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Elucidation of pathology of hearing loss in complex sound ABR (cABR)

Research Project

Project/Area Number 16K11196
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Otorhinolaryngology
Research InstitutionKeio University

Principal Investigator

OKAMOTO Yasuhide  慶應義塾大学, 医学部(信濃町), 客員講師 (10317224)

Co-Investigator(Kenkyū-buntansha) 入野 俊夫  和歌山大学, システム工学部, 教授 (20346331)
神崎 晶  慶應義塾大学, 医学部(信濃町), 講師 (50286556)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords感音難聴 / 後迷路性難聴 / 時間分解能 / ABR / 複合音ABR / 蝸電図 / Auditory Neuropathy / 聴性脳幹反応 / 周波数選択性 / 語音明瞭度 / 劣化音声
Outline of Final Research Achievements

Deaf people can hear the sound. However, words are hard to hear. This is because it becomes difficult to hear the temporal change of the voice.
This time, we investigated whether the temporal resolution could be measured by ABR.
As a result, it became possible to evaluate the temporal resolution by the method of measuring complex sound ABR (cABR). This measurement method was able to establish an objective test method for clinical temporal resolution.

Academic Significance and Societal Importance of the Research Achievements

難聴者において音の聞き取りの低下に加え言葉の聞き取りにくさを訴えることが多い。これは音声の時間的変化を聞き分ける能力、時間分解能の低下が原因と考えられる。これまで時間分解能の低下は自覚的検査の手法にて測定されてきたが、他覚的検査法は存在しなかった。他覚的方法は具体的には音声中の時間的変化はエンベロープ(Envelope)と時間微細構造(TFS: Temporal Fine Structure)によって捕らえられこの両者をABRにて把握することで例えばAuditory Neuropathy(AN)のような内有毛細胞からの発火のタイミングの障害などの病態を把握することが可能となった。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (26 results)

All 2019 2018 2017 2016

All Journal Article (13 results) (of which Open Access: 5 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 3 results) Presentation (13 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] 【耳鼻咽喉科と認知症】認知症予防の観点から考える聴覚トレーニング2019

    • Author(s)
      岡本康秀
    • Journal Title

      ENTONI

      Volume: 233 Pages: 14-21

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] Rising-frequency chirp stimulus to effectively enhance wave-I amplitude of auditory brainstem response2019

    • Author(s)
      Morimoto Takashi、Fujisaka Yoh-ichi、Okamoto Yasuhide、Irino Toshio
    • Journal Title

      Hearing Research

      Volume: 377 Pages: 104-108

    • DOI

      10.1016/j.heares.2019.03.016

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] ABRの振幅変動およびcochlear synaptopathy検出についての検討2018

    • Author(s)
      泰地秀信、岡本康秀、神崎仁
    • Journal Title

      Audiology Japan

      Volume: 61 Pages: 145-153

    • NAID

      130007404224

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【進化する補聴器診療】 補聴器による聴覚トレーニング2017

    • Author(s)
      岡本康秀
    • Journal Title

      JOHNS

      Volume: 33 Pages: 477-480

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Cochlear synaptopathy における ABR2017

    • Author(s)
      泰地 秀信, 岡本 康秀, 神崎 仁
    • Journal Title

      AUDIOLOGY JAPAN

      Volume: 60 Issue: 5 Pages: 270-270

    • DOI

      10.4295/audiology.60.270

    • NAID

      130006407465

    • ISSN
      0303-8106, 1883-7301
    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Pendred 症候群/DFNB4 (PDS) の変動性難聴の自然経過に関する検討2017

    • Author(s)
      藤岡 正人, 岡本 康秀, 加我 君孝, 小川 郁, 松永 達雄
    • Journal Title

      AUDIOLOGY JAPAN

      Volume: 60 Issue: 5 Pages: 434-434

    • DOI

      10.4295/audiology.60.434

    • NAID

      130006407692

    • ISSN
      0303-8106, 1883-7301
    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] Pendred症候群における聴力変動の年齢差および季節性の検討2017

    • Author(s)
      細谷 誠、岡本 康秀, 加我 君孝, 小川 郁, 松永 達雄
    • Journal Title

      Otology Japan

      Volume: 27 Pages: 574-574

    • Related Report
      2017 Research-status Report
    • Open Access
  • [Journal Article] 蝸牛vs前庭 類似点と相違点 Pendred症候群の蝸牛症状に関する検討2017

