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Analytical epidemiological study for investigating risk factor of ophthalmic diseases including age-related macular degeneration, and glaucoma.

Research Project

Project/Area Number 16K11271
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Ophthalmology
Research InstitutionKeio University

Principal Investigator

YUKI Kenya  慶應義塾大学, 医学部(信濃町), 講師 (00365347)

Project Period (FY) 2016-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords疫学研究 / 眼科 / 住民対象 / 緑内障 / 黄斑変性 / 近視 / 角膜内皮 / 光干渉断層計 / 角膜内皮細胞数 / 眼圧 / 糖尿病 / 疫学調査 / 眼科疾患 / 加齢黄斑変性 / 糖尿病網膜症 / 縦断研究 / 眼科検診 / 疫学 / リスク要因
Outline of Final Research Achievements

This study is an ophthalmic epidemiological study conducted in Chikusei City, Ibaraki Prefecture. About 10,000 residents of Chikusei City participated in this study. In this study, the refractive index measurement, intraocular pressure measurement, corneal endothelial cell number measurement, anterior chamber depth and axial length measurement, retinal thickness measurement and ophthalmic disease screening using optical coherence tomography, and fundus photography. As a result, we have revelated that there is a significant increase in corneal endothelium malformation in myopia, high intraocular pressure in diabetic patients, high rate of association between epiretinal membrane and retinal nerve fiber bundle defect, and association between intraocular pressure and high myopia.

Academic Significance and Societal Importance of the Research Achievements

本研究では近視眼では角膜内皮形状不良が有意に多いこと、糖尿病患者では眼圧が高値であること、黄斑上膜と網膜神経線維束欠損が合併する率が高いこと、眼圧と近視が関連していることを明らかにした。本研究で眼科疾患がそれぞれ複雑に関与していることを住民ベースで証明できたと考えている。近視は日本が直面している、予防可能とわかりつつある大きな問題である。本研究は眼圧が上がることにより近視が進行する可能性、近視のリスクや近視に伴い生じるリスクを証明できたと考えている。

Report

(6 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2021 2020 2019

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results)

  • [Journal Article] Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study2021

    • Author(s)
      Naohiko Aketa, Miki Uchino, Motoko Kawashima, Yuichi Uchino, Kenya Yuki, Yoko Ozawa, Mariko Sasaki, Kazumasa Yamagishi, Norie Sawada, Shoichiro Tsugane, Hiroyasu Iso
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-85617-4

    • NAID

      120007132372

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationships of diabetes and hyperglycaemia with intraocular pressure in a Japanese population: the JPHC-NEXT Eye Study.2020

    • Author(s)
      Hanyuda A, Sawada N, Yuki K, Uchino M, Ozawa Y, Sasaki M, Yamagishi K, Iso H, Tsubota K, Tsugane S.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 5355-5355

    • DOI

      10.1038/s41598-020-62135-3

    • NAID

      120007144780

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study.2020

    • Author(s)
      Uchida A, Sasaki M, Motomura K, Yuki K, Kurihara T, Tomita Y, Ozawa Y, Yamagishi K, Kawasaki R, Hanyuda A, Sawada N, Tsubota K, Tsugane S, Iso H.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 779-779

    • DOI

      10.1038/s41598-019-57260-7

    • NAID

      120007133035

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High Myopia and Its Associated Factors in JPHC-NEXT Eye Study: A Cross-Sectional Observational Study.2019

    • Author(s)
      Mori K, Kurihara T, Uchino M, Torii H, Kawashima M, Sasaki M, Ozawa Y, Yamagishi K, Iso H, Sawada N, Tsugane S, Yuki K, Tsubota K.
    • Journal Title

      J Cli Med

      Volume: 8 Issue: 11 Pages: 1788-1788

    • DOI

      10.3390/jcm8111788

    • NAID

      120007133033

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2016-04-21   Modified: 2022-01-27  

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