| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
To investigate the effects of oral tolerance on antigen-specific allergic conjunctivitis in mice, ovalbumin was used as the antigen. Oral administration of ovalbumin suppressed the development of allergic conjunctivitis (oral tolerance induction). We also revealed that the most effective method of oral administration was by using sonde. Furthermore, mechanistic analyses demonstrated that oral tolerance in our experimental situation does not depend on either suppression of antigen-specific immunoglobulin production or induction of regulatory T cells.
|
