| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Alpha-B crystallin was subretinally injected in the eye of experimental retinal detachment. In the eyes of Brown-Norway rats, the maximum apoptosis of photoreceptors was observed at three days after the creation of retinal detachment. The percentages of TUNEL-positive apoptotic photoreceptors were 0.15 after the injection of 20 micrograms of alpha-B crystallin and 0.67 after the injection of 2 micrograms and 0.88 after 0.2 micrograms. In the rat eyes with experimental retinal detachment, the reduction of photoreceptor cell death by alpha-b crystallin was suggested.
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