| Project/Area Number |
16K11409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
KANEKO TADASHI 熊本大学, 医学部附属病院, 講師 (50362372)
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| Co-Investigator(Kenkyū-buntansha) |
高橋 毅 独立行政法人国立病院機構熊本医療センター(臨床研究部), 独立行政法人国立病院機構熊本医療センター(臨床研究部), 副院長 (20516140)
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| Research Collaborator |
Harada Masahiro
Sakurai Toshihiro
Kitada Maki
Yamada Shu
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 頭部外傷 / バイオマーカー / 診断 / 頭部CT / ＧＣＳ / ＧＦＡＰ / グリア / 神経膠細胞 |
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| Outline of Final Research Achievements |
Serum glial fibrillary acidic protein is one of the biomarker of brain injury. Serum GFAP showed well correlation to traumatic brain injury findings in head computed tomography, compare to other biomarkers (pNF-H, H-FABP, NSE, S100B). Therefore, serum GFAP could support the dinagnosis of traumatic brain injury, and could be new diagnostic biomarker in clinical setting.
In future, serum GFAP could be used as clinical diagnostic biomarker in emergency situation and/or medical examination.
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| Academic Significance and Societal Importance of the Research Achievements |
頭部外傷の診断は，頭部CTの開発とともに格段の進歩を遂げたものの，依然見落とし・誤診などの問題が無くなっていない．診察・頭部CT以外に有用な診断方法の開発が検討されるべき領域であるが，今回，血液検査である血清GFAP測定の有用性が示唆された．
臨床現場での頭部外傷診断の補助に利用可能と考えられ，同病態の成績向上に寄与するものと考えられる．
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