Therapeutic approach against allergic conjunctivitis by oral immune tolerance
| Project/Area Number |
16K11324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kochi University |
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Principal Investigator |
FUKUSHIMA Atsuki 高知大学, 教育研究部医療学系臨床医学部門, 教授 (40281737)
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| Research Collaborator |
ISHIDA Waka
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アレルギー / 結膜炎 / 経口免疫寛容 / 制御性T細胞 / 好酸球 / T細胞 / アレルギー性結膜炎 / マウス / 卵白アルブミン / アレルギー・ぜんそく / 免疫学 |
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| Outline of Final Research Achievements |
To investigate the effects of oral tolerance on antigen-specific allergic conjunctivitis in mice, ovalbumin was used as the antigen. Oral administration of ovalbumin suppressed the development of allergic conjunctivitis (oral tolerance induction). We also revealed that the most effective method of oral administration was by using sonde. Furthermore, mechanistic analyses demonstrated that oral tolerance in our experimental situation does not depend on either suppression of antigen-specific immunoglobulin production or induction of regulatory T cells.
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| Academic Significance and Societal Importance of the Research Achievements |
我々はアレルギー性結膜炎の動物モデルにおいて、抗原感作前に経口免疫寛容を誘導することにより、結膜炎の発症を制御できることを報告してきた。しかし、我々の検討した系においても、感作成立後に経口免疫寛容を誘導した場合、結膜炎を制御することは難しい結果が得られてきた。抗原特異的経口免疫寛容を臨床の現場でアレルギー性結膜炎の治療に結びつけるためには、感作成立後、いかにして免疫寛容を誘導するべきかを検討する必要がある。本研究では、抗原感作成立後に経口免疫寛容を誘導するための手法を探索した。本研究成果は、臨床現場で経口免疫寛容により治療を検討する際の論理的礎となる。
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Japanese guidelines for allergic conjunctival diseases 20172017
Author(s)
Takamura E, Uchio E, Ebihara N, Ohno S, Ohashi Y, Okamoto S, Kumagai N, Satake Y, Shoji J, Nakagawa Y, Namba K, Fukagawa K, Fukushima A, Fujishima H,The Japanese Society of Allergology.
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Journal Title
Allergology International
Volume: 66
Issue: 2
Pages: 220-229
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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[Journal Article] Outbreak of immediate-type hydrolyzed wheat protein allergy due to a facial soap in Japan.2017
Author(s)
Yagami A, Aihara M, Ikezawa Z, Hide M, Kishikawa R, Morita E, Chinuki Y, Fukutomi Y, Urisu A, Fukushima A, Itagaki Y, Sugiura SI, Tanaka H, Teshima R, Kato Z, Noguchi E, Nakamura M, Saito H, Matsunaga K.
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Journal Title
J Allergy Clin Immunol.
Volume: 140
Issue: 3
Pages: 879-881
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Steroid-Sparing Effect of 0.1% Tacrolimus Eye Drop for Treatment of Shield Ulcer and Corneal Epitheliopathy in Refractory Allergic Ocular Diseases2017
Author(s)
Miyazaki D, Fukushima A, Ohashi Y, Ebihara N, Uchio E, Okamoto S, Shoji J, Takamura E, Nakagawa Y, Namba K, Fujishima H.
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Journal Title
Ophthalmology
Volume: 124
Issue: 3
Pages: 287-294
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Contributions of Intreleukin-33 and TSLP in a papain-soaked contact lens-induced mouse conjunctival Inflammation model.2017
Author(s)
Sugita J, Asada Y , Ishida W, Iwamoto S, Sudo K, Suto H, Matsunaga T, Fukuda K, Fukushima A, Yokoi N, Ohno T, Azuma M, Ebihara N, Saito H, Kubo M, Nakae S, Matsuda A.
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Journal Title
Immunity, Inflammation and Disease.
Volume: 5(4)
Issue: 4
Pages: 515-525
DOI
Related Report
Peer Reviewed / Open Access
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