Development of a new treatment for sequelae of facial nerve palsy

• Project/Area Number: 16K11185
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Ehime University
• Principal Investigator: Hato Naohito 愛媛大学, 医学系研究科, 教授 (60284410)
• Co-Investigator(Kenkyū-buntansha): 山田 啓之 愛媛大学, 医学部附属病院, 講師 (00403808) ; 岡田 昌浩 愛媛大学, 医学部附属病院, 講師 (20512130) ; 鵜久森 徹 愛媛大学, 医学系研究科, 准教授 (80512128)
• Research Collaborator: Joko Tomonori ; Kimura Takuya
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 顔面神経 / 再生医療 / 栄養因子 / DDS / 顔面神経麻痺 / 神経再生 / 冷却刺激 / 単純ヘルペスウイルス / 神経科学

Outline of Final Research Achievements

Peripheral facial palsy is a poor prognosis when neuropathy is severe, and sequelae is inevitable. It is necessary to promote regeneration of the nerve for cases of severe paralysis but it has not been universalized. Therefore, we sought to develop a treatment that could be easily treated with otolaryngology outpatients, with few complications, and with a high therapeutic effect, and conceived of an intratympanic administration of a controlled release nutritional factor. We succeeded in creating a reproducible high facial nerve paralysis model by local cooling, and observed the facial nerve paralysis regeneration by slow release administration of bFGF. Histologically and electrophysiologically, the nerve regeneration was evaluated, and compared with the control, bFGF sustained-release administration rapidly improved the facial nerve palsy and caused less aftereffects.

Academic Significance and Societal Importance of the Research Achievements

顔面神経麻痺は高度となれば後遺症が必発であるが、新しく低侵襲な顔面神経の再生治療法を動物実験で確立した。経鼓膜的に鼓室内に徐放化栄養因子を投与すれば、高度に障害を受けた顔面神経麻痺モルモットが早く良好に回復した。この方法は臨床応用が可能で、今後は臨床試験の準備を行う予定である。

Research Products

• [Journal Article] 顔面神経麻痺の診断と治療 (2017)
  • Author(s): 羽藤 直人
  • Journal Title: Nippon Jibiinkoka Gakkai Kaiho Volume: 120 Issue: 1 Pages: 58-61
  • DOI: 10.3950/jibiinkoka.120.58
  • NAID: 130005330302
  • ISSN: 0030-6622, 1883-0854
• [Journal Article] 【顔面神経麻痺のリハビリテーションによる機能回復】 難治性の顔面神経麻痺の治療 私の工夫(2) (2017)
  • Author(s): 羽藤 直人
  • Journal Title: ENTONI Volume: 203号 Pages: 71-75
• [Journal Article] Facial paralysis induced by ear inoculation of herpes simplex virus in rat (2017)
  • Author(s): Fujiwara T, Matsuda S, Tanaka J, Hato N
  • Journal Title: Auris Nasus Larynx. Volume: 44(1): Issue: 1 Pages: 58-64
  • DOI: 10.1016/j.anl.2016.04.002
  • Peer Reviewed
• [Presentation] 冷却障害による顔面神経麻痺モデルの検討 (2017)
  • Author(s): 上甲 智規, 山田 啓之, 羽藤 直人
  • Organizer: Otology Japan