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Elucidation of mechanisms between endothelial injury and host immune response in severe trauma patients

Research Project

Project/Area Number 16K11401
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionOsaka University

Principal Investigator

OSUKA AKINORI  大阪大学, 医学系研究科, 招へい教員 (60552081)

Co-Investigator(Kenkyū-buntansha) 高橋 弘毅  関西医科大学, 医学部, 助教 (30609590)
嶋津 岳士  大阪大学, 医学系研究科, 教授 (50196474)
清水 健太郎  大阪大学, 医学部附属病院, 助教 (60379203)
小倉 裕司  大阪大学, 医学系研究科, 准教授 (70301265)
松浦 裕司  大阪大学, 医学部附属病院, 医員 (10791709)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords熱傷 / 血管内皮 / 腸管 / 多臓器不全 / サイトカイン / グリコカリックス / C1インヒビター / I-FABP / グルコカリクス / グリコカリクス / 血管内皮障害 / 免疫学 / 外傷 / 感染症 / 生体侵襲
Outline of Final Research Achievements

Severe burn injury damage not only injured site, but also endotherial cells and intestinal cells of the injured host. The endotherial damage increase fluid requirements to resuscitate the burn injury. And the intestinal damage is associated with development of multiple organ dysfunction syndrome. Many kinds of cytokines are released to respond the raumatic damage and work as immunological messangers. These cytokines networks each other. The network change with time following the injury. We can predict the patients prognosis by analyzing the network changes.

Academic Significance and Societal Importance of the Research Achievements

重症熱傷を受傷した後に大量の蘇生輸液が必要になるメカニズムの一部を解明した。多臓器不全に至る原因として腸管が大きな役割を担っていることも解明した。さらにサイトカインはネットワークとしてみることが重要であることも解明した。これらの知見により、今までに行われてきた治療を見直し、新たな治療戦略の開発が可能になり、今までは助からなかった不幸な事故の被害者を救命できるようになる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Clinical Importance of a Cytokine Network in Major Burns.2018

    • Author(s)
      Matsuura H, Matsumoto H, Osuka A, Ogura H, Shimizu K, Kang S, Tanaka T, Ueyama M, Shimazu T.
    • Journal Title

      Shock

      Volume: 印刷中 Issue: 2 Pages: 185-193

    • DOI

      10.1097/shk.0000000000001152

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Glycocalyx Shedding is Enhanced by Age and Correlates with Increased Fluid Requirement in Patients with Major Burns.2018

    • Author(s)
      Osuka A, Kusuki H, Yoneda K, Matsuura H, Matsumoto H, Ogura H, Ueyama M.
    • Journal Title

      Shock

      Volume: 印刷中 Issue: 1 Pages: 60-65

    • DOI

      10.1097/shk.0000000000001028

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腸管と腸内微小生態系の変化が重症病態に及ぼす役割2017

    • Author(s)
      大須賀 章倫, 米田 和弘, 工藤 大介, 清水 健太郎, 小倉 裕司
    • Journal Title

      日本救急医学会雑誌

      Volume: 28 Issue: 11 Pages: 827-834

    • DOI

      10.1002/jja2.12231

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute intestinal damage following severe burn correlates with the development of multiple organ dysfunction syndrome: A prospective cohort study2016

    • Author(s)
      Akinori Osuka, Hirofumi Kusuki, Hiroshi Matsuura, Kentaro Shimizu, Hiroshi Ogura, Masashi Ueyama
    • Journal Title

      Burns

      Volume: - Issue: 4 Pages: 824-829

    • DOI

      10.1016/j.burns.2016.10.015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] EARLY DROPS IN BLOOD CELLS ARE PROGNOSTIC MARKERS IN PATIENTS WITH MAJOR BURNS2018

    • Author(s)
      Akinori Osuka, Takuma Ishihara, Kentaro Shimizu, Ayumi Shintani, Hiroshi Ogura, Masashi Ueyama
    • Organizer
      Society of Critical Care Medicine’s 47th Critical Care Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Acute intestinal damage following severe burn injury correlates with the development of multiple organ dysfunction syndrome2017

    • Author(s)
      Akinori Osuka, Hirofumi Kusuki, Kazuhiro Yoneda, Kentaro Shimizu, Hiroshi Ogura
    • Organizer
      第44回 日本集中治療学会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2017-03-08
    • Related Report
      2016 Research-status Report
  • [Presentation] THE KEY CYTOKINE NETWORK ASSOCIATED WITH THE SEVERITY AND PROGNOSIS IN EXTENSIVE BURN PATIENTS2017

    • Author(s)
      Hiroshi Matsuura, Hisatake Matsumoto, Akinori Osuka, Hiroshi Ogura, Toshihiro Tanaka, Suijin Kang, Takeshi Shimazu
    • Organizer
      46TH CRITICAL CARE CONGRESS
    • Place of Presentation
      HONOLULU, HAWAII, USA
    • Year and Date
      2017-01-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Acute intestinal damage following burn injury correlates with the development of MODS2017

    • Author(s)
      Akinori Osuka, Hirofumi Kusuki, Kazuhiro Yoneda, Kentaro Shimizu, Hiroshi Ogura
    • Organizer
      The 17th Joint Scientific Congress of the KCCM and JSICM
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] AGING IS A CRUCIAL FACTOR FOR GLYCOCALYX DISRUPTION LEADING TO INCREASE RESUSCITATION FLUID REQUIREMENT IN BURN PATIENTS2017

    • Author(s)
      Akinori Osuka, Hiroshi Matsuura, Hiroshi Ogura
    • Organizer
      76th Annual Meeting of AAST and Clinical Congress of Acute Care Surgery
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 広範囲熱傷におけるグリコカリクスの崩壊2016

    • Author(s)
      大須賀章倫、松本寿健、松浦裕司、黒木雄一、宮尾大樹、米田和弘、中島紳史、高橋弘毅、清水健太郎、小倉裕司、上山昌史
    • Organizer
      第44回 日本救急医学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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