To study a mechanism of geographic atrophy in Japanese patients

• Project/Area Number: 16K11257
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hirosaki University (2019); Akita University (2016-2018)
• Principal Investigator: Saito Masaaki 弘前大学, 医学研究科, 講師 (90363754)
• Co-Investigator(Kenkyū-buntansha): 渡部 広史 秋田大学, 医学部, 研究員 (30595012) ; 西山 俊吾 秋田大学, 医学部附属病院, 医員 (10792806)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 加齢黄斑変性 / 萎縮型加齢黄斑変性 / ポリープ状脈絡膜血管症 / 光干渉断層系 / 網膜色素上皮 / 萎縮 / 網膜下出血 / 視力低下 / 地図状萎縮 / 眼科学

Outline of Final Research Achievements

We have reported about age-related macular degeneration (AMD) by annual meetings or journals. We also reported the clinical characteristics for geographic atrophy, that is to say retinal pigment epithelium (RPE) atrophy using fundus imagings. However, we should more duration to accumulate cases for analysis. A large, randomized, prospective study with longer follow-up is needed to confirm the current results.

Academic Significance and Societal Importance of the Research Achievements

萎縮型加齢黄斑変性の詳しい病態解明はまだ不明な要素が多い。そして有効な治療方法もまだない。現在本疾患は欧米で多いが、滲出型加齢黄斑変性の時のように日本でも今後増えることが強く予想される。そのため実際の症例ベースでの臨床所見の特徴や、長期の経過を見ていくこと、そこからの病態解明は今後の眼科学に役立つ可能性が高い。
またこれらの研究は今後のわが国での超高齢化社会における社会的失明患者の軽減に大いに役に立つと考えられる。

Research Products

• [Journal Article] Five-year follow-up of fundus autofluorescence and retinal sensitivity in the fellow eye in exudative age-related macular degeneration in Japan (2020)
  • Author(s): Shinojima Ari、Sawa Miki、Mori Ryusaburo、Sekiryu Tetsuju、Oshima Yuji、Kato Aki、Hara Chikako、Saito Masaaki、Sugano Yukinori、Ashikari Masayuki、Hirano Yoshio、et al.
  • Journal Title: PLOS ONE Volume: 15 Issue: 3 Pages: e0229694-e0229694
  • DOI: 10.1371/journal.pone.0229694
  • Peer Reviewed / Open Access
• [Journal Article] Fundus autofluorescence and retinal sensitivity in fellow eyes of age-related macular degeneration in Japan. (2019)
  • Author(s): Yasukawa T, Mori R, Sawa M, Shinojima A, Hara C, Sekiryu T, Oshima Y, Saito M, Sugano Y, Kato A, Ashikari M, Hirano Y, Asato H, Nakamura M, Matsuno K, Kuno N, Kimura E, Nishiyama T, Yuzawa M, Ishibashi T, Ogura Y, Iida T, Gomi F.
  • Journal Title: PLoS One Volume: 28
  • Peer Reviewed
• [Journal Article] Prognostic factors after aflibercept therapy for typical age-related macular degeneration and polypoidal choroidal vasculopathy. (2018)
  • Author(s): Ogasawara M, Koizumi H, Yamamoto A, Itagaki K, Saito M, Maruko I, Okada AA, Iida T, Sekiryu T.
  • Journal Title: Jpn J Ophthalmol Volume: 62 Pages: 584-591
  • Peer Reviewed
• [Journal Article] Efficacy of intravitreal aflibercept in Japanese patients with exudative age-related macular degeneration. (2017)
  • Author(s): Saito M, Kano M, Itagaki K, Sekiryu T.
  • Journal Title: Jpn J Ophthalmol Volume: 61 Issue: 1 Pages: 74-83
  • DOI: 10.1007/s10384-016-0478-5
  • NAID: 210000170190
  • Peer Reviewed
• [Journal Article] Subfoveal Choroidal Thickness in Polypoidal Choroidal Vasculopathy After Switching to Intravitreal Aflibercept Injection. (2016)
  • Author(s): Saito M, Iida T, Kano M, Itagaki K.
  • Journal Title: Jpn J Ophthalmol Volume: 60 Pages: 42-50
  • NAID: 210000170634
  • Peer Reviewed
• [Journal Article] Two-Year Results of Combined Intravitreal Ranibizumab and Photodynamic Therapy for Retinal Angiomatous Proliferation. (2016)
  • Author(s): Saito M, Iida T, Kano M, Itagaki K
  • Journal Title: Jpn J Ophthalmol Volume: 60 Pages: 42-50
  • NAID: 210000185382
  • Peer Reviewed
• [Journal Article] Subfoveal Choroidal Thickness during Aflibercept Therapy for Neovascular Age-Related Macular Degeneration: Twelve-Month Results. (2016)
  • Author(s): Koizumi H, Kano M, Yamamoto A, Saito M, Maruko I, Sekiryu T, Okada AA, Iida T.
  • Journal Title: Ophthalmology Volume: 123 Pages: 617-624
  • Peer Reviewed
• [Presentation] The relation of RPE atrophy and long-term visual outcomes in Japanese patients with RAP (2019)
  • Author(s): Saito M, Abe S, Nishiyama S, Yoshitomi T
  • Organizer: The 34th APAO (Asia-Pacific Academy of Ophthalmology Congress)
  • Int'l Joint Research
• [Presentation] Fundus Autofluorescence of Retinal Angiomatous Proliferation in Japanese Patients (2018)
  • Author(s): Saito M, Itagaki K, Abe S, Nishiyama S, Sekiryu T, Yoshitomi T
  • Organizer: 2.American Academy of Ophthalmology Annual Meeting
  • Int'l Joint Research
• [Presentation] The relation of RPE atrophy and long-term visual outcomes in Japanese patients with RAP (2017)
  • Author(s): Saito M
  • Organizer: The 32nd APAO (Asia-Pacific Academy of Ophthalmology Congress)
  • Int'l Joint Research
• [Presentation] 網膜血管腫状増殖の僚眼の状態と発症兆候の検討 (2017)
  • Author(s): 齋藤昌晃
  • Organizer: 第121回日本眼科学会総会
• [Presentation] 典型加齢黄斑変性のafliberceptへの治療変更後の24か月成績 (2017)
  • Author(s): 齋藤昌晃
  • Organizer: 第34回日本眼循環学会
• [Presentation] 網膜血管腫状増殖に対するranibizumab個別化治療の1年成績 (2017)
  • Author(s): 齋藤昌晃
  • Organizer: 第56回日本網膜硝子体学会総会
• [Presentation] 網膜血管腫状増殖における網膜色素上皮萎縮の治療への影響と発症因子の検討 (2016)
  • Author(s): 齋藤昌晃
  • Organizer: 第55回日本網膜硝子体学会総会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-02
• [Presentation] 網膜血管腫状増殖に対する抗VEGF薬併用PDTの長期治療成績 (2016)
  • Author(s): 齋藤昌晃
  • Organizer: 第70回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 2016-11-04
• [Presentation] 網膜血管腫状増殖に対する 抗VEGF 療法の治療成績 (2016)
  • Author(s): 齋藤昌晃
  • Organizer: 第120回日本眼科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-08