    • Author(s)
      藤岡 正人, 岡本 康秀, 加我 君孝, 小川 郁, 松永 達雄
    • Journal Title

      Equilibrium Research

      Volume: 76 Pages: 400-400

    • Related Report
      2017 Research-status Report
  • [Journal Article] 補聴器による聴覚トレーニング2017

    • Author(s)
      岡本康秀
    • Journal Title

      JOHNS

      Volume: 33 Pages: 477-480

    • Related Report
      2016 Research-status Report
  • [Journal Article] Auditory Neuropathyと健聴者における複合音ABRの相違2016

    • Author(s)
      岡本康秀
    • Journal Title

      日本耳鼻咽喉科学会会報

      Volume: 119 Pages: 582-582

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] Auditory Neuropathyに対するAdaptive Dynamic Range Optimization(ADRO)方式の補聴器適合と特例補装具申請について2016

    • Author(s)
      久保田江里、岡本康秀
    • Journal Title

      言語聴覚研究

      Volume: 13 Pages: 141-141

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] 高齢者の両耳融合現象に関する研究 両耳交互聴と関連する要因の検討2016

    • Author(s)
      塚原恵、岡本康秀
    • Journal Title

      Audiology Japan

      Volume: 9 Pages: 555-556

    • NAID

      130005606397

    • Related Report
      2016 Research-status Report
  • [Journal Article] 難聴高齢者における音韻修復機能について2016

    • Author(s)
      久保田江里、岡本康秀
    • Journal Title

      Audiology Japan

      Volume: 12 Pages: 623-631

    • NAID

      130005606451

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Presentation] 「言葉聞き取り困難」で受診した純音聴力正常者の心理聴覚的傾向2019

    • Author(s)
      岡本康秀
    • Organizer
      Audiology Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] DPOAE検査による低音域聴力評価2019

    • Author(s)
      泰地 秀信
    • Organizer
      Audiology Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高齢者の聴覚と暮らし方と健康に関する学術調査(第2報)老人性難聴のリスクファクターの探索2019

    • Author(s)
      忰田 かおり
    • Organizer
      Audiology Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高齢者の聴覚と暮らし方と健康に関する学術調査(第2報)GWASによる老人性難聴関連遺伝子多型の探索2019

    • Author(s)
      野口 勝
    • Organizer
      Audiology Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] Phase characteristics of Otoacoustic Emissions Evoked by Amplitude-Modulated Low-Frequency Tone2019

    • Author(s)
      Toshimasa Ebina
    • Organizer
      ARO
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Enhancing wave-I of ABR by choosing the latency of rising-frequency chirp2018

    • Author(s)
      T morimoto, Y okamoto, Y hujisaka, T irino
    • Organizer
      ARO MidWinter Meeting 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 放射線照射が補聴器に与える影響2018

    • Author(s)
      岡本康秀
    • Organizer
      Audiology Japan
    • Related Report
      2018 Research-status Report
  • [Presentation] ワイドバンドティンパノメトリを用いた実耳挿入利得の予測2018

    • Author(s)
      泰地秀信、岡本康秀、神崎仁
    • Organizer
      Audiology Japan
    • Related Report
      2018 Research-status Report
  • [Presentation] Enhancing wave-I of ABR by choosing the latency of rising-frequency chirp2018

    • Author(s)
      Takasi Morimoto, Yasuhide Okamoto, Toshio Irino
    • Organizer
      ARO MidWinter Meeting 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 振幅変調音に対する聴性脳幹反応からの時間分解能閾値推定の検討2017

    • Author(s)
      森本隆司、岡本康秀
    • Organizer
      音響学会
    • Place of Presentation
      明治大学(東京都千代田区)
    • Year and Date
      2017-03-15
    • Related Report
      2016 Research-status Report
  • [Presentation] A auditory brainstem response to complex sounds with cochlear delay compensation2017

    • Author(s)
      Takashi Morimoto, Yasuhide Okamoto
    • Organizer
      Association for Research in Otolaryngology
    • Place of Presentation
      BALTIMORE(アメリカ)
    • Year and Date
      2017-02-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 「時間分解能測定の新しい試み」2017

    • Author(s)
      岡本康秀
    • Organizer
      日本聴覚医学会 第14回内耳ひずみ研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] Auditory Neuropathy(AN)と健聴者における複合音ABR(complex ABR:cABR)の相違2016

    • Author(s)
      岡本康秀、森本隆司
    • Organizer
      日本耳鼻咽喉科学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2016-05-18
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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