate of 1/1000 at birth, which is the most frequent disease among congenital disorders. Cochlear implantation is an efficient therapy, however, the existence of the spiral ganglion cell is fundamentally necessary. Recently, the molecule G attracts the worldwide attention because of its neurotrophic and migration properties.
In order to obtain basic data concerning the development of prevision, prevention and treatment for congenital deafness, we analyzed the mechanism in which the molecule G could induce the congenital deafness. The study has demonstrated that the molecule G is essential factor for the development of the auditory function in mice.

Academic Significance and Societal Importance of the Research Achievements

現在までに、動物でもヒトでも分子Gが難聴に関与することを示した論文はない。本研究により、世界で初めて本分子が聴力に関与していることを個体レベルで証明出来た。現時点では聴神経障害型の先天性難聴に対して人工内耳植込術の有効性を期待する事は難しいが、本研究により分子Gは聴覚系の神経の発達に関与している可能性が示された事から、今後、本分子の活性化により聴神経の障害を防ぐ事が出来れば、人工内耳植込術の有効性の向上が期待される。

Research Products

• [Journal Article] Improvement of balance in young adults by a sound component at 100?Hz in music (2018)
  • Author(s): Xu Huadong、Ohgami Nobutaka、He Tingchao、Hashimoto Kazunori、Tazaki Akira、Ohgami Kyoko、Takeda Kozue、Kato Masashi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 16894-16894
  • DOI: 10.1038/s41598-018-35244-3
  • Peer Reviewed / Open Access
• [Journal Article] Arsenic level in toenails is associated with hearing loss in humans. (2018)
  • Author(s): Li X, Ohgami N, Yajima I, Xu H, Iida M, Oshino R, Ninomiya H, Shen D, Ahsan N, Akhand AA, Kato M.
  • Journal Title: PLoS One Volume: 13
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] anganese in toenails is associated with hearing loss at high frequencies in humans. (2018)
  • Author(s): hgami N, Li X, Yajima I, Oshino R, Ohgami K, Kato Y, Ahsan N, Akhand AA, Kato M.
  • Journal Title: Biomarkers Volume: 23 Pages: 533-539
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Increased expression level of Hsp70 in the inner ears of mice by exposure to low frequency noise. (2018)
  • Author(s): Ninomiya H, Ohgami N, Oshino R, Kato M, Ohgami K, Li X, Shen D, Iida M, Yajima I, Angelidis CE, Adachi H, Katsuno M, Sobue G, Kato M.
  • Journal Title: Hear Res Volume: - Pages: 49-54
  • DOI: 10.1016/j.heares.2018.02.006
  • NAID: 120006517664
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 聴域の騒音ストレスによるラセン神経節への影響 (2019)
  • Author(s): 大神信孝、He Tingchao、Xu Huadong、押野玲奈、李香、加藤昌志
  • Organizer: 第89回日本衛生学会学術総会
• [Patent(Industrial Property Rights)] 音発生装置 (2018)
  • Inventor(s): 加藤昌志、大神信孝、曽根三千彦、杉本賢文
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2018