Evaluation of atherosclerosis using novel ocular-microcirculation system.

• Project/Area Number: 16K11275
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Toho University
• Principal Investigator: SHIBA Tomoaki 東邦大学, 医学部, 准教授 (40408810)
• Co-Investigator(Kenkyū-buntansha): 高橋 真生 東邦大学, 医学部, 講師 (00408783) ; 松本 直 東邦大学, 医学部, 准教授 (60385888)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 眼循環 / 動脈硬化 / レーザースペックルフローグラフィー / 眼底血流波形解析 / 眼科学 / 眼底循環

Outline of Final Research Achievements

We successfully demonstraited a real-time evaluation system for systemic-ocular microcirculation using LSFG in white rabbits.We conducted the present study to evaluate the influences of age and gender differences on the pulse waveform in the optic nerve head using LSFG in numerous healthy subjects and results show that the pulse waveform parameter in the ONH shown by LSFG differs between the genders and undergoes chronological changes that are different in part from the chronological changes in blood pressure.

Academic Significance and Societal Importance of the Research Achievements

白色家兎を用いた眼循環ー全身循環同時測定系を確立した。これにより種々の薬剤の全身循環への詳細な検討や、全身血管病の眼循環への影響をリアルタイムで観察することが可能となった。
人間ドック研究での眼循環に対する性差、加齢の影響が解明されつつり、今後網膜血管病の病態解明において一助となる。

Research Products

• [Journal Article] Pulse Waveform Analysis in Ocular Microcirculation by Laser Speckle Flowgraphy in Patients with Left Ventricular Systolic and Diastolic Dysfunction (2018)
  • Author(s): Shiba Tomoaki、Takahashi Mao、Matsumoto Tadashi、Hori Yuichi
  • Journal Title: Journal of Vascular Research Volume: 55 Issue: 6 Pages: 329-337
  • DOI: 10.1159/000494066
  • Peer Reviewed
• [Journal Article] The relationships between the pulsatile flow form of ocular microcirculation by laser speckle flowgraphy and the left ventricular end-diastolic pressure and mass (2018)
  • Author(s): Shiba Tomoaki、Takahashi Mao、Shiba Chieko、Matsumoto Tadashi、Hori Yuichi
  • Journal Title: The International Journal of Cardiovascular Imaging Volume: 34 Issue: 11 Pages: 1715-1723
  • DOI: 10.1007/s10554-018-1388-z
  • Peer Reviewed
• [Journal Article] Relationship between Metabolic Syndrome and Ocular Microcirculation Shown by Laser Speckle Flowgraphy in a Hospital Setting Devoted to Sleep Apnea Syndrome Diagnostics (2017)
  • Author(s): Shiba Tomoaki、Takahashi Mao、Matsumoto Tadashi、Hori Yuichi
  • Journal Title: Journal of Diabetes Research Volume: 2017 Pages: 1-10
  • DOI: 10.1155/2017/3141678
  • Peer Reviewed / Open Access
• [Journal Article] Arterial stiffness shown by the cardio-ankle vascular index is an important contributor to optic nerve head microcirculation (2017)
  • Author(s): Shiba Tomoaki、Takahashi Mao、Matsumoto Tadashi、Shirai Kohji、Hori Yuichi
  • Journal Title: Graefe's Archive for Clinical and Experimental Ophthalmology Volume: 255 Issue: 1 Pages: 99-105
  • DOI: 10.1007/s00417-016-3521-9
  • Peer Reviewed / Open Access
• [Presentation] Pulse waveform analysis of ocular microcirculation can detect left ventricular diastolic and systolic dysfunction (2017)
  • Author(s): Tomoaki Shiba
  • Organizer: American Academy of Ophthalmology anuual meeting 2017
  • Int'l Joint Research